Results 51 to 60 of about 206,101 (297)

New Trends in Synthetic Medicinal Chemistry. (Methods and Principles in Medicinal Chemistry, Volume 7)

Molecules, 2001
n ...
Fulvio Gualtieri
doaj   +1 more source

Women in Medicinal Chemistry Special Issue Call for Papers

, 2019
The Journal of Medicinal Chemistry will be publishing a special issue on “Women in Medicinal Chemistry” in March 2020 together with ACS Medicinal Chemistry Letters, publishing on the same topic.Full ...
Hong Liu, Ganamet, Kelly L, Wang, Shaomeng, Shaomeng Wang, Bolognesi, Maria Laura, Gunda I. Georg, Maria Laura Bolognesi, Sally-Ann Poulsen, Georg, Gunda I, Liu, Hong, Poulsen, Sally-Ann, Kelly L. Ganamet   +11 more
core   +1 more source

Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry [PDF]

, 2022
Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality.
Eun Jung Oh, Chung, Ho Yun, Rajendran, Gayathri,; Bhanu, Deepu,; Aruchamy, Baladhandapani,; Ramani, Prasanna,; Pandurangan, Nanjan,; Bobba, Kondapa Naidu,; Oh, Eun Jung,; Chung, Ho Yun,; Gangadaran, Prakash,; Ahn, Byeong-Cheol,, Bhanu, Deepu, Ahn, Byeong-Cheol, Deepu Bhanu, Nanjan Pandurangan, Ho Yun Chung, Aruchamy, Baladhandapani, Baladhandapani Aruchamy, Prakash Gangadaran, Ramani, Prasanna, Gayathri Rajendran, Kondapa Naidu Bobba, Pandurangan, Nanjan, Byeong-Cheol Ahn, Rajendran, Gayathri, Bobba, Kondapa Naidu, Prasanna Ramani, Gangadaran, Prakash, Oh, Eun Jung   +20 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

Molecules, 2019
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]
Arduino A. Mangoni, Jean Jacques Vanden Eynde, Josef Jampilek, Dimitra Hadjipavlou-Litina, Hong Liu, Jóhannes Reynisson, Maria Emília Sousa, Paula A. C. Gomes, Katalin Prokai-Tatrai, Tiziano Tuccinardi, Jean-Marc Sabatier, F. Javier Luque, Jarkko Rautio, Rafik Karaman, M. Helena Vasconcelos, Sandra Gemma, Stefania Galdiero, Christopher Hulme, Simona Collina, Michael Gütschow, George Kokotos, Carlo Siciliano, Raffaele Capasso, Luigi A. Agrofoglio, Rino Ragno, Diego Muñoz-Torrero   +25 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Assessing the impact of clinically relevant medicinal chemistry teaching: Learning gains from case study approach [PDF]

Brazilian Journal of Pharmaceutical Sciences
Considering the unique role of medicinal chemistry in the pharmacists’ formation, in this work we assessed the impact of medicinal chemistry teaching on the interpretation of a clinical situation using statistical and learning gain analysis.
Fernanda Domingues Lustoza, João Paulo S. Fernandes   +1 more
doaj   +1 more source

Medicinal chemistry teaching and training: a continuous adaptation

, 2009
Bridging the gap: The differences between medicinal chemistry at the industrial and academic levels raises the question: Is there a significant gap between the two spheres that requires attention, or should such differences be deemed natural, without the
Souza, N.J. de, Timmerman, H., Henk Timmerman, de Souza, N.J., Noel J. de Souza   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source