Stereochemical aspects of the nucleophilic attack in different classes of l-asparaginases [PDF]
IUCrJL-Asparaginases hydrolyze L-asparagine to L-aspartate with the release of ammonia. Currently, three completely unrelated structural classes of L-asparaginases are known, further subdivided into five types.
Miroslaw Gilski +2 more
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Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones
Molecules, 2023 The stereochemical properties of N-acyl-5H-dibenzo[b,d]azepin-7(6H)-ones (2a–c), which inhibit potassium channels in T cells, were examined by freezing their conformational change due to 4-methyl substitution.
Arisa Chiba +8 more
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Chemistry, Cyclophosphamide, Cancer Chemotherapy, and Serendipity: Sixty Years On
Substantia, 2021 Cambridge Dictionary: serendipity | noun | the phenomenon of finding interesting or valuable things by chance. The year 2019 marked the 60th anniversary of the approval of cyclophosphamide (CP) as an anticancer by the U.S.
Gerald Zon
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Fast and Accurate Prediction of Refractive Index of Organic Liquids with Graph Machines
Molecules, 2023 The refractive index (RI) of liquids is a key physical property of molecular compounds and materials. In addition to its ubiquitous role in physics, it is also exploited to impart specific optical properties (transparency, opacity, and gloss) to ...
François Duprat +3 more
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Synthesis of New C-3 Substituted Kynurenic Acid Derivatives
Molecules, 2020 The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi +3 more
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Synthesis and Conformational Analysis of Naphthoxazine-Fused Phenanthrene Derivatives
Molecules, 2020 The synthesis of new phenanthr[9,10-e][1,3]oxazines was achieved by the direct coupling of 9-phenanthrol with cyclic imines in the modified aza-Friedel–Crafts reaction followed by the ring closure of the resulting bifunctional aminophenanthrols with ...
Khadija Belasri +6 more
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Solvent-Free C-3 Coupling of Azaindoles with Cyclic Imines
Molecules, 2019 By direct coupling 7-azaindole and cyclic imines, such as 3,4-dihydroisoquinoline, 6,7-dihydrothieno[3,2-c]pyridine, 3,4-dihydro-β-carboline, and 4,5-dihydro-3H-benz[c]azepine, new 3-substituted 7-azaindole derivatives have been synthesized.
Khadija Belasri +2 more
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Synthesis of cyclopropanes via organoiron methodology: stereoselective preparation of cis-2-(2’-carboxycyclopropyl)glycine [PDF]
, 2002 A stereoselective route to cis-2-(2′-carboxycyclopropyl)glycine has been developed. exo-Nucleophilic addition to the (bicyclo[5.1.0]octadienyl)iron(1+) cation establishes the relative stereochemistry at the cyclopropane ring and the α-stereocenter ...
Donaldson, William, Wallock, Nathaniel J
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Femtosecond dynamics of hydrogen elimination: benzene formation from cyclohexadiene [PDF]
, 2000 Using femtosecond-resolved mass spectrometry in a molecular beam, we report real-time study of the hydrogen elimination reaction of 1,4-cyclohexadiene. The experimental observation of the ultrafast stepwise H-elimination elucidates the reaction dynamics ...
De Feyter, Steven +2 more
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Molecules, 2023 Chiral 2-substituted chromanes are important substructures in organic synthesis and appear in numerous natural products. Herein, the correlation between specific optical rotations (SORs) and the stereochemistry at C2 of chiral 2-substituted chromanes was
Bei-Bei Yang +5 more
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