Results 41 to 50 of about 118,878 (273)
The Metallacyclopentane-Olefin Interchange Reaction [PDF]
, 1977 Tris(triphenylphosphine)tetramethylenenickel(II) and biscyclopentadienyltetramethylenetitanium, prepared from the reaction of a 1,4-dilithiobutane and the transition metal dihalides react with olefins to produce substituted metallacyclopentanes; the ...
Grubbs, Robert H., Miyashita, Akira
core +1 more source
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin
Angewandte Chemie, EarlyView.We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu +3 more
wiley +2 more sources
Molecules, 2021 PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack of information regarding the optical purity (enantiomeric excess) of the single stereogenic centre of PF74 has resulted
Stuart Ruddell +5 more
doaj +1 more source
Advanced Science, EarlyView.A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du +18 more
wiley +1 more source
Angewandte Chemie, EarlyView.Cyclic diaryliodonium salts engage aryl Grignard reagents to trigger a self‐propagating aryne–arylation cycle. Transient cyclic triaryliodanes serve as aryne precursors and dynamic aryl reservoirs, delivering iodine‐capped teraryls with predominant meta‐selectivity. The preserved C─I bond enables outward π‐extension or inward recyclization.
Daichi Ikeshita +2 more
wiley +2 more sources
Molecules, 2019 Phyllanthus orbicularis (Phyllanthaceae) is an endemic evergreen tropical plant of Cuba that grows in the western part of the island and is used in traditional medicine as an infusion.
Antonio Francioso +8 more
doaj +1 more source
On biological homochirality [PDF]
, 2009 Generalizing Landau's spontaneous symmetry breaking arguments using the standard groupoid approach to stereochemistry allows reconsideration of the origin of biological homochirality.
Rodrick Wallace
core +1 more source
Stereochemistry of malkanguniol and stereostructures of some other related polyalcohols from celastrus paniculatus willd [PDF]
, 1974 This article does not have an ...
Hertog, H.J. den +3 more
core +2 more sources
Advanced Science, EarlyView.ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter +10 more
wiley +1 more source