Results 61 to 70 of about 63,316 (301)

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

open access: yesAdvanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang   +19 more
wiley   +1 more source

A Circular and Tacticity‐Independent Crystalline Mono‐Substituted Nylon‐6 Platform: Unexpected Large Positional Effects on Crystallizability and Performance

open access: yesAngewandte Chemie, EarlyView.
Methyl substitution positions on the nylon‐6 backbone markedly affect crystallizability, thermomechanical properties, and recyclability of the resulting atactic nylon‐6 variants. While γ‐methyl substitution gives an amorphous nylon, all other four methyl‐substitution positions (α, β, δ, and ε) afford, unexpectedly, crystalline nylons, showing tacticity‐
Jun‐Jie Tian   +9 more
wiley   +2 more sources

Bridging Performance and Fate: A Framework for Sustainable, Composite‐Based Flexible Electronic Systems

open access: yesAdvanced Electronic Materials, EarlyView.
Composite‐based flexible electronics integrate biodegradable polymers, conductive networks, and multilayer device architectures to balance electrical performance, mechanical durability, and controlled degradation. Interfacial engineering and encapsulation regulate transport stability and operational lifetime, while programmed disassembly enables ...
Sayam, Sangho Cho
wiley   +1 more source

Stereochemical outcomes of C–F activation reactions of benzyl fluoride

open access: yesBeilstein Journal of Organic Chemistry, 2018
In recent years, the highly polar C–F bond has been utilised in activation chemistry despite its low reactivity to traditional nucleophiles, when compared to other C–X halogen bonds.
Neil S. Keddie   +4 more
doaj   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng   +4 more
wiley   +1 more source

Stereochemistry of Astaxanthin Biosynthesis in the Marine Harpacticoid Copepod Tigriopus Californicus

open access: yesMarine Drugs, 2020
The harpacticoid copepod Tigriopus californicus has been recognized as a model organism for the study of marine pollutants. Furthermore, the nutritional profile of this copepod is of interest to the aquafeed industry.
Alfonso Prado-Cabrero   +2 more
doaj   +1 more source

Crystal structure of 9-methacryloylanthracene

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C18H14O, with systematic name 1-(anthracen-9-yl)-2-methylprop-2-en-1-one, the ketonic C atom lies 0.2030 (16) Å out of the anthryl-ring-system plane. The dihedral angle between the planes of the anthryl and methacryloyl moieties is
Aditya Agrahari   +4 more
doaj   +1 more source

Stereochemistry of the Wittig reaction

open access: yes, 2007
A review, with 91 refs., of stereoselectivity in reactions of stable and reactive ylids, and the application of stereoselective carbonyl olefinations. [on SciFinder (R)]LSCOCAN 74:3127622Physical Organic ChemistryOrg.-Chem. Inst.,Univ.
Manfred Schlosser, Schlosser, Manfred
core   +1 more source

Five-membered ring annelation in [2.2]paracyclophanes by aldol condensation

open access: yesBeilstein Journal of Organic Chemistry, 2014
Under basic conditions 4,5,12,13-tetraacetyl[2.2]paracyclophane (9) cyclizes by a double aldol condensation to provide the two aldols 12 and 15 in a 3:7 ratio.
Henning Hopf   +2 more
doaj   +1 more source

Contribution of the Chemistry Institutes to the Early Development of Stereochemistry

open access: yesCHIMIA, 2009
This article is a translation from German of a paper submitted by Kurt Hermann to the University of Zurich Prize committee in 1968, with additional editing by Jay Siegel.
Kurt Hermann
doaj   +1 more source

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