Results 71 to 80 of about 40,087 (250)
Angewandte Chemie, EarlyView.A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster +13 more
wiley +2 more sources
Angewandte Chemie, EarlyView.π‐Extended COUPY dyes, obtained by vinylogation of coumarin‐based COUPY scaffolds, shift absorption, and emission deep into the NIR region while preserving compactness and synthetic accessibility. These bright, photostable dyes enable live‐cell imaging, FLIM, and site‐specific peptide conjugation, offering a modular platform for targeted bioimaging and
Diego Abad‐Montero +11 more
wiley +2 more sources
DESIGN OF AN EDUCATIONAL GAME AND ITS USE IN A TEAM GAME TOURNAMENT AS A STRATEGY TO ENGAGE STUDENTS IN REVIEWING STEREOCHEMISTRY CONCEPTS [PDF]
Química NovaThis paper presents a Chemistry Team Game Tournament (TGT) as a didactic strategy to review stereochemistry concepts. For this purpose, a multilingual (English, Italian, French, and Portuguese) educational game, Stereochemistry Race, was developed on the
José Nunes da Silva Júnior +8 more
doaj +1 more source
Ortho‐Quinone Methide Driven Synthesis of New O,N‐ or N,N‐Heterocycles
ChemistryOpen, 2019 To synthesize functionalized Mannich bases that can serve two different types of ortho‐quinone methide (o‐QM) intermediates, 2‐naphthol and 6‐hydroxyquinoline were reacted with salicylic aldehyde in the presence of morpholine.
Dr. István Szatmári +5 more
doaj +1 more source
Natural Product Communications, 2019 Highly oxygenated nortriterpenoids are the principle bioactive chemical constituents isolated from plants of the genera Schisandra and Kadsura . The stereochemistry of these molecules remains a highly challenging problem to solve.
Xiaojuan Wang, Mark T. Hamann
doaj +1 more source
Stereochemical Research on Cembranes Diterpenoid Sinulariol Z Based on Residual Dipolar Couplings
Chinese Journal of Magnetic ResonanceResearch on the stereochemistry of natural products, especially that of flexible macrocyclic molecules, has always been a huge challenge. Cembranes diterpenoids are a typical class of flexible macrocyclic molecules, whose configurations are often ...
SHI Xing +3 more
doaj +1 more source
Polarimetry and stereochemistry: the optical rotation of Vitamin C as a function of pH
Educación Química, 2015 A novel experiment was prepared to help chemistry educators to improve the stereochemistry curriculumof secondary school students and undergraduate students.
Johan A. Linthorst +1 more
doaj +1 more source
Journal of Lipid Research, 2001 We identified a new peroxisomal disorder caused by a deficiency of the enzyme α-methylacyl-coenzyme A (CoA) racemase. Patients with this disorder show elevated plasma levels of pristanic acid and the bile acid intermediates di- and trihydroxycholestanoic
Sacha Ferdinandusse +5 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.The first catalytic asymmetric formal [3+2] cycloaddition of allylsilanes delivers cis‐2,5‐disubstituted tetrahydrofuran‐3‐ones that serve as versatile intermediates for the synthesis of diverse bioactive scaffolds. ABSTRACT A formal [3+2] cycloaddition via cyclization/1,2‐hydride shift initiated by nucleophilic attack of allylsilanes has been ...
Hosung Lee +5 more
wiley +1 more source