Results 91 to 100 of about 40,087 (250)

Revisiting Securidaca longipedunculata Seed Oil: Applying NMR and Mass Spectroscopy to Confirm the Presence of 2‐Acetyl‐1,3‐Diacyl–sn‐Glycerols and Conjugated Hydroxydienoic Fatty Acids

Journal of the American Oil Chemists' Society, EarlyView.
The manuscript confirms and expands on previous reports concerning the presence of unusual conjugated hydroxydienoic fatty acids and acetyl‐TAG in the seed oil of Securidaca longipedunculata. The location of acetate only at sn‐2 of TAG was conclusively shown by high resolution NMR and hydroxy seed fatty acids are characterized.
Mark A. Smith, Jianfeng Zhu, Jin‐Yue Sun   +2 more
wiley   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Stereoselective Higher‐Order [10+4]‐ and [10+6] Cycloadditions Between Two Highly Unsaturated and Ambiphilic π‐Addends

Chemistry – A European Journal, EarlyView.
Aminocatalytically generated isobenzofulvenes and 3‐oxidopyridinium betaines act as ambiphilic reaction partners in orbital‐symmetry‐allowed [10+4] cycloadditions or formally symmetry‐forbidden concerted thermal [10+6] cycloadditions. The reaction furnishes three cycloadducts: one [10+4] cycloadduct and two regioisomeric [10+6] cycloadducts.
Jonas Faghtmann, Anne Kristensen, Fabien Fritz, Signe Sofie Pladsbjerg Andresen, Anne Rask Østergaard, Johannes Nygaard Lamhauge, K. N. Houk, Karl Anker Jørgensen   +7 more
wiley   +1 more source

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, EarlyView.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source

The Palladium(IV)‐Centered Hexatungstate Ion [PdIVW6O24]8−

Chemistry – A European Journal, EarlyView.
The first structurally characterized palladium(IV)‐containing polyoxotungstate was prepared, [PdIVW6O24]8− (PdW6), comprising a central 6‐coordinated PdIV ion surrounded by a ring of six edge‐shared WO6 octahedra. The redox chemistry of PdIV in PdW6 was investigated by electrochemistry.
Pooja Kulashri, Xiang Ma, Mahmoud Elcheikh Mahmoud, Bassem S. Bassil, Talha Nisar, Veit Wagner, Samer Dawoud, Laurent Ruhlmann, Ulrich Kortz   +8 more
wiley   +1 more source

Synthesis and Structure of an S‐Shaped Double Expanded Helicene With Seven Fused Anthracene Units

Chemistry – A European Journal, EarlyView.
The anthracene‐fused aromatic compound was synthesized by four‐fold cycloisomerization of the corresponding alkyne precursor. X‐ray crystallographic analysis revealed that this compound had a double helical structure of Ci symmetry, in which the terminal and central anthracene units were triply stacked.
Shinji Toyota, Kaito Hohno, Takehiro Kihara, Yu Watanabe, Yuki Shigihara, Eiji Tsurumaki, Masahiro Yamashina   +6 more
wiley   +1 more source

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics

Chemistry – A European Journal, EarlyView.
A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova, Jan L. Venne, Sona Krajcovicova, James Dodgson, Wouter F. J. Hogendorf, Thomas E. Nielsen, David Hymel, Hannah Bolt, Andie Collinson, Jason Day, Jefferson Revell, David R. Spring   +11 more
wiley   +1 more source

Exploring Calixarene‐Based Pseudorotaxane Architectures: Threading Ammonium Axles With an Exo‐Rim π‐Functionalized Calix[6]Arene Macrocycle

Chemistry – A European Journal, EarlyView.
This research presents a novel 1,4‐π‐functionalized calix[6]arene with enhanced interactions with dialkylammonium axles. We investigate threading behavior in CDCl3, highlighting how exo‐rim π‐functionalization affects binding affinity and stereoselectivity.
Veronica Iuliano, Paolo Della Sala, Placido Neri, Donato De Simone, Rocco Del Regno, Margherita De Rosa, Carmine Gaeta, Carmen Talotta   +7 more
wiley   +1 more source