Results 21 to 30 of about 118,878 (273)

Advancing peptide siRNA-carrier designs through L/D-amino acid stereochemical modifications to enhance gene silencing

Molecular Therapy: Nucleic Acids, 2021
The 599 peptide has been previously shown to effectively deliver small interfering RNAs (siRNAs) to cancer cells, inducing targeted-oncogene silencing, with a consequent inhibition of tumor growth. Although effective, this study was undertaken to advance
Charles E. Holjencin, Colton R. Feinberg, Travis Hedrick, Gregory Halsey, Robert D. Williams, Priya V. Patel, Evan Biles, James C. Cummings, Chance Wagner, Naren Vyavahare, Andrew Jakymiw   +10 more
doaj   +1 more source

Asymmetric Synthesis of 1-Heteroaryl-1-arylalkyl Tertiary Alcohols and 1-Pyridyl-1-arylethanes by Lithiation-Borylation Methodology [PDF]

, 2013
The synthesis of highly enantioenriched alpha-heterocyclic tertiary alcohols has been achieved via lithiation-borylation of a configurationally stable lithiated carbamate and heterocyclic pinacol boronic esters followed by oxidation. Protodeboronation of
Aggarwal V. K., Biradar D. B., Biradar D. B., Carstens A., Charlotte G. Watson, Chen C.-A., Cozzi P. G., Dosa P. I., García C., García C., García C., Garg D. C., Greene M. A., Hatano M., Hatano M., Hatano M., Hoppe D., Hu Q., Kanai M., Luderer M. R., Madduri A. V. R., Madduri A. V. R., Maity P., Matsunaga N., Messaoudi S., Moree W. J., Nave S., Ou L., Pathak T. P., Ramón D. J., Ramón D. J., Shi S.-L, Shibasaki M., Song S., Starck J. P., Stymiest J. L., Taylor B. L. H., Varinder K. Aggarwal, Wada R., Weber B., Yus M., Yus M.   +41 more
core   +3 more sources

[1,3]/[1,4]-Sulfur atom migration in β-hydroxyalkylphosphine sulfides

Beilstein Journal of Organic Chemistry, 2020
β-Hydroxyalkylphosphine sulfides undergo [1,3]- or [1,4]-sulfur atom phosphorus-to-carbon migration in the presence of Lewis or Brønsted acids. The direction of sulfur atom migration depends on the type of acid used for the reaction. In the presence of a
Katarzyna Włodarczyk, Piotr Borowski, Marek Stankevič   +2 more
doaj   +1 more source

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]

, 2015
MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng, Chu, Aurea, David, Sheila S, Horvath, Martin P, O'Shea, Valerie L, Richards, Jody L, Woods, Ryan D   +6 more
core   +2 more sources

A Comparative Study on Interactions of Antimicrobial Peptides L- and D-phenylseptin with 1,2-dimyristoyl-sn-glycero-3-phosphocholine

Applied Sciences, 2019
L-phenylseptin (L-Phes) and D-phenylseptin (D-Phes) are amphibian antimicrobial peptides isolated from the skin secretion of Hypsiboas punctatus. In the N-termini, L-Phes and D-Phes contain three consecutive phenylalanine residues, l-Phe-l-Phe-l-Phe and ...
Batsaikhan Mijiddorj, Yuta Matsuo, Hisako Sato, Kazuyoshi Ueda, Izuru Kawamura   +4 more
doaj   +1 more source

Ortho‐Quinone Methide Driven Synthesis of New O,N‐ or N,N‐Heterocycles

ChemistryOpen, 2019
To synthesize functionalized Mannich bases that can serve two different types of ortho‐quinone methide (o‐QM) intermediates, 2‐naphthol and 6‐hydroxyquinoline were reacted with salicylic aldehyde in the presence of morpholine.
Dr. István Szatmári, Khadija Belasri, Dr. Matthias Heydenreich, Dr. Andreas Koch, Prof. Dr. Erich Kleinpeter, Prof. Dr. Ferenc Fülöp   +5 more
doaj   +1 more source

Organotin(IV) Dithiocarbamate Complexes: Chemistry and Biological Activity

Molecules, 2018
Significant attention has been given to organotin(IV) dithiocabamate compounds in recent times. This is due to their ability to stabilize specific stereochemistry in their complexes, and their diverse application in agriculture, biology, catalysis and as
Jerry O. Adeyemi, Damian C. Onwudiwe
doaj   +1 more source

Mechanism-based Enzyme Inactivators of Phytosterol Biosynthesis

Molecules, 2004
Current progress on the mechanism and substrate recognition by sterol methyl transferase (SMT), the role of mechanism-based inactivators, other inhibitors of SMT action to probe catalysis and phytosterol synthesis is reported.
W. David Nes, Mathew B. Miller, Phani Veeramachanemi, Archana Sinha, Pruthvi Jayasimha, Jialin Liu, Ragu Kanagasabai, Zhihong Song, Wenxu Zhou   +8 more
doaj   +1 more source

How and How Much Molecular Conformation Affects Electronic Circular Dichroism: The Case of 1,1-Diarylcarbinols

Molecules, 2018
Chiroptical spectra such as electronic circular dichroism (ECD) are said to be much more sensitive to conformation than their non-chiroptical counterparts, however, it is difficult to demonstrate such a common notion in a clear-cut way.
Daniele Padula, Gennaro Pescitelli
doaj   +1 more source

Chiroptical studies on brevianamide B : vibrational and electronic circular dichroism confronted [PDF]

, 2015
Chiroptical spectroscopy, such as electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) are highly sensitive techniques to probe molecular conformation, configuration, solvation and aggregation.
Bultinck, Patrick, Cherblanc, Fanny L, Fuchter, Matthew J, Herrebout, Wouter A, Lo, Ya-Pei, Rzepa, Henry S, Siligardi, Giuliano, Weimar, Marko   +7 more
core   +2 more sources