Results 1 to 10 of about 14,677 (287)

4,5-Dihydro-2H-pyridazin-3-ones as a Platform for the Construction of Chiral 4,4-Disubstituted-dihydropyridazin-3-ones [PDF]

Molecules
4,5-Dihydro-2H-pyridazin-3-ones (DHPDOs) are important synthetic as well as naturally occurring heterocycles. We herein report the synthesis of various 4-monofunctionalized 4,5-dihydro-2H-pyridazin-3-ones and their use as starting materials to access 4,4-
Paul Joël Henry, Gabriel Burel, William Nzegge, Mario Waser, Jean-François Brière   +4 more
doaj   +2 more sources

Site- and enantioselective B−H functionalization of carboranes [PDF]

Nature Communications
Functionalization of carboranes, icosahedral boron−carbon molecular clusters, is of great interest as they have wide applications in medicinal and materials chemistry.
Kyungsup Lee, Gisela A. González-Montiel, Hyeonsik Eom, Tae Hyeon Kim, Hee Chan Noh, Abdikani Omar Farah, Henry R. Wise, Dongwook Kim, Paul Ha-Yeon Cheong, Phil Ho Lee   +9 more
doaj   +2 more sources

Stereospecific Construction of Quaternary Carbon Stereocenters from Quaternary Carbon Stereocenters

Journal of the American Chemical Society, 2022
Organoaluminum species promote a smooth nucleophilic substitution at the quaternary carbon stereocenter of stereodefined polysubstituted cyclopropyl methyl phosphate with a complete inversion of configuration, even when more reactive functional groups are present. The regio- and diastereoselectivity of the substitution is attributed to the existence of
Patel, Kaushalendra, Lanke, Veeranjaneyulu, Marek, Ilan   +2 more
openaire   +2 more sources

Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand

Nature Communications, 2021
Installation of difluoroalkyl groups while also imparting stereochemical information is mostly only possible with organocatalytic methods that activate carbonyls.
Shuai Huang, Fei-Fei Tong, Da-Chang Bai, Gao-Peng Zhang, Yang-Jie Jiang, Bo Zhang, Xuebing Leng, Ying-Long Guo, Xiao-Long Wan, Xingang Zhang, Chang-Hua Ding, Xue-Long Hou   +11 more
doaj   +1 more source

A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation

Nature Communications, 2021
Enantiomeric bridged [2,2,1] bicyclic lactone skeletons and their ring-opening products are important scaffolds widely occurring in both pharmaceutics and biology active compounds.
Shuailong Li, Zhuangxing Li, Mingzheng Li, Lin He, Xumu Zhang, Hui Lv   +5 more
doaj   +1 more source

Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins

Nature Communications, 2021
Prenylated indole alkaloids contain spirooxindole rings with a 3R or 3S carbon stereocenter, which determines their bioactivities, but the biocatalytic mechanism controlling the 3R- or 3S-spirooxindole formation was unclear.
Zhiwen Liu, Fanglong Zhao, Boyang Zhao, Jie Yang, Joseph Ferrara, Banumathi Sankaran, B. V. Venkataram Prasad, Biki Bapi Kundu, George N. Phillips, Yang Gao, Liya Hu, Tong Zhu, Xue Gao   +12 more
doaj   +1 more source

Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process

Molecules, 2020
An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established.
Chenkai Meng, Haolin Niu, Juehan Ning, Wengang Wu, Jun Yi   +4 more
doaj   +1 more source

The Design, Synthesis, and Evaluation of Diaminopimelic Acid Derivatives as Potential dapF Inhibitors Preventing Lysine Biosynthesis for Antibacterial Activity

Antibiotics, 2022
We created thiazole and oxazole analogues of diaminopimelic acid (DAP) by replacing its carboxyl groups and substituting sulphur for the central carbon atom.
Mohd Sayeed Shaikh, Mayura A. Kale, V. Muralidharan, T. Venkatachalam, Syed Sarfaraz Ali, Fahadul Islam, Sharuk L. Khan, Falak A. Siddiqui, Humaira Urmee, Ganesh G. Tapadiya, Sachin A. Dhawale, Long Chiau Ming, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Md. Moklesur Rahman Sarker, Mohd Fahami Nur Azlina   +15 more
doaj   +1 more source

Asymmetric Construction of All-Carbon Quaternary Stereocenters by Chiral-Auxiliary-Mediated Claisen Rearrangement and Total Synthesis of (+)-Bakuchiol

Molecules, 2012
An asymmetric Claisen rearrangement using Oppolzer’s camphorsultam was developed. Under thermal conditions, a geraniol-derived substrate underwent the rearrangement with good stereoselectivity. The absolute configuration of the newly formed all-
Kin-ichi Tadano, Yusuke Kusakawa, Marianne Ayaka Touati, Shu Sakamoto, Ken-ichi Takao   +4 more
doaj   +1 more source

Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin

Green Synthesis and Catalysis, 2021
A first palladium-catalyzed asymmetric intramolecular Heck reaction for the construction 3,4-dihydro-1-(2H)-isoquinolinone containing the quaternary carbon chiral center has been developed.
Sanliang Li, Qiaoyu Chen, Zhan-Ming Zhang, Junliang Zhang   +3 more
doaj   +1 more source