Results 31 to 40 of about 14,677 (287)

Methyl N-(3-cyanopicolinoyl)-l-tryptophanate

Acta Crystallographica Section E, 2013
In the title compound, C19H16N4O3, the stereocenter has an l configuration; l-tryptophan methyl ester hydrochloride being used as a starting material. The indole ring system and the pyridine ring are inclined to one another by 13.55 (14)°.
Volodymyr Medviediev, Axelle Arrault, Zoia Voitenko, Olga Ovdiichuk, Olga Hordiyenko   +4 more
doaj   +1 more source

Formal Total Synthesis of Salvinorin A

ChemistryOpen, 2022
The generation of the quaternary stereocenter at the C9 position of salvinorin A precursors by the Claisen rearrangement was investigated. The required allyl alcohol was prepared from a Wieland‐Miescher ketone using a known γ‐hydroxylation, reduction of ...
Marc Halang, Prof. Dr. Martin E. Maier
doaj   +1 more source

Synthesis and Stereochemical Characterization of a Novel Chiral α-Tetrazole Binaphthylazepine Organocatalyst

Molecules, 2022
A novel α-tetrazole-substituted 1,1′-binaphthylazepine chiral catalyst has been synthesized and its absolute configuration has been determined by DFT computational analysis of the vibrational circular dichroism (VCD) spectrum of its precursor.
Assunta Summa, Patrizia Scafato, Sandra Belviso, Guglielmo Monaco, Riccardo Zanasi, Giovanna Longhi, Sergio Abbate, Stefano Superchi   +7 more
doaj   +1 more source

Rapid Synthesis of the Spiroketal Subunit of Neaumycin B: Stereochemical Aspects of Singly Anomeric Spiroketals and Proposal for a Stereocenter Reassignment. [PDF]

Org Lett
Healy AE, Van Engen MD, Cinti NA, Floreancig PE.   +3 more
europepmc   +2 more sources

Chemical Synthesis of Staphyloferrin B Affords Insight into the Molecular Structure, Iron Chelation, and Biological Activity of a Polycarboxylate Siderophore Deployed by the Human Pathogen [PDF]

, 2015
Staphyloferrin B (SB) is a citrate-based polycarboxylate siderophore produced and utilized by the human pathogen Staphylococcus aureus for acquiring iron when colonizing the vertebrate host.
Abergel R. J., Andrews N. C., Banerjee S., Barbeau K., Beasley F. C., Beasley F. C., Beasley F. C., Beasley F. C., Bhatt G., Bugdahn N., Carlsen P. H. J., Cassat J. E., Challis G. L., Chambers H. F., Cheung J., Cheung J., Chu B. C., Connelly N. G., Crosa J. H., Dale S. E., Dale S. E., DeDent A., Drechsel H., Eckelbarger J. D., Elizabeth M. Nolan, Fey P. D., Ford S., Friedman D. B., Gilis A., Grigg J. C., Haag H., Hammer N. D., Hannauer M., Hanses F., Harris W. R., Hider R. C., Janssen P. J., Julie L. H. Madsen, Kobylarz M. J., Kobylarz M. J., Konetschny-Rapp S., Küpper F. C., Lindsay J. A., Lindsay J. A., Makey D. G., Martin R. B., McGavin M. J., Meiwes J., Mergeay M., Milner S. J., Modun B., Münzinger M., Ozawa T. C., Park R.-Y., Pollack S., Schwyn B., Sebulsky M. T., Seebach D., Seyedsayamdost M. R., Sheldon J. R., Sheldon J. R., Shin S. H., Takeuchi Y., Timothy C. Johnstone, Tripathi A.   +64 more
core   +2 more sources

Oxidative allylic rearrangement of cycloalkenols: Formal total synthesis of enantiomerically pure trisporic acid B

Beilstein Journal of Organic Chemistry, 2011
Enantiomerically highly enriched unsaturated β-ketoesters bearing a quaternary stereocenter can be utilized as building blocks for the synthesis of natural occurring terpenes, i. a., trisporic acid and its derivatives. An advanced building block has been
Silke Dubberke, Muhammad Abbas, Bernhard Westermann   +2 more
doaj   +1 more source

Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity

Angewandte Chemie, EarlyView.
Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser, Sarah Heinicke, Sarah E. O'Connor, Maite Colinas   +3 more
wiley   +2 more sources

2S-(1RS-benzyloxy-hex-5-enyl)-2,3-dihydro-1,4-benzodioxine

Molbank
In medicinal chemistry, the precise configuration of molecules is a crucial determinant of their pharmacological properties. Hence, the introduction of a new chiral center during the synthetic pathway involves the assignment of configuration.
Angelica Artasensi, Laura Fumagalli
doaj   +1 more source

Garner’s aldehyde as a versatile intermediate in the synthesis of enantiopure natural products

Beilstein Journal of Organic Chemistry, 2013
Since its introduction to the synthetic community in 1984, Garner’s aldehyde has gained substantial attention as a chiral intermediate for the synthesis of numerous amino alcohol derivatives.
Mikko Passiniemi, Ari M.P. Koskinen
doaj   +1 more source

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation [PDF]

, 2014
Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of “classic” natural product target molecules. This publication highlights recent methods for setting quaternary and
Behenna, Douglas C., Kim, Jimin, Liniger, Marc, Liu, Yiyang, Malette, Jacquie, McFadden, Ryan M., Mohr, Justin T., Reeves, Corey M., Roizen, Jennifer L., Seto, Masaki, Stoltz, Brian M., Virgil, Scott C.   +11 more
core   +3 more sources