Results 41 to 50 of about 14,677 (287)
Angewandte Chemie, EarlyView.The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Methyl substitution positions on the nylon‐6 backbone markedly affect crystallizability, thermomechanical properties, and recyclability of the resulting atactic nylon‐6 variants. While γ‐methyl substitution gives an amorphous nylon, all other four methyl‐substitution positions (α, β, δ, and ε) afford, unexpectedly, crystalline nylons, showing tacticity‐
Jun‐Jie Tian +9 more
wiley +2 more sources
Extensive structure‐activity relationship study of albicidin’s C‐terminal dipeptidic p‐aminobenzoic acid moiety [PDF]
, 2019 Albicidin is a recently described natural product that strongly inhibits bacterial DNA gyrase. The pronounced activity, particularly against Gram‐negative bacteria, turns it into a promising lead structure for an antibacterial drug.
Behroz, Iraj +7 more
core +1 more source
Forging Fluorine-Containing Quaternary Stereocenters by a Light-Driven Organocatalytic Aldol Desymmetrization Process [PDF]
, 2017 Reported herein is a light-triggered organocatalytic strategy for the desymmetrization of achiral 2-fluoro-substi- tuted cyclopentane-1,3-diketones.
Ametamey +49 more
core +2 more sources
Enantioselective Construction of Tertiary Fluoride Stereocenters by Organocatalytic Fluorocyclization [PDF]
Journal of the American Chemical Society, 2020 1,1-Disubstituted styrenes with internal oxygen and nitrogen nucleophiles undergo oxidative fluorocyclization reactions with in situ generated chiral iodine(III)-catalysts. The resulting fluorinated tetrahydrofurans and pyrrolidines contain a tertiary carbon-fluorine stereocenter.
Qiang Wang +6 more
openaire +2 more sources
Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to Five-, Six-, and Seven-Membered β-Substituted Cyclic Enones: Enantioselective Construction of All-Carbon Quaternary Stereocenters [PDF]
, 2011 The first enantioselective Pd-catalyzed construction of all-carbon quaternary stereocenters via 1,4-addition of arylboronic acids to β-substituted cyclic enones is reported. Reaction of a wide range of arylboronic acids and cyclic enones using a catalyst
Gatti, Michele +3 more
core +2 more sources
Catalytic enantioselective synthesis of quaternary carbon stereocentres. [PDF]
, 2014 Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single ...
Overman, Larry E, Quasdorf, Kyle W
core
Advanced Science, EarlyView.An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou +9 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2016 An investigation on the stereoselective cascade sulfa-Michael/aldol reaction of nitroalkenes and commercially available 1,4-dithiane-2,5-diol to 3,4,5-substituted tetrahydrothiophenes, bearing a quaternary stereocenter, is presented.
Sara Meninno +4 more
doaj +1 more source
A Palladium-Catalyzed Vinylcyclopropane (3 + 2) Cycloaddition Approach to the Melodinus Alkaloids [PDF]
, 2011 A palladium-catalyzed (3 + 2) cycloaddition of a vinylcyclopropane and a β-nitrostyrene is employed to rapidly assemble the cyclopentane core of the Melodinus alkaloids.
Goldberg, Alexander F. G. +1 more
core +2 more sources