Results 1 to 10 of about 53,595 (218)
CycloPepper: a machine learning platform for predicting cyclization outcomes and optimizing synthesis of therapeutic cyclopeptides [PDF]
Nature CommunicationsCyclic peptides exhibit remarkable stability, membrane permeability, and binding affinity, positioning them as promising therapeutics. However, their synthesis, particularly on-resin head-to-tail cyclization, remains challenging, with cyclization site ...
Yourong Pan +5 more
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A study towards the synthesis of (-)-atrop-abyssomicin C core [PDF]
Journal of the Serbian Chemical Society, 2021 An attempt to synthesize the cyclohexane core of antibiotic abyssomicin C is described. The initial, protecting group-free approach (relying on internal protection) failed and had to be modified, in order to allow for efficient deprotection of the acid ...
Saičić Radomir N., Trmčić Milena
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Polymer Testing, 2021 Cyclization reaction of poly(acrylonitrile-co-2-acrylamido-2-methylpropane sulfonic acid) [P(AN-co-AMPS)] copolymer during thermal oxidative stabilization (TOS) process was investigated by FTIR and two dimensional (2D) correlation analysis technique. The
Zhipeng He +8 more
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Applications of transition state calculations in the key cyclization of small molecule natural product synthesis [PDF]
E3S Web of Conferences, 2021 The diversification of the conformation and configuration of the carbocyclic skeleton of natural products is an important reason for the diversity and complexity of the structure of natural products.
Qiu Rongxiang
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Harnessing the cyclization strategy for new drug discovery
Acta Pharmaceutica Sinica B, 2022 The design of new ligands with high affinity and specificity against the targets of interest has been a central focus in drug discovery. As one of the most commonly used methods in drug discovery, the cyclization represents a feasible strategy to ...
Kai Tang +4 more
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6-Endo-dig cyclization: Flexible enforce to develop synthetic route in organic syntheses
Results in Chemistry, 2023 The organic ring closure reaction of diverse acyclic compounds is governed mostly by the Baldwin rule. The ring closure compounds shows emergent application.
Vembu Yogeshwaran +3 more
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Influence of Monomer Sequence on the Cyclization Behavior of Poly(acrylonitrile-co-acrylamide)
Applied Sciences, 2023 In this research, we have developed the approach to controlled synthesis of acrylonitrile-acrylamide copolymers with narrow molecular weight distribution and various monomer sequence distributions.
Roman V. Toms +5 more
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SynOpen, 2022 We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of ...
Mojtaba Ayoubi +5 more
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Communications Chemistry, 2023 The biomimetic two-phase strategy employing polyene cyclization and subsequent oxidation/substitution is an effective approach for divergent syntheses of [6-6-6]-tricyclic diterpenes.
Riichi Hashimoto +3 more
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Study on by-products synthesis of powder coating polyester resin catalyzed by organotin
e-Polymers, 2023 In the production of powder-coating polyester, a strong odor emanates from the water, prompting us to investigate its composition and origin. We studied the process of powder coating epoxy/polyester 50/50, which employs butyl tin tris (2-ethyl hexanoate)
Yang YuCheng, Di Chao, Wang TingWei
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