Results 1 to 10 of about 56,559 (262)
Electrophilic Cyclization of Diterpenoids [PDF]
Chemistry Journal of Moldova, 2006 A review of diterpenoid cyclization initiated by electrophilic reagents is provided. Conventional protonic and Lewis acids are examined along with superacids as initiators of cyclization cascade. An emphasis is placed on the use of cyclization reactions as a tool for the synthesis of compounds with potential practical utility.
Veaceslav Kulciţki +3 more
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A study towards the synthesis of (-)-atrop-abyssomicin C core [PDF]
Journal of the Serbian Chemical Society, 2021 An attempt to synthesize the cyclohexane core of antibiotic abyssomicin C is described. The initial, protecting group-free approach (relying on internal protection) failed and had to be modified, in order to allow for efficient deprotection of the acid ...
Saičić Radomir N., Trmčić Milena
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Polymer Testing, 2021 Cyclization reaction of poly(acrylonitrile-co-2-acrylamido-2-methylpropane sulfonic acid) [P(AN-co-AMPS)] copolymer during thermal oxidative stabilization (TOS) process was investigated by FTIR and two dimensional (2D) correlation analysis technique. The
Zhipeng He +8 more
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Harnessing the cyclization strategy for new drug discovery
Acta Pharmaceutica Sinica B, 2022 The design of new ligands with high affinity and specificity against the targets of interest has been a central focus in drug discovery. As one of the most commonly used methods in drug discovery, the cyclization represents a feasible strategy to ...
Kai Tang +4 more
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To Cyclize or Not To Cyclize: Catching Enzyme Evolution in the Act [PDF]
ACS Chemical Biology, 2009 If you look at the biggest genes in soil and marine bacteria, you tend to see the chemical blueprints for making natural products such as peptides and polyketides. Over the past decade, collective efforts of enzymologists working with synthetic and analytical chemists have been catching up with the data dump from microbial genome sequencing.
Bradley S, Evans, Neil L, Kelleher
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6-Endo-dig cyclization: Flexible enforce to develop synthetic route in organic syntheses
Results in Chemistry, 2023 The organic ring closure reaction of diverse acyclic compounds is governed mostly by the Baldwin rule. The ring closure compounds shows emergent application.
Vembu Yogeshwaran +3 more
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Cyclization-activated Prodrugs [PDF]
Molecules, 2007 Many drugs suffer from an extensive first-pass metabolism leading to druginactivation and/or production of toxic metabolites, which makes them attractive targets forprodrug design. The classical prodrug approach, which involves enzyme-sensitive covalentlinkage between the parent drug and a carrier moiety, is a well established strategy toovercome ...
Paula Gomes, Nuno Vale, Rui Moreira
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Influence of Monomer Sequence on the Cyclization Behavior of Poly(acrylonitrile-co-acrylamide)
Applied Sciences, 2023 In this research, we have developed the approach to controlled synthesis of acrylonitrile-acrylamide copolymers with narrow molecular weight distribution and various monomer sequence distributions.
Roman V. Toms +5 more
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Communications Chemistry, 2023 The biomimetic two-phase strategy employing polyene cyclization and subsequent oxidation/substitution is an effective approach for divergent syntheses of [6-6-6]-tricyclic diterpenes.
Riichi Hashimoto +3 more
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Study on by-products synthesis of powder coating polyester resin catalyzed by organotin
e-Polymers, 2023 In the production of powder-coating polyester, a strong odor emanates from the water, prompting us to investigate its composition and origin. We studied the process of powder coating epoxy/polyester 50/50, which employs butyl tin tris (2-ethyl hexanoate)
Yang YuCheng, Di Chao, Wang TingWei
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