Results 31 to 40 of about 3,572,666 (356)
The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]
, 2017 Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna +3 more
core +2 more sources
Gastroenterology Research and Practice, 2012 Aim. The study was to investigate the metabolic profile of urine metabolites and to elucidate their clinical significance in patients with colorectal cancer. Methods. Colorectal cancers from early stage and advanced stage were used in this study.
Jin-Lian Chen +6 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2021 A facile synthesis of 2,4-diaryl-9-chloro-5,6,7,8-tetrahydroacridine derivatives is reported which is based on POCl3-mediated cyclodehydration followed by double Suzuki–Miyaura cross-coupling.
Najeh Tka +4 more
doaj +1 more source
Indole diterpenoid natural products as the inspiration for new synthetic methods and strategies. [PDF]
, 2017 Indole terpenoids comprise a large class of natural products with diverse structural topologies and a broad range of biological activities. Accordingly, indole terpenoids have and continue to serve as attractive targets for chemical synthesis.
Corsello, Michael A +2 more
core +1 more source
Indonesian Journal of Chemistry, 2010 Two steps transformation of (+)-citronellal, cyclization and hydrogenation, on ZnBr2/γ-Al2O3 and Ni/γ-Al2O3 catalyst have been realized with the selectivity to cyclization products (isopulegols) was very high (yield up to ~92.58%) over ZnBr2/γ-Al2O3 ...
Elvina Dhiaul Iftitah +3 more
doaj +1 more source
Pharmaceuticals, 2021 This review concerns the synthesis and biological activities of pyrazino[1,2-a]indoles and pyrazino[1,2-a]indol-1-ones reported since 1997 and the discovery of biological activity of pyrazinoindole derivatives.
Kena Zhang +4 more
doaj +1 more source
Asymmetric Redox-Neutral Radical Cyclization Catalyzed by Flavin-Dependent ‘Ene’-Reductases
Nature Chemistry, 2019 Flavin-dependent ‘ene’-reductases (EREDs) are exquisite catalysts for effecting stereoselective reductions. Although these reactions typically proceed through a hydride transfer mechanism, we recently found that EREDs can also catalyse reductive ...
M. Black +6 more
semanticscholar +1 more source
Simultaneous cyclization and derivatization of peptides using cyclopentenediones [PDF]
, 2017 Unprotected linear peptides containing N-terminal cysteines and another cysteine residue can be simultaneously cyclized and derivatized using 2,2-disubstituted cyclopentenediones. High yields of cyclic peptide conjugates may be obtained in short reaction
Agramunt, Jordi +4 more
core +2 more sources
Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-didehydroxyisogarcinol and (±)-6,30-epi-garcimultiflorone A utilizing highly diastereoselective, Lewis acid-controlled cyclizations [PDF]
, 2016 The first syntheses of 13,14-didehydroxyisogarcinol (6) and garcimultiflorone A (5) stereoisomers are reported in six steps from a commercially available phloroglucinol.
Boyce, Jonathan H. +2 more
core +1 more source
Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides.
Journal of the American Chemical Society, 2019 Cyclic peptides are drawing wide attentions as potential medium-sized modulators of biomolecular interactions with large binding surfaces. Simple but effective peptide cyclization methods are needed to construct cyclic peptide libraries by both peptide ...
Yue Zhang +3 more
semanticscholar +1 more source