Results 11 to 20 of about 3,572,666 (356)
CycloPepper: a machine learning platform for predicting cyclization outcomes and optimizing synthesis of therapeutic cyclopeptides [PDF]
Nature CommunicationsCyclic peptides exhibit remarkable stability, membrane permeability, and binding affinity, positioning them as promising therapeutics. However, their synthesis, particularly on-resin head-to-tail cyclization, remains challenging, with cyclization site ...
Yourong Pan +5 more
doaj +2 more sources
Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals
Nature Chemistry, 2017 The rapid generation of molecular complexity from simple starting materials is a key challenge in synthesis. Enantioselective radical cyclization cascades have the potential to deliver complex, densely packed, polycyclic architectures, with control of three-dimensional shape, in one step.
Nicolas Kern +3 more
openaire +6 more sources
Oxidative Cyclization in Natural Product Biosynthesis
Chemical Reviews, 2017 Yi Zou, Kenji Watanabe, Yi Tang
exaly +2 more sources
A study towards the synthesis of (-)-atrop-abyssomicin C core [PDF]
Journal of the Serbian Chemical Society, 2021 An attempt to synthesize the cyclohexane core of antibiotic abyssomicin C is described. The initial, protecting group-free approach (relying on internal protection) failed and had to be modified, in order to allow for efficient deprotection of the acid ...
Saičić Radomir N., Trmčić Milena
doaj +1 more source
Polymer Testing, 2021 Cyclization reaction of poly(acrylonitrile-co-2-acrylamido-2-methylpropane sulfonic acid) [P(AN-co-AMPS)] copolymer during thermal oxidative stabilization (TOS) process was investigated by FTIR and two dimensional (2D) correlation analysis technique. The
Zhipeng He +8 more
doaj +1 more source
Stereodivergent atom-transfer radical cyclization by engineered cytochromes P450
Science, 2021 Description Radical cyclization made easy Metalloenzymes contain metal cofactors that can sometimes be exploited to catalyze reactions distinct from their natural function.
Qi Zhou +4 more
semanticscholar +1 more source
Harnessing the cyclization strategy for new drug discovery
Acta Pharmaceutica Sinica B, 2022 The design of new ligands with high affinity and specificity against the targets of interest has been a central focus in drug discovery. As one of the most commonly used methods in drug discovery, the cyclization represents a feasible strategy to ...
Kai Tang +4 more
doaj +1 more source
Cyclization-activated Prodrugs [PDF]
Molecules, 2007 Many drugs suffer from an extensive first-pass metabolism leading to druginactivation and/or production of toxic metabolites, which makes them attractive targets forprodrug design. The classical prodrug approach, which involves enzyme-sensitive covalentlinkage between the parent drug and a carrier moiety, is a well established strategy toovercome ...
Paula Gomes, Nuno Vale, Rui Moreira
openaire +5 more sources
6-Endo-dig cyclization: Flexible enforce to develop synthetic route in organic syntheses
Results in Chemistry, 2023 The organic ring closure reaction of diverse acyclic compounds is governed mostly by the Baldwin rule. The ring closure compounds shows emergent application.
Vembu Yogeshwaran +3 more
doaj +1 more source
Influence of Monomer Sequence on the Cyclization Behavior of Poly(acrylonitrile-co-acrylamide)
Applied Sciences, 2023 In this research, we have developed the approach to controlled synthesis of acrylonitrile-acrylamide copolymers with narrow molecular weight distribution and various monomer sequence distributions.
Roman V. Toms +5 more
doaj +1 more source