Results 11 to 20 of about 121,287 (309)
A construction of 4,4-spirocyclic γ-lactams by tandem radical cyclization with carbon monoxide [PDF]
, 2013 A straightforward synthesis of 4,4-spirocyclic indol gamma-lactams by tandem radical cyclization of iodoaryl allyl azides with CO was achieved. The reaction of iodoaryl allyl azides, TTMSS and AIBN under CO pressure (80 atm) in THF at 80 degrees C gave ...
Uenoyama, Yoshitaka +6 more
core +4 more sources
A study towards the synthesis of (-)-atrop-abyssomicin C core [PDF]
Journal of the Serbian Chemical Society, 2021 An attempt to synthesize the cyclohexane core of antibiotic abyssomicin C is described. The initial, protecting group-free approach (relying on internal protection) failed and had to be modified, in order to allow for efficient deprotection of the acid ...
Saičić Radomir N., Trmčić Milena
doaj +1 more source
Polymer Testing, 2021 Cyclization reaction of poly(acrylonitrile-co-2-acrylamido-2-methylpropane sulfonic acid) [P(AN-co-AMPS)] copolymer during thermal oxidative stabilization (TOS) process was investigated by FTIR and two dimensional (2D) correlation analysis technique. The
Zhipeng He +8 more
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Harnessing the cyclization strategy for new drug discovery
Acta Pharmaceutica Sinica B, 2022 The design of new ligands with high affinity and specificity against the targets of interest has been a central focus in drug discovery. As one of the most commonly used methods in drug discovery, the cyclization represents a feasible strategy to ...
Kai Tang +4 more
doaj +1 more source
Enantioselective radical cascade cyclization via Ti-catalyzed redox relay [PDF]
, 2023 Radical cascade cyclization reactions provide an efficient method for the construction of polycyclic architectures with multiple stereogenic centers. However, achieving enantioselectivity control of this type of reaction is a challenging task.
Wen, Zhang, Peng, Yu, Song, Lin
core +1 more source
Programmed Polyene Cyclization Enabled by Chromophore Disruption [PDF]
, 2022 A versatile polyene cyclization strategy was developed that exploits conjugated -ionyl derivatives. Photomediated disruption of the extended -system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization ...
Vitalii, Basistyi +4 more
core +2 more sources
Ligand-Assisted Gold-Catalyzed Efficient Alkynylative Cyclization with Terminal Alkynes Using H2O2 as Oxidant [PDF]
, 2022 The gold-catalyzed cyclization-functionalization is a powerful approach to construct high-value organic molecules. However, current strategies mainly rely on expensive external oxidants or pre-functionalized substrates, which exhibit low atom economy and
Matthias, Rudolph +8 more
core +2 more sources
6-Endo-dig cyclization: Flexible enforce to develop synthetic route in organic syntheses
Results in Chemistry, 2023 The organic ring closure reaction of diverse acyclic compounds is governed mostly by the Baldwin rule. The ring closure compounds shows emergent application.
Vembu Yogeshwaran +3 more
doaj +1 more source
To Cyclize or Not To Cyclize: Catching Enzyme Evolution in the Act [PDF]
ACS Chemical Biology, 2009 If you look at the biggest genes in soil and marine bacteria, you tend to see the chemical blueprints for making natural products such as peptides and polyketides. Over the past decade, collective efforts of enzymologists working with synthetic and analytical chemists have been catching up with the data dump from microbial genome sequencing.
Bradley S, Evans, Neil L, Kelleher
openaire +2 more sources
Influence of Monomer Sequence on the Cyclization Behavior of Poly(acrylonitrile-co-acrylamide)
Applied Sciences, 2023 In this research, we have developed the approach to controlled synthesis of acrylonitrile-acrylamide copolymers with narrow molecular weight distribution and various monomer sequence distributions.
Roman V. Toms +5 more
doaj +1 more source