Hypervalent iodine-mediated cyclization of bishomoallylamides to prolinols [PDF]
Beilstein Journal of Organic ChemistryA change in mechanism was observed in the hypervalent iodine-mediated cyclization of N-alkenylamides when the carbon chain between the alkene and the amide increased from two to three atoms.
Smaher E. Butt +3 more
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Enantioselective radical cascade cyclization via Ti-catalyzed redox relay [PDF]
, 2023 Radical cascade cyclization reactions provide an efficient method for the construction of polycyclic architectures with multiple stereogenic centers. However, achieving enantioselectivity control of this type of reaction is a challenging task.
Wen, Zhang, Peng, Yu, Song, Lin
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Programmed Polyene Cyclization Enabled by Chromophore Disruption [PDF]
, 2022 A versatile polyene cyclization strategy was developed that exploits conjugated -ionyl derivatives. Photomediated disruption of the extended -system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization ...
Vitalii, Basistyi +4 more
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Ligand-Assisted Gold-Catalyzed Efficient Alkynylative Cyclization with Terminal Alkynes Using H2O2 as Oxidant [PDF]
, 2022 The gold-catalyzed cyclization-functionalization is a powerful approach to construct high-value organic molecules. However, current strategies mainly rely on expensive external oxidants or pre-functionalized substrates, which exhibit low atom economy and
Matthias, Rudolph +8 more
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A Phage-Compatible Strategy to Access Macrocyclic Peptides Featuring Asymmetric Molecular Scaffolds as Cyclization Units [PDF]
, 2021 The cyclization of peptides appended onto proteins or whole bacteriophages is typically achieved via disulfide formation, the use of symmetric crosslinkers or the incorporation of noncanonical amino acids.
Johan, Hekelaar +2 more
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Cu-Catalyzed Cyclization/Coupling of Alkenyl Aldimines. Indolization of Aldehydes, Anilines and Arylzinc Reagents [PDF]
, 2022 We report a Cu(II)-catalyzed cyclization/coupling of alkenyl aldimines with arylzinc reagents to create complex indole-3-diarylmethane derivatives. The aldimines are readily available by simple dehydration, making the process a formal three-component ...
Nicholas C., Secosky +6 more
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Cytochrome P450-Mediated Cyclization in Eunicellane-Derived Diterpenoid Biosynthesis [PDF]
, 2023 Terpene cyclization, one of the most complex chemical reactions in nature, is generally catalyzed by two classes of terpene cyclases (TCs). Cytochrome P450s that act as unexpected TC-like enzymes are known but are very rare.
Liao-Bin, Dong +9 more
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Silver-Catalyzed Tandem Cyclization for Syntheses of Azaoxa- and Diazaspirocycles [PDF]
, 2022 1-Azaspirocycles are important structures present in many drugs and natural products. This paper describes the silver-catalyzed tandem cyclization strategy, which provides atom-economical access to various azaoxa- and diazaspirocycles from alkynes ...
Momoka, Shimaoka, Masahiro, Sai
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A construction of 4,4-spirocyclic γ-lactams by tandem radical cyclization with carbon monoxide [PDF]
, 2013 A straightforward synthesis of 4,4-spirocyclic indol gamma-lactams by tandem radical cyclization of iodoaryl allyl azides with CO was achieved. The reaction of iodoaryl allyl azides, TTMSS and AIBN under CO pressure (80 atm) in THF at 80 degrees C gave ...
Uenoyama, Yoshitaka +13 more
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, 2023 A computational study of the reaction mechanism of aryl propiolates with various radicals is examined employing DFT and coupled-cluster methods at the DLPNO-CCSD(T)/cc-pVTZ//M062X-6-311G(d,p) level.
Meryem Fıstıkçı +1 more
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