Results 21 to 30 of about 121,287 (309)
Cyclization-activated Prodrugs [PDF]
Molecules, 2007 Many drugs suffer from an extensive first-pass metabolism leading to druginactivation and/or production of toxic metabolites, which makes them attractive targets forprodrug design. The classical prodrug approach, which involves enzyme-sensitive covalentlinkage between the parent drug and a carrier moiety, is a well established strategy toovercome ...
Paula Gomes, Nuno Vale, Rui Moreira
openaire +5 more sources
Cytochrome P450-Mediated Cyclization in Eunicellane-Derived Diterpenoid Biosynthesis [PDF]
, 2023 Terpene cyclization, one of the most complex chemical reactions in nature, is generally catalyzed by two classes of terpene cyclases (TCs). Cytochrome P450s that act as unexpected TC-like enzymes are known but are very rare.
Liao-Bin, Dong +19 more
core +2 more sources
Communications Chemistry, 2023 The biomimetic two-phase strategy employing polyene cyclization and subsequent oxidation/substitution is an effective approach for divergent syntheses of [6-6-6]-tricyclic diterpenes.
Riichi Hashimoto +3 more
doaj +1 more source
Study on by-products synthesis of powder coating polyester resin catalyzed by organotin
e-Polymers, 2023 In the production of powder-coating polyester, a strong odor emanates from the water, prompting us to investigate its composition and origin. We studied the process of powder coating epoxy/polyester 50/50, which employs butyl tin tris (2-ethyl hexanoate)
Yang YuCheng, Di Chao, Wang TingWei
doaj +1 more source
Energies, 2023 Composite solid electrolytes (CSEs), often incorporating succinonitrile (SCN), offer promi I confirm sing solutions for improving the performance of all-solid-state batteries.
Hyewoo Noh +5 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2021 A facile synthesis of 2,4-diaryl-9-chloro-5,6,7,8-tetrahydroacridine derivatives is reported which is based on POCl3-mediated cyclodehydration followed by double Suzuki–Miyaura cross-coupling.
Najeh Tka +4 more
doaj +1 more source
Cu-Catalyzed Cyclization/Coupling of Alkenyl Aldimines. Indolization of Aldehydes, Anilines and Arylzinc Reagents [PDF]
, 2022 We report a Cu(II)-catalyzed cyclization/coupling of alkenyl aldimines with arylzinc reagents to create complex indole-3-diarylmethane derivatives. The aldimines are readily available by simple dehydration, making the process a formal three-component ...
Nicholas C., Secosky +6 more
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Gastroenterology Research and Practice, 2012 Aim. The study was to investigate the metabolic profile of urine metabolites and to elucidate their clinical significance in patients with colorectal cancer. Methods. Colorectal cancers from early stage and advanced stage were used in this study.
Jin-Lian Chen +6 more
doaj +1 more source
Pharmaceuticals, 2021 This review concerns the synthesis and biological activities of pyrazino[1,2-a]indoles and pyrazino[1,2-a]indol-1-ones reported since 1997 and the discovery of biological activity of pyrazinoindole derivatives.
Kena Zhang +4 more
doaj +1 more source
, 2023 A computational study of the reaction mechanism of aryl propiolates with various radicals is examined employing DFT and coupled-cluster methods at the DLPNO-CCSD(T)/cc-pVTZ//M062X-6-311G(d,p) level.
Meryem Fıstıkçı +1 more
core +1 more source