Results 41 to 50 of about 3,572,666 (356)

Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones [PDF]

, 2009
A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thio¬pyrimidinones, respectively.
Bernardini, Martina, Botta, Maurizio, Castagnolo, Daniele, Pagano, Mafalda   +3 more
core   +1 more source

Changing the topology of protein backbone: the effect of backbone cyclization on the structure and dynamics of a SH3 domain

Frontiers in Chemistry, 2015
Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function.
Frank H Schumann, Ranjani eVaradan, Praveen Pudiavettil Tayakuniyil, Jennifer Hall Grossman, Julio A Camarero, Julio A Camarero, David eFushman   +6 more
doaj   +1 more source

Photoredox‐Catalyzed Cyclobutane Synthesis by a Deboronative Radical Addition–Polar Cyclization Cascade

Angewandte Chemie, 2019
Photoredox‐catalyzed methylcyclobutanations of alkylboronic esters are described. The reactions proceed through single‐electron transfer induced deboronative radical addition to an electron‐deficient alkene followed by single‐electron reduction and polar
Chao Shu, Adam Noble, V. Aggarwal
semanticscholar   +1 more source

Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids [PDF]

, 2015
A unified strategy for enantioselective total synthesis of all stereoisomers of the [2+2] family of quadrigemine alkaloids is reported. In this approach, two enantioselective intramolecular Heck reactions are carried out at the same time on precursors ...
Canham, SM, Hafensteiner, BD, Lebsack, AD, May-Dracka, TL, Nam, S, Overman, LE, Stearns, BA   +6 more
core   +4 more sources

Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters

Frontiers in Chemistry, 2021
Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan, Anna Meschkov, Anna Meschkov, Ute Schepers, Ute Schepers, Stefan Bräse, Stefan Bräse   +6 more
doaj   +1 more source

A generalized theory of semiflexible polymers [PDF]

, 2005
DNA bending on length scales shorter than a persistence length plays an integral role in the translation of genetic information from DNA to cellular function. Quantitative experimental studies of these biological systems have led to a renewed interest in
B. Alberts, D. Shore, H. Kleinert, H. Yamakawa, J. J. Sakurai, J. Widom, L. Finzi, P. Nelson, Paul A. Wiggins, Philip C. Nelson, T. E. Cloutier   +10 more
core   +3 more sources

Enzymatic Bromocyclization of α‐ and γ‐Allenols by Chloroperoxidase from Curvularia inaequalis

ChemistryOpen, 2022
Vanadate‐dependent chloroperoxidase from Curvularia inaequalis catalyzes 5‐endo‐trig bromocyclizations of α‐allenols to produce valuable halofunctionalized furans as versatile synthetic building blocks. In contrast to other haloperoxidases, also the more
Janne M. Naapuri, Philip K. Wagner, Prof. Dr. Frank Hollmann, Prof. Dr. Jan Deska   +3 more
doaj   +1 more source

Nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole derivatives: Synthesis of pyrrolopyrazinone, pyrrolotriazinone, and pyrrolooxazinone moieties

Beilstein Journal of Organic Chemistry, 2017
Intramolecular nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole esters is described. Efficient routes towards the synthesis of pyrrolopyrazinone, pyrrolotriazinone and pyrrolooxazinone have been developed.
Işıl Yenice, Sinan Basceken, Metin Balci   +2 more
doaj   +1 more source

Exact theory of kinkable elastic polymers [PDF]

, 2004
The importance of nonlinearities in material constitutive relations has long been appreciated in the continuum mechanics of macroscopic rods. Although the moment (torque) response to bending is almost universally linear for small deflection angles, many ...
A. Y. Grosberg, C. A. Sucato, D. Shore, E. N. Trifonov, G. B. Arfken, H. Yamakawa, J. Bernet, J. J. Sakurai, L. D. Landau, O. Kratky, P. C. Nelson, Paul A. Wiggins, Philip C. Nelson, R. P. Feynman, Rob Phillips   +14 more
core   +5 more sources

Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes

Biomolecules, 2020
Structurally diverse carbazole alkaloids are valuable due to their pharmaceutical properties and have been isolated from nature. Experimental knowledge on carbazole biosynthesis is limited. The latest development of in silico analysis of the biosynthetic
Masaya Kobayashi, Tomohisa Kuzuyama
doaj   +1 more source