Results 41 to 50 of about 121,287 (309)

‐Cyclization [PDF]

, 2020
We report herein a nonbiomimetic strategy for the total synthesis of the plicamine‐type alkaloids zephycarinatines C and D. The key feature of the synthesis is a stereoselective reductive radical ipso‐cyclization using visible‐light‐mediated photoredox ...
Shinya Oishi, Oishi, Shinya, Takaaki Kawabe, Ichimura, Atsuhiko, Shinsuke Inuki, Inuki, Shinsuke, Takeuchi, Haruka, Ohno, Hiroaki, Atsuhiko Ichimura, Nakagawa, Kohei, Kohei Nakagawa, Haruka Takeuchi, Hiroaki Ohno, Kawabe, Takaaki   +13 more
core   +1 more source

Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes

Molecules, 2023
Substituent-regulated cyclization of conjugated alkynes with acid catalysis was developed in this paper, and it provides a straightforward synthesis of cyclic-(E)-[3]dendralenes.
Yun-Tao Xia, Ya-Xin Li, Tong-Tong Bi, Wei Lian, Xia Wang, Meng Yan, Tao Guo   +6 more
doaj   +1 more source

The oxime portmanteau motif : released heteroradicals undergo incisive EPR interrogation and deliver diverse heterocycles [PDF]

, 2014
OA funded through the RCUK OA block grant.Selective syntheses are now available for compounds of many classes, based on C-centered radicals, exploiting a diverse range of mechanisms.
John C. Walton, Walton, John Christopher, Walton, John Christopher; id_orcid   +2 more
core   +1 more source

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

Molecules, 2005
Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are
Patrice Vanelle, Michel P. Crozet, Pascal George, Maxime D. Crozet   +3 more
doaj   +1 more source

Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals

Nature Chemistry, 2017
The rapid generation of molecular complexity from simple starting materials is a key challenge in synthesis. Enantioselective radical cyclization cascades have the potential to deliver complex, densely packed, polycyclic architectures, with control of three-dimensional shape, in one step.
Nicolas Kern, Mateusz P. Plesniak, Joseph J. W. McDouall, David J. Procter   +3 more
openaire   +5 more sources

Computational Investigation of Mechanism and Selectivity in (3+2) Cycloaddition Reactions Involving Azaoxyallyl Cations

Reactions
Azaoxyallyl cations, as novel and versatile three-atom components, have been widely utilized in cycloaddition reactions, with the competition between O- and N-cyclization pathways remaining a key research focus.
Wei Zhou, Lei Zhang, Guixian Liu, Xiaosi Ma, Xiangtai Meng   +4 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization

, 2018
Inspired by the dicationic nature of the electrophilic fluorinating reagent, Selectfluor (1), we rationally designed a series of dicarboxylic acid precatalysts (2), which, when deprotonated, act as anionic phase-transfer catalysts for asymmetric ...
Yuji Kawato (1548028), Hiromichi Egami (1548016), Daiki Rouno (4847134), Yoshitaka Hamashima (1548019), Hitomi Sato (4847128), Tomoki Niwa (4847131), Ryo Hotta (3522902)   +6 more
core   +1 more source

An Iodine-Vapor-Induced Cyclization in a Crystalline Molecular Flask [PDF]

, 2016
A vapor‐induced cyclization has been observed in the host environment of a crystalline molecular flask (CMF), within which 1,8‐bis(2‐phenylethynyl)naphthalene (bpen), a diarenynyl system primed for cyclization, was exposed to iodine vapor to yield the ...
Andrew D. Burrows, Knichal, Jane V, Shepherd, H.J., Paul R. Raithby, Jane V. Knichal, Chick C. Wilson, Raithby, Paul R, Knichal, Jane V., Shepherd, Helena J, Burrows, Andrew D, Wilson, Chick C, Helena J. Shepherd, Gee, William J., Gee, William J, Wilson, Chick C., Burrows, Andrew D., William J. Gee, Raithby, Paul R.   +17 more
core   +1 more source