Results 61 to 70 of about 56,559 (262)

A Novel Aza-Nazarov Cyclization of Quinazolinonyl Enones: A Facile Access to CRing Substituted Vasicinones and Luotonins [PDF]

, 2019
Our pre-print titled " A Novel Aza-Nazarov Cyclization of Quinazolinonyl Enones: A Facile Access to C-Ring Substituted Vasicinones and Luotonins" describes:· design and development of a novel variant of aza-Nazarov reaction of quinazolinonyl enones as a ...
Sivappa, Rasapalli, Jeffrey A, Boerth, Yanchang, Huang, Sergey N, Savinov, Vamshisammeta Reddy, Sammeta, James A, Golen, Zachary F, Murphy   +6 more
core   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

A reagent-free, sequence-dependent in situ peptide self-cyclization strategy under physiological condition

European Journal of Medicinal Chemistry Reports
Cyclic peptides are an important class of bioactive molecules used as drugs as well as biomolecular probes. Peptide cyclization under the physiological environment, without added chemicals or reagents, would be a highly useful technique for in situ ...
Nibedita Ghosh, Lal Mohan Kundu
doaj   +1 more source

Immunoglobulin Depletion and Recovery Following Blinatumomab in Infants With KMT2A‐Rearranged ALL

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Adding blinatumomab to standard chemotherapy for infants with KMT2A‐rearranged acute B‐cell lymphoblastic leukemia (KMT2A‐r B‐ALL) improves outcomes. Although blinatumomab impairs immunoglobulin G (lgG) production, increasing infection susceptibility, IgG recovery remains poorly understood.
Miguel Vieira Martins, Paola de Lorenzo, Rishi S. Kotecha, Andishe Attarbaschi, Gabriele Escherich, Karsten Nysom, Jan Stary, Alina Ferster, Benoit Brethon, Franco Locatelli, Martin Schrappe, Peggy E. Scholte‐van Houtem, Maria G. Valsecchi, Rob Pieters, Inge M. van der Sluis   +14 more
wiley   +1 more source

‐Cyclization [PDF]

, 2020
We report herein a nonbiomimetic strategy for the total synthesis of the plicamine‐type alkaloids zephycarinatines C and D. The key feature of the synthesis is a stereoselective reductive radical ipso‐cyclization using visible‐light‐mediated photoredox ...
Shinya Oishi, Oishi, Shinya, Takaaki Kawabe, Ichimura, Atsuhiko, Shinsuke Inuki, Inuki, Shinsuke, Takeuchi, Haruka, Ohno, Hiroaki, Atsuhiko Ichimura, Nakagawa, Kohei, Kohei Nakagawa, Haruka Takeuchi, Hiroaki Ohno, Kawabe, Takaaki   +13 more
core   +1 more source

Nickel-catalyzed electrophiles-controlled enantioselective reductive arylative cyclization and enantiospecific reductive alkylative cyclization of 1,6-enynes

Nature Communications
Transition metal-catalyzed asymmetric cyclization of 1,6-enynes is a powerful tool for the construction of chiral nitrogen-containing heterocycles.
Wenfeng Liu, Yunxin Xing, Denghong Yan, Wangqing Kong, Kun Shen   +4 more
doaj   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

Sortase-Mediated Peptide Ligation and Cyclization for Phage Display [PDF]

Macrocyclic peptide library has proven to be an invaluable source for discovering high-affinity ligands for disease-associated proteins. Here we propose a sortase-mediated peptide ligation and one-pot cyclization strategy to generate monocyclic and ...
Zhi-Hui, Cui, Yang, Tang, Zhaocai, Zhou, Yan-Ni, Zhang, Ge-Min, Fang, Hua, Zhang, Xiao-Cui, Wan, Ying, Chen, Feng-Hao, Zheng   +8 more
core   +1 more source

GH172 difructose dianhydride I synthase: A two-stepped journey via glycosylation and cyclization using QM/MM metadynamics [PDF]

, 2023
Difructose dianhydride I synthase/hydrolase (αFFase1) is a member of the family 172 of glycoside hydrolases which catalyzes the reversible transformation of inulobiose into difructose dianhydride I (DFA I).
Kiyotaka, Fujita, Akihiro, Ishiwata, Pedro Alejandro, Sánchez-Murcia, Shinya, Fushinobu, Toma , Kashima, Katsunori, Tanaka, Bruno, Di Geronimo, Santiago, Alonso-Gil   +7 more
core   +1 more source

Consensus Standards and Recommendations for Developmental and Cognitive Surveillance, Screening, and Evaluation in Sickle Cell Disease: Executive Summary From the National Alliance of Sickle Cell Centers Neurocognitive Workgroup

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz, Donna Murdaugh, Andrew M. Heitzer, Jennifer N. Longoria, Wendy Santos‐Modesitt, Arianna Martin, Judy Cavazos, Jeff Schatz, Catherine R. Hoyt, Alison King, Eboni I. Lance, Steven Hardy, Marsha Treadwell   +12 more
wiley   +1 more source