Results 61 to 70 of about 3,572,666 (356)

Free radical cyclizations [PDF]

Pure and Applied Chemistry, 1967
Abstract
openaire   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Hypervalent iodine-mediated cyclization of bishomoallylamides to prolinols

Beilstein Journal of Organic Chemistry
A change in mechanism was observed in the hypervalent iodine-mediated cyclization of N-alkenylamides when the carbon chain between the alkene and the amide increased from two to three atoms.
Smaher E. Butt, Konrad Kepski, Jean-Marc Sotiropoulos, Wesley J. Moran   +3 more
doaj   +1 more source

An Efficient Synthesis of Novel 4-Aryl-2-thioxo-3,4-dihydro-1H-pyrimido[1,2-a][1,3,5]triazin-6(2H)-ones and Their Antibacterial Activity

Molbank, 2022
New substituted 4-aryl-8-methyl-2-thioxo-1,2,3,4-tetrahydro-6H-pyrimido[1,2-a][1,3,5]triazin-6-one 8a–b and ethyl 4-aryl-6-oxo-2-thioxo-1,3,4,6-tetrahydro-2H-pyrimido[1,2-a][1,3,5]triazine-7-carboxylate 8c–e were synthesized by the reaction of the ...
Do Van Quy, Nguyen Van Hung, Nadezhda Stolpovskaya, Aleksey Kruzhilin, Svetlana S. Olshannikova, Marina Holyavka, Vladimir Sulimov, Khidmet Shikhaliev   +7 more
doaj   +1 more source

Protein-Mediated DNA Loops: Effects of Protein Bridge Size and Kinks

, 2005
This paper focuses on the probability that a portion of DNA closes on itself through thermal fluctuations. We investigate the dependence of this probability upon the size r of a protein bridge and/or the presence of a kink at half DNA length.
H. E. Daniels, H. Kleinert, H. Yamakawa, Nicolas Douarche, O. Kratky, Simona Cocco, W. H. Press   +6 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Nickel-catalyzed switchable arylative/endo-cyclization of 1,6-enynes

Nature Communications
Carbo- and heterocycles are frequently used as crucial scaffolds in natural products, fine chemicals, and biologically and pharmaceutically active compounds.
Wenfeng Liu, Wei Li, Weipeng Xu, Minyan Wang, Wangqing Kong   +4 more
doaj   +1 more source

ELECTROPHILIC CYCLIZATION OF DITERPENOIDS [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2006
A review of diterpenoid cyclization initiated by electrophilic reagents is provided. Conventional protonic and Lewis acids are examined along with superacids as initiators of cyclization cascade.
Veaceslav Kulciţki, Marina Grinco, Pavel Vlad, Nicon Ungur   +3 more
doaj  

Biological Consequences of Tightly Bent DNA: The Other Life of a Macromolecular Celebrity [PDF]

, 2006
The mechanical properties of DNA play a critical role in many biological functions. For example, DNA packing in viruses involves confining the viral genome in a volume (the viral capsid) with dimensions that are comparable to the DNA persistence length ...
Garcia, Hernan G., Grayson, Paul, Han, Lin, Inamdar, Mandar, Kondev, Jane, Nelson, Philip C., Phillips, Rob, Widom, Jonathan, Wiggins, Paul A.   +8 more
core   +3 more sources

Catalyst-Dependent Chemoselectivity in the Dirhodium-Catalyzed Cyclization Reactions Between Enodiazoacetamide and Nitrosoarene: A Theoretical Study

Frontiers in Chemistry, 2019
N-O heterocycle compounds play an important role in various fields. Doyle et al. (Cheng et al., 2017) have recently reported an efficient catalyst-controlled selective cyclization reactions of tert-butyldimethylsilyl (TBS)-protected enoldiazoacetamides ...
Yan Zhang, Yongsheng Yang, Ruyu Zhu, Xingyu Wang, Ying Xue   +4 more
doaj   +1 more source