Results 21 to 30 of about 20,067 (277)

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

Molecules, 2023
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists.
Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice   +12 more
doaj   +1 more source

Stereochemistry of the peroxisomal branched-chain fatty acid α- and β-oxidation systems in patients suffering from different peroxisomal disorders

Journal of Lipid Research, 2002
Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid derived from dietary sources and broken down in the peroxisome to pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) via α-oxidation.
S. Ferdinandusse, H. Rusch, A.E.M. van Lint, G. Dacremont, R.J.A. Wanders, P. Vreken   +5 more
doaj   +1 more source

A High-Affinity ⁶⁴Cu-Labeled Ligand for PET Imaging of Hepsin: Design, Synthesis, and Characterization

Pharmaceuticals, 2022
Hepsin, a cell surface serine protease, is a potential biomarker for the detection of prostate cancer due to its high expression in prostate cancer but not in normal prostate.
Ji-Hun Park, Xuran Zhang, Hyunsoo Ha, Jung Young Kim, Joon Young Choi, Kyung-Han Lee, Youngjoo Byun, Yearn Seong Choe   +7 more
doaj   +1 more source

Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies

Marine Drugs, 2022
Iriomoteolide-1a and iriomoteolide-1b are very potent cytotoxic agents, isolated from marine dinoflagellates. We carried out the enantioselective syntheses of the proposed structures of these natural products.
Arun K. Ghosh, Hao Yuan
doaj   +1 more source

Raistrickiones A−E from a Highly Productive Strain of Penicillium raistrickii Generated through Thermo Change

Marine Drugs, 2018
Three new diastereomers of polyketides (PKs), raistrickiones A−C (1–3), together with two new analogues, raistrickiones D and E (4 and 5), were isolated from a highly productive strain of Penicillium raistrickii, which was subjected to an ...
De-Sheng Liu, Xian-Guo Rong, Hui-Hui Kang, Li-Ying Ma, Mark T. Hamann, Wei-Zhong Liu   +5 more
doaj   +1 more source

Organocatalytic Enantioselective Synthesis of Both Diastereomers of α-Hydroxyphosphinates [PDF]

, 2016
Racemic α-acylphosphinates and formylphosphinate hydrate were used directly as the substrates in a proline derivative-catalyzed cross aldol reaction with ketones. Because of the preexisting phosphorus stereogenic center, a mixture of two diastereomers of
Sandun Perera (1891984), Cong-Gui Zhao (2081026), Sampak Samanta (2317552)   +2 more
core   +3 more sources

Pure diastereomers of a tranylcypromine-based LSD1 inhibitor: enzyme selectivity and in-cell studies [PDF]

, 2015
The pure four diastereomers (11a-d) of trans-benzyl (1-((4-(2-aminocyclopropyl)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate hydrochloride 11, previously described by us as LSD1 inhibitor, were obtained by enantiospecific synthesis/chiral HPLC ...
Valente S, RUOPPOLO, Giovanni, Saverio Minucci, Oronza A. Botrugno, Mercurio C, Marrocco B, Varasi M, Antonello Mai, Paola Dessanti, Ciro Mercurio, MATTEVI, ANDREA, LABELLA, DONATELLA, MARROCCO, BIAGINA, Paola Vianello, Rodriguez V, Biagina Marrocco, Mario Varasi, Vianello P, Cirilli R, Sergio Valente, Saponara B, Botrugno OA, CIOSSANI, GIUSEPPE, Giovanni Ruoppolo, Veronica Rodriguez, Labella D, Dessanti P, VALENTE, Sergio, Mai A., Donatella Labella, Giuseppe Ciossani, Ruoppolo G, MAI, Antonello, Bruna Saponara, Roberto Cirilli, Andrea Mattevi, Minucci S   +36 more
core   +1 more source

Rotamers or Diastereomers? An Overlooked NMR Solution [PDF]

, 2016
The existence of rotamers in a solution of analyte complicates 1H NMR analysis, especially when the presence of diastereomers is also possible. Organic chemists have often responded to this problem by conducting variable-temperature (VT) NMR experiments,
Peter Grice (2078575), Dennis X. Hu (1630801), Steven V. Ley (532034)   +2 more
core   +1 more source

Preparative thin-layer and column chromatography of prostaglandins

Journal of Lipid Research, 1969
Analytical and preparative chromatographic methods for monounsaturated prostaglandins are described. The systems were developed specifically for separation of the various hydroxy epimers of prostaglandin E1 and F1 but also offer superior separations for ...
Niels H. Andersen
doaj   +1 more source

Asymmetric synthesis of α-alkylated carbonyl compounds and their biological application [PDF]

Delta Journal of Science, 2002
Creation of asymmetric centers is the fundamental basis of asymmetric synthesis as the resulting diastereomers or enantiomers are formed in unequal ratio.
Hamada Mandour, Adel Selim, Mariam Ezzat, Ahmed Noser   +3 more
doaj   +1 more source