Results 1 to 10 of about 6,377 (162)

Highly Diastereoselective Synthesis of Spiropyrazolones [PDF]

Molecules, 2015
We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
VÍCTOR Ceban, Temitope O Olomola, Marta Meazza   +2 more
exaly   +7 more sources

Highly selective and practical hydrogenation of functionalized (hetero)arenes [PDF]

Nature Communications
Arenes, and particularly heteroarenes are integral structural components of a variety of chemicals and represent a privileged class of bioactive compounds found in pharmaceuticals, agrochemicals and vitamins.
Ruiyang Qu, Soumyashree Jena, Lifeng Xiao, Hui Yang, Rongsheng Cai, Stephan Bartling, Hanan Atia, Ralf Jackstell, Robert Franke, Kathrin Junge, Haijun Jiao, Graham J. Hutchings, Matthias Beller   +12 more
doaj   +2 more sources

Diastereoselective synthesis of trans -2,3-dihydrofuro[3,2-c]coumarins by MgO nanoparticles under ultrasonic irradiation

Journal of Saudi Chemical Society, 2017
MgO nanoparticles have been used as an efficient catalyst for the diastereoselective preparation of trans-2-benzoyl-3-(aryl)-2H-furo[3,2-c]chromen-4(3H)-ones by the multi-component reaction of 2,4′-dibromoacetophenone, pyridine, benzaldehydes and 4 ...
Javad Safaei-Ghomi, Hossein Shahbazi-Alavi, Safura Zahedi   +2 more
exaly   +3 more sources

Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives

Molecules, 2021
Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the ...
Aitor Maestro, Xabier del Corte, Adrián López-Francés, Edorta Martínez de Marigorta, Francisco Palacios, Javier Vicario   +5 more
doaj   +1 more source

Phytophenol Dimerization Reaction: From Basic Rules to Diastereoselectivity and Beyond

Molecules, 2022
Phytophenol dimerization, which is a radical-mediated coupling reaction, plays a critical role in many fields, including lignin biosynthesis. To understand the reaction, 2,2-diphenyl-1-picrylhydrazyl radical was used to initiate a series of phytophenol ...
Shuqin Liu, Xican Li, Ban Chen, Xiaojian Ouyang, Yulu Xie, Dongfeng Chen   +5 more
doaj   +1 more source

Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors

Molecules, 2022
The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction ...
Amarender Manchoju, Renaud Zelli, Gang Wang, Carla Eymard, Adrian Oo, Mona Nemer, Michel Prévost, Baek Kim, Yvan Guindon   +8 more
doaj   +1 more source

Diastereoselective Synthesis of Benzoxanthenones

Chemistry – An Asian Journal, 2020
Abstract An oxidative catalytic vanadium(V) system was developed to access the naturally nonabundant diastereomers of carpanone from the corresponding alkenyl phenol monomer in one pot by tandem oxidation, oxidative coupling, and 4+2 cyclization. This system was applied to the synthesis of two other analogues of carpanone.
Erika Neuhaus, Marisa C Kozlowski
openaire   +3 more sources

Cyclic Nitriles:  Diastereoselective Alkylations [PDF]

The Journal of Organic Chemistry, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Fraser F, Fleming, Subrahmanyam, Gudipati, Zhiyu, Zhang, Wang, Liu, Omar W, Steward   +4 more
openaire   +2 more sources

Carbamate-directed benzylic lithiation for the diastereo- and enantioselective synthesis of diaryl ether atropisomers

Beilstein Journal of Organic Chemistry, 2011
Diaryl ethers carrying carbamoyloxymethyl groups may be desymmetrised enantio- and diastereoselectively by the use of the sec-BuLi–(−)-sparteine complex in diethyl ether.
Abigail Page, Jonathan Clayden
doaj   +1 more source

Diastereoselective Spiroannulation of Phenolic Substrates: Advances Towards the Asymmetric Formation of the Manumycin m-C7N Core Skeleton

Molecules, 2007
The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new ...
Thomas W. Scully, Jolene S. Kwasnitza, Randy R. Spaetzel, Guy L. Plourde   +3 more
doaj   +1 more source