Results 1 to 10 of about 27,841 (247)
Highly Diastereoselective Synthesis of Spiropyrazolones [PDF]
Molecules, 2015 We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
Temitope O Olomola +2 more
exaly +7 more sources
Diastereoselective synthesis of tetrahydroisoquinolines through the Pd-catalyzed post-Ugi transformations [PDF]
RSC AdvancesWe present a diastereoselective approach to sp3-enriched tetrahydroisoquinolines from Ugi-derived propargylamides through a sequence combining Pd-catalyzed reductive Heck cyclization with heterogeneous double-bond hydrogenation.
Manzoor Zaman +13 more
doaj +2 more sources
Highly selective and practical hydrogenation of functionalized (hetero)arenes [PDF]
Nature CommunicationsArenes, and particularly heteroarenes are integral structural components of a variety of chemicals and represent a privileged class of bioactive compounds found in pharmaceuticals, agrochemicals and vitamins.
Ruiyang Qu +12 more
doaj +2 more sources
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives
Molecules, 2021 Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the ...
Aitor Maestro +5 more
doaj +1 more source
Phytophenol Dimerization Reaction: From Basic Rules to Diastereoselectivity and Beyond
Molecules, 2022 Phytophenol dimerization, which is a radical-mediated coupling reaction, plays a critical role in many fields, including lignin biosynthesis. To understand the reaction, 2,2-diphenyl-1-picrylhydrazyl radical was used to initiate a series of phytophenol ...
Shuqin Liu +5 more
doaj +1 more source
Molecules, 2022 The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction ...
Amarender Manchoju +8 more
doaj +1 more source
Journal of Saudi Chemical Society, 2017 MgO nanoparticles have been used as an efficient catalyst for the diastereoselective preparation of trans-2-benzoyl-3-(aryl)-2H-furo[3,2-c]chromen-4(3H)-ones by the multi-component reaction of 2,4â²-dibromoacetophenone, pyridine, benzaldehydes and 4 ...
Javad Safaei-Ghomi +3 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2011 Diaryl ethers carrying carbamoyloxymethyl groups may be desymmetrised enantio- and diastereoselectively by the use of the sec-BuLi–(−)-sparteine complex in diethyl ether.
Abigail Page, Jonathan Clayden
doaj +1 more source
Molecules, 2007 The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new ...
Thomas W. Scully +3 more
doaj +1 more source
Diastereoselective Synthesis of 5-Hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one
Molecules, 2013 A short five steps synthesis of the title compound from vanillin is described. The racemic spiroether 7 was obtained in 61% yield and in >99% diastereomeric excess (by 1H-NMR) from the corresponding phenolic derivative 3 by oxidation with lead (IV)
Thomas W. Scully, Guy L. Plourde
doaj +1 more source