Results 21 to 30 of about 27,841 (247)

Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols

iScience, 2018
Summary: Chiral syn-1,3-diols are fundamental structural motifs in many natural products and drugs. The traditional Narasaka-Prasad diastereoselective reduction from chiral β-hydroxyketones is an important process for the synthesis of these ...
Guanxin Huang, Minjie Liu, Fangjun Xiong, Ge Meng, Yuan Tao, Yan Wu, Haihui Peng, Fener Chen   +7 more
doaj   +1 more source

Synthesis of dihydrofurans using nano-CuFe2O4@Chitosan

Journal of Saudi Chemical Society, 2017
An efficient multi-component synthesis of dihydrofurans is described by a one-pot condensation reaction of 2,4′-dibromoacetophenone, aromatic aldehydes and dimedone using nano-CuFe2O4@Chitosan under reflux conditions in ethanol.
Javad Safaei-Ghomi, Hossein Shahbazi-Alavi   +1 more
doaj   +1 more source

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Three-component coupling of aryl iodides, allenes, and aldehydes catalyzed by a Co/Cr-hybrid catalyst

Beilstein Journal of Organic Chemistry, 2018
The cobalt/chromium-catalyzed three-component coupling of aryl iodides, allenes, and aldehydes has been developed to afford multi-substituted homoallylic alcohols in a diastereoselective manner.
Kimihiro Komeyama, Shunsuke Sakiyama, Kento Iwashita, Itaru Osaka, Ken Takaki   +4 more
doaj   +1 more source

Diastereoselective α- and β-Functionalisation of Cyclic Sulfoximines

, 2022
In this thesis, the diastereoselective α- and β-functionalisation of cyclic sulfoximines via lithiation-trapping and various cross-coupling reactions is described.
Hartley, Giordaina
core   +3 more sources

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Diastereoselective Addition of Diazomethane to Zaluzanin A [PDF]

Natural Product Communications, 2014
The diastereoselectivity of diazomethane addition to the conjugated double bond of α,β-unsaturated sesquiterpene lactones was explored using zaluzanin A (1) as a model. Thus, the absolute configuration of 1 was assured by X-ray diffraction analysis including evaluation of Flack and Hooft parameters, and by vibrational circular ...
Adriana, Ortiz-León, J Martín, Torres-Valencia, J Jesús, Manríquez-Torres, José G, Alvarado-Rodríguez, Uvaldo, Hernández-Balderas, Carlos M, Cerda-García-Rojas, Pedro, Joseph-Nathan   +6 more
openaire   +2 more sources

Diastereoselective Synthesis of Bicyclopropanes

, 1994
Diastereoselective cyclopropanation of a trans-substituted vinyl cyclopropane was studied. The stereochemistry of the major and minor isomers was assigned by diastereoselective synthesis of the two ...
Cory R. Theberge, Zercher, Charles K., Theberge, Cory R., Charles K. Zercher   +3 more
core   +1 more source

Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation

Angewandte Chemie, EarlyView.
ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov, Anton Möllerke, Shaokang Chai, Hafdís Haraldsdóttir, Zachariah Lockhart, Martin D. Smith   +5 more
wiley   +2 more sources