Results 1 to 10 of about 8,340 (167)

Photocatalytic Stereoselective Editing of Alkynes to 3D Molecules via Hydrogen Atom Transfer-Mediated Dynamic Epimerization [PDF]

Nature Communications
Three-dimensional molecules have drawn tremendous attention due to their pivotal roles in drug discovery as saturated bioisosteres of benzenoids. The direct construction of these scaffolds from simple and readily available one-dimensional building blocks
Zhenyu Gu, Tianqin Zeng, Zheliang Yuan, Hanliang Zheng, Gangguo Zhu   +4 more
doaj   +2 more sources

Iodine-promoted oxidative homocoupling of methyl 2-arylacetates under equilibrium conditions using potassium tert-butoxide as a base

Results in Chemistry, 2022
Iodine-promoted dimerization of enolates of methyl 2-arylacetates generated with tBuOK under equilibrium conditions are reported. The oxidative homocoupling reaction furnishes a mixture of dl and meso dimers in moderate to good yields and ...
Ahmed Y. Nuriye, Joseph Barr
doaj   +1 more source

Regio- and Diastereoselective Vicinal Aminobromination of Electron Deficient Olefins via Phosphorus-Based GAP Protocol

Frontiers in Chemistry, 2021
Chemical synthesis based on Group-Assisted Purification chemistry (GAP) has been prolifically used as a powerful, greener and ecofriendly tool so far. Herein, we report hypervalent iodine (III) mediated regio- and diastereoselective aminobromination of ...
Anis Ur Rahman, Nighat Zarshad, Iltaf Khan, Faisal Faiz, Guigen Li, Guigen Li, Asad Ali   +6 more
doaj   +1 more source

An Approach toward 17-Arylsubstituted Marginatafuran-Type Isospongian Diterpenoids via a Palladium-Catalyzed Heck–Suzuki Cascade Reaction of 16-Bromolambertianic Acid

Molecules, 2022
Isospongian diterpenes are a small but growing family of natural tetracyclic secondary metabolites isolated from marine organisms, primarily sponges and nudibranchs.
Yurii V. Kharitonov, Elvira E. Shults
doaj   +1 more source

Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction

SynOpen, 2023
Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range
Yana Sakhno, Oleksandr Radchenko, Vyacheslav Saraev, Yuliia Shliapkina, Mariia Kaidash, Mariia Shyshkina, Svitlana Shishkina, Vladimir Musatov, Sergey Desenko, Valentyn Chebanov   +9 more
doaj   +1 more source

Highly Diastereoselective Construction of Carbon– Heteroatom Quaternary Stereogenic Centers in the Synthesis of Analogs of Bioactive Compounds: From Monofluorinated Epoxyalkylphosphonates to α-Fluoro-, β-, or γ-Amino Alcohol Derivatives of Alkylphosphonates

Frontiers in Chemistry, 2021
The synthesis of the stable surrogates of an important amino acid (R)-4-amino-3-hydroxybutyric acid (GABOB) such as substituted hydroxy aminophosphonic acids bearing a quaternary stereogenic center is presented.
Magdalena Rapp, Klaudia Margas-Musielak, Patrycja Kaczmarek, Agnieszka Witkowska, Tomasz Cytlak, Tomasz Cytlak, Tomasz Siodła, Henryk Koroniak   +7 more
doaj   +1 more source

Highly Diastereoselective Synthesis of Spiropyrazolones [PDF]

Molecules, 2015
We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
Ceban, Victor, Olomola, Temitope, Meazza, Marta, Rios Torres, Ramon   +3 more
openaire   +5 more sources

Diastereoselective Synthesis of Benzoxanthenones

Chemistry – An Asian Journal, 2020
Abstract An oxidative catalytic vanadium(V) system was developed to access the naturally nonabundant diastereomers of carpanone from the corresponding alkenyl phenol monomer in one pot by tandem oxidation, oxidative coupling, and 4+2 cyclization. This system was applied to the synthesis of two other analogues of carpanone.
Erika Neuhaus, Marisa C Kozlowski
openaire   +3 more sources

Cyclic Nitriles:  Diastereoselective Alkylations [PDF]

The Journal of Organic Chemistry, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Fraser F, Fleming, Subrahmanyam, Gudipati, Zhiyu, Zhang, Wang, Liu, Omar W, Steward   +4 more
openaire   +2 more sources

Studies on the Synthesis of DMAP Derivatives by Diastereoselective Ugi Reactions

Molecules, 2011
Diastereoselective Ugi reactions of DMAP-based aldehydes with α-amino acids and tert-butyl isocyanide were examined. The reactions of 4-(dimethylamino)-2-pyridine-carboxaldehyde with various α-amino acids afforded 2-substituted DMAP derivatives with low ...
Koichi Mitsudo, Seiji Suga, Hiroki Mandai, Shunsuke Irie   +3 more
doaj   +1 more source