Results 31 to 40 of about 16,892 (273)

Diastereoselectivity in the Paternò-Büchi reaction on furan derivatives

, 2004
The reaction of benzoin, 4,40-dimethoxybenzoin and benzoin ethyl ether with furan gave the corresponding adduct with high diastereoselectivity (71–100%).
RACIOPPI, Rocco, EMANUELE L., D'AURIA, Maurizio   +2 more
core   +1 more source

Novel Polycondensed Partly Saturated β-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of their In Vitro Antiproliferative Effects

Molecules, 2020
Use of a Pictet-Spengler reaction of tryptamine and l-tryptophan methyl ester and subsequent reduction of the nitro group followed by further cyclocondensation with aryl aldehydes and formyl–substituted carboxylic acids, including ferrocene-based ...
Kinga Judit Fodor, Dániel Hutai, Tamás Jernei, Angéla Takács, Zsófia Szász, Máté Sulyok-Eiler, Veronika Harmat, Rita Oláh Szabó, Gitta Schlosser, Ferenc Hudecz, László Kőhidai, Antal Csámpai   +11 more
doaj   +1 more source

Probing the mechanism of diastereoselectivity of pseudoephedrine amide enolate alkylations

, 2011
Pseudoephedrine was first used by Myers as a practical auxiliary for the asymmetric alkylation of amide enolates. The pseudoephedrine amide enolate intermediate is proposed by Myers et al.
Lory, Caroline
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Diastereoselectivity in the Staudinger reaction of pentafluorosulfanylaldimines and ketimines

Beilstein Journal of Organic Chemistry, 2013
β-Lactams were diastereoselectively formed by the reaction of SF5-containing aldimines, or an SF5-containing ketimine, with benzyloxyketene in a conrotatory ring closure process. Imine formation and cyclization were possible in spite of the acidification
Alexander Penger, Cortney N. von Hahmann, Alexander S. Filatov, John T. Welch   +3 more
doaj   +1 more source

TDAE Strategy for the Synthesis of 2,3-Diaryl N-Tosylaziridines

Molecules, 2013
We report herein an original and rapid synthesis of 2,3-diaryl N-tosylaziridines by TDAE strategy starting from ortho- or para-nitro(dichloromethyl)benzene derivatives and N-tosylimines. A mixture of cis/trans isomers was isolated from 1-(dichloromethyl)-
Thierry Terme, Cédric Spitz, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

(1R/S,7aS/R)-1-Benzyl-1-[2,8-bis(trifluoromethyl)quinolin-4-yl]-hexahydro-oxazolo[3,4-a]pyridin-3-one

Molbank, 2023
An unexpected diastereoselective C-alkylation of a mefloquine derivative in up to 57% yield was the result of an attempted Williamson etherification of Boc-mefloquine.
Dawid J. Kucharski, Przemysław J. Boratyński   +1 more
doaj   +1 more source

Diastereoselective Intramolecular Cyanoamidation with Alkenes [PDF]

European Journal of Organic Chemistry, 2016
Reported herein is a diastereoselective intramolecular alkene cyanoamidation, wherein high d.r. values are imparted by chiral directing groups. Lactams with an α‐all‐carbon quaternary stereocenter are readily synthesized, which may enable access to structures frequently found in biologically active molecules and natural products.
Ashley M. Dreis, Sadie C. Otte, Matthew S. Eastwood, Elizabeth R. Alonzi, Jason T. Brethorst, Christopher J. Douglas   +5 more
openaire   +2 more sources

Diastereoselectivity of Azido-Ugi Reaction with Secondary Amines. Stereoselective Synthesis of Tetrazole Derivatives

, 2020
The diastereoselectivity of azido-Ugi reaction with cyclic amines was investigated. It was found that the reaction with α-substituted five- to seven-membered cyclic amines proceeds very efficiently to provide high control of diastereoselectivity (≤100 ...
Khrustalev V.N., Nenajdenko V.G., Zarezin D.P.   +2 more
core   +2 more sources

A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline

Beilstein Journal of Organic Chemistry, 2017
A series of 15 benzene-fused hexahydropyrrolo[1,2-b]isoquinolonic acids with substantial degree of steric encumbrance has been prepared via a novel variant of the Castagnoli–Cushman reaction of homophthalic anhydride (HPA) and various indolenines.
Olga Bakulina, Alexander Ivanov, Vitalii Suslonov, Dmitry Dar’in, Mikhail Krasavin   +4 more
doaj   +1 more source