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Multicomponent Reactions for the Synthesis of Active Pharmaceutical Ingredients [PDF]
Pharmaceuticals, 2022 Multicomponent reactions 9i.e., those that engage three or more starting materials to form a product that contains significant fragments of all of them), have been widely employed in the construction of compound libraries, especially in the context of ...
Ángel Cores +3 more
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Multicomponent Reactions [PDF]
Molecules, 2019 Multicomponent Reactions appear to be ideal for any form of synthesis, because of their numerous advantages in terms of sustainability and selectivity in building up complex molecular architectures, with high molecular diversity.
Cristina Cimarelli
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Formaldehyde surrogates in multicomponent reactions [PDF]
Beilstein Journal of Organic ChemistryFormaldehyde emerges as a cornerstone in multicomponent reactions, mainly prized for its robust reactivity. Yet, alongside these beneficial traits, this highly reactive C1-building block raises concerns, primarily regarding its toxicity.
Cecilia I. Attorresi +2 more
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Multicomponent Reactions: "Kinderleicht". [PDF]
J Chem Educ, 2020 A demonstration experiment of the synthesis of a novel tetrazole derivative via a multicomponent reaction (Ugi tetrazole four component reaction, UT-4CR) bearing a luminol moiety and a subsequent exploitation of its chemiluminescent properties is ...
Neochoritis CG +3 more
europepmc +5 more sources
Multicomponent reactions IV [PDF]
Beilstein Journal of Organic ChemistryThomas J. J. Müller +1 more
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Multicomponent reactions II [PDF]
Beilstein Journal of Organic Chemistry, 2014 The concept of multicomponent reactions (MCR) [1] has been around in organic chemistry since the very early days. Indeed, the first example known in literature, the Strecker synthesis of α-aminonitriles [2], has been developed into an industrial process for the production of methionine in an annual scale of several hundreds of thousand tons per year ...
Thomas J. J. Müller
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Multicomponent Reactions between Heteroatom Compounds and Unsaturated Compounds in Radical Reactions [PDF]
Molecules, 2023 In this mini-review, we present our concepts for designing multicomponent reactions with reference to a series of sequential radical reactions that we have developed.
Akiya Ogawa, Yuki Yamamoto
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Pseudo-multicomponent reactions. [PDF]
RSC Adv, 2023 Pseudo-MCRs are domino-type one-pot processes that involve combinations of at least three reactants (similarly to normal MCRs) but in which one of them is stoichiometrically duplicated (or more) and hence takes part into two reaction steps (or more).
Flores-Reyes JC +4 more
europepmc +3 more sources
Accelerating Drug Discovery: Synthesis of Complex Chemotypes via Multicomponent Reactions. [PDF]
ACS Med Chem Lett, 2023 The generation of multiple bonds in one reaction step has attracted massive interest in drug discovery and development. Multicomponent reactions (MCRs) offer the advantage of combining three or more reagents in a one-pot fashion to effectively yield a ...
Buskes MJ +4 more
europepmc +2 more sources
Tetrazoles via Multicomponent Reactions [PDF]
Chemical Reviews, 2019 Tetrazole derivatives are a prime class of heterocycles, very important to medicinal chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide moieties but also to their metabolic stability and other beneficial ...
Constantinos G. Neochoritis +2 more
semanticscholar +4 more sources