The 100 facets of the Passerini reaction. [PDF]
Chem Sci, 2021 This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini three component reaction. After being nearly neglected for many years, now this reaction has become quite popular, thanks to the achievements of the last 30 ...
Banfi L +4 more
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Exploring Phthalimide as the Acid Component in the Passerini Reaction. [PDF]
Org LettMulticomponent reactions, particularly the Passerini reaction, serve as efficient tools for the synthesis of druglike molecules and the creation of compound libraries.
Li J, Zheng Q, Dömling A.
europepmc +7 more sources
Synthesis of Polyoxygenated Heterocycles by Diastereoselective Functionalization of a Bio-Based Chiral Aldehyde Exploiting the Passerini Reaction [PDF]
Molecules, 2020 A chiral bio-based building block, prepared by the lipase-mediated desymmetrization of an erythritol derivative, was further functionalized and then submitted to stereoselective Passerini reactions, allowing the synthesis of a small library of new ...
Gabriella Vitali Forconesi +5 more
doaj +5 more sources
Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction? [PDF]
J Org Chem, 2023 This year represents the 100th anniversary of the discovery of the Passerini three-component reaction. The related Ugi four-compound reaction was discovered 37 years after the Passerini reaction.
Dömling A.
europepmc +5 more sources
Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols. [PDF]
Org Lett, 2018 A new Passerini-type reaction in which hexafluoroisopropanol functions as the acid component is reported. The reaction tolerates a broad range of isocyanides and aldehydes, and the formed imidates can be reduced toward β-amino alcohols under mild and ...
Saya JM +6 more
europepmc +5 more sources
C-Linked Glycomimetic Libraries Accessed by the Passerini Reaction. [PDF]
Int J Mol Sci, 2019 Carbohydrates and their conjugates are the most abundant natural products, with diverse and highly important biological roles. Synthetic glycoconjugates are versatile tools used to probe biological systems and interfere with them.
Vlahoviček-Kahlina K +2 more
europepmc +8 more sources
Silica gel-immobilised chiral 1,2-benzenedisulfonimide: a Brønsted acid heterogeneous catalyst for enantioselective multicomponent Passerini reaction. [PDF]
RSC Adv, 2021 A chiral heterogeneous catalyst derivative of (−)-4,5-dimethyl-3,6-bis(1-naphthyl)-1,2-benzenedisulfonimide is proven here to be efficient in a three-component asymmetric Passerini protocol, carried out in a deep eutectic solvent. Reaction conditions are
Antenucci A, Marra F, Dughera S.
europepmc +2 more sources
Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery. [PDF]
Proc Natl Acad Sci U S ASignificance Effective delivery strategies are vital for message RNA (mRNA) vaccines and therapeutics, with lipid nanoparticles (LNPs) being forefront. Developing ionizable lipids, a key LNP component, traditionally involves complex, multistep synthesis ...
Xu Y +8 more
europepmc +2 more sources
Mystery of the Passerini Reaction for the Synthesis of the Antimicrobial Peptidomimetics against Nosocomial Pathogenic Bacteria. [PDF]
Int J Mol SciThe first example of applying salicylaldehyde derivatives, as well as coumarin with the formyl group at the C8 position in its structure, as carbonyl partners in a three-component Passerini reaction, is presented.
Wavhal DS +6 more
europepmc +2 more sources
Synthesis of Triterpenoid-Derived α-Acyloxycarboxamides via Passerini Reaction
Chemistry Proceedings, 2021 Herein we describe the synthesis of a small series of α-acyloxycarboxamides via a facile and efficient one-pot procedure, employing a plant-derived triterpenoid as carboxylic acid component.
Fidel Rodríguez-López +2 more
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