The 100 facets of the Passerini reaction. [PDF]
Chem Sci, 2021 This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini three component reaction.
Banfi L +4 more
europepmc +4 more sources
Synthesis of Polyoxygenated Heterocycles by Diastereoselective Functionalization of a Bio-Based Chiral Aldehyde Exploiting the Passerini Reaction [PDF]
Molecules, 2020 A chiral bio-based building block, prepared by the lipase-mediated desymmetrization of an erythritol derivative, was further functionalized and then submitted to stereoselective Passerini reactions, allowing the synthesis of a small library of new ...
Gabriella Vitali Forconesi +5 more
doaj +2 more sources
Stereochemical control of the Passerini reaction. [PDF]
Org Lett, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Andreana PR, Liu CC, Schreiber SL.
europepmc +5 more sources
Exploring Phthalimide as the Acid Component in the Passerini Reaction. [PDF]
Org LettMulticomponent reactions, particularly the Passerini reaction, serve as efficient tools for the synthesis of druglike molecules and the creation of compound libraries. Despite the effectiveness of the Passerini reaction, the limited alternatives to the crucial carboxylic acid component pose a structural constraint.
Li J, Zheng Q, Dömling A.
europepmc +3 more sources
Creating unimolecular multivalent diversity in protein conjugates via the Passerini multicomponent bioconjugation with isocyanoproteins [PDF]
Communications ChemistryThe ability to conjugate multiple molecules to a protein is of great interest for pharmaceutical and vaccine development, especially if this can be achieved in a one-pot procedure.
Ana R. Humpierre +11 more
doaj +2 more sources
C-Linked Glycomimetic Libraries Accessed by the Passerini Reaction. [PDF]
Int J Mol Sci, 2019 Carbohydrates and their conjugates are the most abundant natural products, with diverse and highly important biological roles. Synthetic glycoconjugates are versatile tools used to probe biological systems and interfere with them. In an endeavor to provide an efficient route to glycomimetics comprising structurally diverse carbohydrate units, we ...
Vlahoviček-Kahlina K +2 more
europepmc +7 more sources
Accessing Promising Passerini Adducts in Anticancer Drug Design [PDF]
MoleculesThe 3-component Passerini reaction (3CPR), discovered little more than 100 years ago, has been demonstrated in the last few decades to be a valuable tool for accessing structural diversity and complexity, essential topics to consider in drug discovery ...
Ana Margarida Janeiro +3 more
doaj +2 more sources
Innovative synthesis of drug-like molecules using tetrazole as core building blocks [PDF]
Beilstein Journal of Organic ChemistryTetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like characteristics of various molecules.
Jingyao Li +3 more
doaj +2 more sources
Total Synthesis of 4-epi-Bengamide E [PDF]
MoleculesBengamide E is a bioactive natural product that was isolated from Jaspidae sponges by Crews and co-workers in 1989. It displays a wide range of biological activities, including antitumor, antibiotic, and anthelmintic properties.
Gabriella Vitali Forconesi +8 more
doaj +2 more sources
Green and three-component synthesis of 2-cyclohexylamino-2-oxo-1-arylethyl/alkyl thiophene-3-carboxylates in aqueous medium [PDF]
شیمی کاربردی روز, 2021 From the Passerini three-component reaction between cyclohexyl isocyanide, thiophene-2-carboxylic acid and aryl/alkyl aldehydes, some new compounds of 2-cyclohexylamino-2-oxo-1-arylethyl/alkyl thiophene-3-carboxylates have been synthesized in 30-45 min ...
sima mosavi niaraki +3 more
doaj +1 more source