Synthesis of Various N ‐heterocycles Using the Ugi Four‐Center Three‐Component Reaction
ChemistrySelect, 2019Leyla Mohammadkhani +2 more
exaly
α-Ketoglutaric acid in Ugi reactions and Ugi/aza-Wittig tandem reactions [PDF]
Beilstein Journal of Organic ChemistryA small library of bis- and tetraamides was synthesized by the Ugi reaction with α-ketoglutaric acid, tert-butyl isocyanide, aromatic aldehydes, and aromatic amines.
Vladyslav O. Honcharov +6 more
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N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides [PDF]
Organic Letters, 2017 The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides.
Ajay L Chandgude, Alexander Domling
exaly +4 more sources
Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions [PDF]
Beilstein Journal of Organic Chemistry, 2016 Herein we describe a versatile approach for the synthesis of acylhydrazino-peptomers, a new class of peptidomimetics. The key idea in this approach is based on a simple route using a one-pot hydrazino-Ugi four-component reaction followed by a ...
Angélica de Fátima S. Barreto +2 more
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Hydrazine in the Ugi Tetrazole Reaction [PDF]
Synthesis, 2016 We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles. The reaction is very versatile and good to high yielding. A one-pot, two-step procedure is given.
Patil +5 more
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Catalytic Three‐Component Ugi Reaction [PDF]
Angewandte Chemie International Edition, 2008 Perfect atom economy characterizes a novel catalytic three‐component Ugi reaction (see example). Different α‐amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst. The products will be useful for the synthesis of α‐amino acid derivatives and in diversity‐oriented
Pan, S., List, B.
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Harnessing unprotected deactivated amines and arylglyoxals in the Ugi reaction for the synthesis of fused complex nitrogen heterocycles [PDF]
Beilstein Journal of Organic ChemistryPiperazines and diazepines are examples of nitrogen heterocycles present in many marketed drugs highlighting their importance in the discovery of novel bioactive compounds.
Javier Gómez-Ayuso +5 more
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Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins [PDF]
Beilstein Journal of Organic Chemistry, 2018 A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary ...
Robby Vroemans +7 more
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Novel postmodifications of the Ugi reaction [PDF]
, 2016 In this thesis several novel postmodifiactions of regular Ugi-4CR products have been examined. Their scope and limitations were tested both by permutating the required functionalities around the Ugi scaffold and by synthesizing compound libraries for successful permutations. The following reactions were examined: 1.
Welsch, Sebastian
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Diastereoselective Ugi reaction for the synthesis of unnatural amino esters
Orbital: The Electronic Journal of Chemistry, 2012 Multicomponent Reactions (MCR) are useful reactions to obtain complex products by the simple mixture of 3 or more reactants. The classic Ugi reaction (4-UCR) involves a mixture of an amine, aldehyde, isocyanide and a carboxylic acid, giving peptoides as ...
Rafael Oliveira Rocha +4 more
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