Results 41 to 50 of about 2,043,921 (203)
Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts [PDF]
Frontiers in Chemistry, 2019 We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate in the presence of palladium catalysts.
Alaa Zidan +5 more
openaire +4 more sources
SynOpen, 2018 Biologically attractive azaspiro[4.5]trienones have been prepared via Ugi four-component reaction (Ugi-4CR) followed by bromine-mediated ipso-cyclization.
Saeed Balalaie +5 more
doaj +1 more source
Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence
Molecules, 2021 Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego +2 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2014 An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed.
Giordano Lesma +4 more
doaj +1 more source
, 2016 The Ugi coupling reaction involves the combination of isocyanide (a), aldehyde (b), amine (c) and carboxylic acid (d) components in a single reaction step to give an α-aminoacyl amide product, as exemplified above for the preparation of AZ126.
Darren S. Heeke (3220149) +13 more
core +1 more source
The Catalytic Enantioselective Ugi Four‐Component Reactions [PDF]
Angewandte Chemie International Edition, 2018 Finally stereoselective: Enantioselective variations have been developed for many multicomponent reactions; however, it has been missing for the Ugi four-component reaction. This has now changed with the discovery of an efficient catalytic enantioselective variant for the four-component reaction of isocyanides, primary amines, aldehydes or ketones, and
Shabnam Shaabani, Alexander Dömling
openaire +2 more sources
The Ugi reaction in polymer chemistry: syntheses, applications and perspectives
, 2015 The Ugi reaction, one of the most famous multicomponent reactions, has recently been introduced into polymer chemistry as a novel, efficient and useful tool to prepare multifunctional polymers.
Wei, Yen +4 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2019 The synthesis of a novel category of pseudo-peptides via intramolecular Ugi reaction of levulinic acid (4-oxopentanoic acid), aromatic and aliphatic amines, and amino acid-based isocyanides is reported.
Maryam Khalesi +2 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon +9 more
wiley +1 more source
Substituent Effects in Ugi–Smiles Reactions
The Journal of Physical Chemistry A, 2013 In a recent communication, we described the mechanism of the well-known Ugi-type reactions with a model system (J. Org. Chem. 2012, 77, 1361-1366). Herein, focusing on the Ugi-Smiles coupling, we study the effects of each of the four reactants on the energy profile to further explain the experimental results.
Chéron, Nicolas +4 more
openaire +3 more sources