Results 41 to 50 of about 2,155,266 (206)

Diastereoselective Ugi reaction for the synthesis of unnatural amino esters

Orbital: The Electronic Journal of Chemistry, 2012
Multicomponent Reactions (MCR) are useful reactions to obtain complex products by the simple mixture of 3 or more reactants. The classic Ugi reaction (4-UCR) involves a mixture of an amine, aldehyde, isocyanide and a carboxylic acid, giving peptoides as ...
Rafael Oliveira Rocha, Milenna Milhomem Sena, Gecimar Oliveira Gomes, Carlos Kleber Z. Andrade, Márcio Weber Paixão   +4 more
doaj   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

New tandem Ugi/intramolecular Diels–Alder reaction based on vinylfuran and 1,3-butadienylfuran derivatives

Beilstein Journal of Organic Chemistry
A new tandem sequence involving the Ugi reaction and Diels–Alder [4 + 2] cycloaddition based on vinylfuran and 1,3-butadienylfuran derivatives was designed and studied.
Yuriy I. Horak, Roman Z. Lytvyn, Andrii R. Vakhula, Yuriy V. Homza, Nazariy T. Pokhodylo, Mykola D. Obushak   +5 more
doaj   +1 more source

Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides

Beilstein Journal of Organic Chemistry, 2019
The synthesis of a novel category of pseudo-peptides via intramolecular Ugi reaction of levulinic acid (4-oxopentanoic acid), aromatic and aliphatic amines, and amino acid-based isocyanides is reported.
Maryam Khalesi, Azim Ziyaei Halimehjani, Jürgen Martens   +2 more
doaj   +1 more source

Peptide array functionalization via the Ugi four-component reaction

, 2017
The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arraysviapost-synthetic side-chain modification as well as integration of an Ugi unit into a growing peptide chain.
M. A. R. Meier, Mattes, D. S., Breitling, F., Ridder, B., F. Breitling, D. S. Mattes, Meier, M. A. R., Nesterov-Mueller, A., A. Nesterov-Mueller, B. Ridder   +9 more
core   +1 more source

Substituent Effects in Ugi–Smiles Reactions

The Journal of Physical Chemistry A, 2013
In a recent communication, we described the mechanism of the well-known Ugi-type reactions with a model system (J. Org. Chem. 2012, 77, 1361-1366). Herein, focusing on the Ugi-Smiles coupling, we study the effects of each of the four reactants on the energy profile to further explain the experimental results.
Chéron, Nicolas, Ramozzi, Romain, El Kaim, Laurent, Grimaud, Laurence, Fleurat-Lessard, Paul   +4 more
openaire   +3 more sources

Ugi-Functionalized Magnetic Carbon Quantum Dots: an Efficient and Environmentally Friendly Catalyst for the Synthesis of 1,4-Dihydropyridines

Journal of Science: Advanced Materials and Devices
This research presents the synthesis of Ugi-modified magnetic carbon quantum dots (MCQD-AP-Ugi) via a one-pot process to improve functionality. For the first time, the Ugi reaction was utilized to modify the surface of carbon quantum dots (CQDs), thereby
Faezeh Montazeri, Robabeh Baharfar, Behrooz Maleki   +2 more
doaj   +1 more source

One‐Pot Synthesis of a Small Synthetic Ligand for Antibody Purification

Biotechnology and Bioengineering, EarlyView.
One‐pot liquid‐phase synthesis of the synthetic ligand B1Al2A2 enables controllable ligand density and efficient capture of IgG and IgY with high recovery and purity, streamlining small‐ligand affinity purification workflows. ABSTRACT The development of synthetic affinity ligands offers a cost‐effective alternative to traditional biological ligands ...
Carolina Mota Natal, Catarina Domingos, André Nascimento, José Mendes, Afonso B. Ruiz, Ana Margarida Gonçalves Carvalho Dias, Luisa M. Ferreira, Cristina Peixoto, Ana Cecília Afonso Roque   +8 more
wiley   +1 more source

Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients [PDF]

The Korean Journal of Internal Medicine
Background/Aims Cytomegalovirus (CMV) disease in the upper gastrointestinal (UGI) tract frequently occurs in immunocompromised patients. However, data regarding UGI CMV disease in non-transplant patients compared with those in transplant recipients are ...
Yuri Kim, Do Hoon Kim, Myeongsook Seo, Hee Kyong Na, Kee Wook Jung, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung   +10 more
doaj   +1 more source

Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains

Molecules, 2022
An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields.
Parul Sahrawat, Paweł Kowalczyk, Dominik Koszelewski, Mateusz Szymczak, Karol Kramkowski, Aleksandra Wypych, Ryszard Ostaszewski   +6 more
doaj   +1 more source