Designing Peptidomimetics [PDF]
Current Topics in Medicinal Chemistry, 2018 The concept of a peptidomimetic was coined about forty years ago. Since then, enormous effort and interest have been devoted to mimic the properties of peptides with small molecules or pseudopeptides. The present report aims to review different approaches described in the past to succeed in this goal.
Juan J Perez
exaly +6 more sources
Peptidomimetics Therapeutics for Retinal Disease
Biomolecules, 2021 Ocular disorders originating in the retina can result in a partial or total loss of vision, making drug delivery to the retina of vital importance.
Alexander Bassuk, Young Joo Sun
exaly +4 more sources
Cholinesterases inhibition profiles with Ugi-derived peptidemimetics: A combined experimental and computational study [PDF]
ADMET and DMPKBackground and purpose: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are crucial enzymes implicated in various neurological disorders, including Alzheimer’s disease.
Alma Ramić +9 more
doaj +2 more sources
Peptidomimetics in cancer targeting
Molecular Medicine, 2022 The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression.
Mohammad Mahmoudi Gomari +9 more
doaj +3 more sources
Peptides and Peptidomimetics as Immunomodulators [PDF]
Immunotherapy, 2014 Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the conformational aspects of peptides,
Ameya S, Gokhale +1 more
exaly +3 more sources
Therapeutic potential of peptidomimetics of suppressors of cytokine signaling (SOCS) proteins in rheumatic disorders [PDF]
Frontiers in MedicineDysregulation of the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway is increasingly recognized as a central molecular hallmark in the pathogenesis of multiple rheumatic diseases. Suppressors of cytokine signaling (SOCS)
Alessia Cugudda, Daniela Marasco
doaj +2 more sources
Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs
Molecules, 2017 The rapid emergence of multidrug-resistant pathogens has evolved into a global health problem as current treatment options are failing for infections caused by pan-resistant bacteria.
Natalia Molchanova +2 more
exaly +3 more sources
Antimicrobial Cyclic Peptidomimetics. [PDF]
Macromol Rapid CommunABSTRACT Antimicrobial resistance is a critical global healthcare issue that urgently needs the development of new antimicrobial agents. Herein, we developed new and discrete cationic amphipathic cyclic peptidomimetics as potential antimicrobial agents to combat multidrug‐resistant bacteria. These cyclic oligomers
Luo H, Wong EHH.
europepmc +3 more sources
Evaluation of the Synergistic Activity of Antimicrobial Peptidomimetics or Colistin Sulphate with Conventional Antifungals Against Yeasts of Medical Importance [PDF]
Journal of FungiWith rising multidrug-resistant yeast pathogens, conventional antifungals are becoming less effective, urging the need for adjuvants that enhance their activity at lower doses.
Shyam Kumar Mishra +12 more
doaj +2 more sources
Inhibition of Human Coronavirus 229E by Lactoferrin-Derived Peptidomimetics [PDF]
PharmaceuticsBackground/Objectives: Viral respiratory infections have a significant impact on global health and the economy. While vaccines are effective in preventing infection, they might not be available or sufficient when used alone and must be complemented by ...
Maria Carmina Scala +7 more
doaj +2 more sources