Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains [PDF]
Molecules, 2022 An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields.
Parul Sahrawat +6 more
doaj +2 more sources
Cholinesterases inhibition profiles with Ugi-derived peptidemimetics: A combined experimental and computational study. [PDF]
ADMET DMPKBackground and purpose: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are crucial enzymes implicated in various neurological disorders, including Alzheimer’s disease.
Ramić A +9 more
europepmc +2 more sources
Therapeutic potential of peptidomimetics of suppressors of cytokine signaling (SOCS) proteins in rheumatic disorders. [PDF]
Front Med (Lausanne)Dysregulation of the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway is increasingly recognized as a central molecular hallmark in the pathogenesis of multiple rheumatic diseases. Suppressors of cytokine signaling (SOCS)
Cugudda A, Marasco D.
europepmc +2 more sources
Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs
Molecules, 2017 The rapid emergence of multidrug-resistant pathogens has evolved into a global health problem as current treatment options are failing for infections caused by pan-resistant bacteria.
Natalia Molchanova +2 more
exaly +3 more sources
Evaluation of the Synergistic Activity of Antimicrobial Peptidomimetics or Colistin Sulphate with Conventional Antifungals Against Yeasts of Medical Importance. [PDF]
J Fungi (Basel)With rising multidrug-resistant yeast pathogens, conventional antifungals are becoming less effective, urging the need for adjuvants that enhance their activity at lower doses.
Mishra SK +12 more
europepmc +2 more sources
Inhibition of Human Coronavirus 229E by Lactoferrin-Derived Peptidomimetics. [PDF]
PharmaceuticsBackground/Objectives: Viral respiratory infections have a significant impact on global health and the economy. While vaccines are effective in preventing infection, they might not be available or sufficient when used alone and must be complemented by ...
Scala MC +7 more
europepmc +2 more sources
Thiazole peptidomimetics as chemical modulators of <i>KRAS</i> gene expression <i>via</i> G-quadruplex stabilization. [PDF]
RSC Chem BiolKRAS is one of the most frequently mutated oncogenes in human cancers and remains a challenging target for therapeutic intervention, often labeled “undruggable.” We herein synthesized triazole-containing peptidomimetics TTh1 and TTh2, to explore their ...
Biswas D +5 more
europepmc +2 more sources
THE INFLUENCE OF PHOTOSENSITIVE PEPTIDOMIMETICS ON WEIGHT INDICES OF IMMUNE ORGANS OF EXPERIMENTAL ANIMALS WITH TRANSPLANTABLE LEWIS LUNG CARCINOMA [PDF]
Biotechnologia Acta, 2022 The use of photodynamic therapy of drugs capable of selective accumulation in the tumor or in affected cells, in particular photosensitive peptidomimetics, increases its effectiveness in various treatment schemes. Aim. Determination of weight indices (
Volodkina D. +4 more
doaj +1 more source
Molecules, 2023 The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P® (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a biomimetic ...
Alexia Mattellone +7 more
doaj +1 more source
Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
Pharmaceuticals, 2021 Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova +2 more
doaj +1 more source