Results 1 to 10 of about 16,050 (209)

Peptidomimetics in cancer targeting

Molecular Medicine, 2022
The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression.
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan   +9 more
doaj   +3 more sources

Short Cationic Peptidomimetic Antimicrobials [PDF]

Antibiotics, 2019
The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to
Rajesh Kuppusamy, Mark Willcox, David StC. Black, Naresh Kumar   +3 more
doaj   +4 more sources

Therapeutic potential of peptidomimetics of suppressors of cytokine signaling (SOCS) proteins in rheumatic disorders [PDF]

Frontiers in Medicine
Dysregulation of the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway is increasingly recognized as a central molecular hallmark in the pathogenesis of multiple rheumatic diseases. Suppressors of cytokine signaling (SOCS)
Alessia Cugudda, Daniela Marasco
doaj   +2 more sources

Evaluation of the Synergistic Activity of Antimicrobial Peptidomimetics or Colistin Sulphate with Conventional Antifungals Against Yeasts of Medical Importance [PDF]

Journal of Fungi
With rising multidrug-resistant yeast pathogens, conventional antifungals are becoming less effective, urging the need for adjuvants that enhance their activity at lower doses.
Shyam Kumar Mishra, Rajesh Kuppusamy, Christina Nguyen, Jennifer Doeur, Harleen Atwal, Samuel Attard, Kristian Sørensen, Jennifer S. Lin, Edgar H. H. Wong, Alex Hui, Annelise E. Barron, Naresh Kumar, Mark Willcox   +12 more
doaj   +2 more sources

Inhibition of Human Coronavirus 229E by Lactoferrin-Derived Peptidomimetics [PDF]

Pharmaceutics
Background/Objectives: Viral respiratory infections have a significant impact on global health and the economy. While vaccines are effective in preventing infection, they might not be available or sufficient when used alone and must be complemented by ...
Maria Carmina Scala, Magda Marchetti, Martina Landi, Marialuigia Fantacuzzi, Fabiana Superti, Mariangela Agamennone, Pietro Campiglia, Marina Sala   +7 more
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Peptidomimetics [PDF]

Accounts of Chemical Research, 2008
Topic: Synthetic Molecules as Tools for Chemical Biology, Synthetic Proteins to Explore Biology.
Wu, Yun-Dong, Gellman, Sam
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THE INFLUENCE OF PHOTOSENSITIVE PEPTIDOMIMETICS ON WEIGHT INDICES OF IMMUNE ORGANS OF EXPERIMENTAL ANIMALS WITH TRANSPLANTABLE LEWIS LUNG CARCINOMA [PDF]

Biotechnologia Acta, 2022
The use of photodynamic therapy of drugs capable of selective accumulation in the tumor or in affected cells, in particular photosensitive peptidomimetics, increases its effectiveness in various treatment schemes. Aim. Determination of weight indices (
Volodkina D., Stupak I., Senchylo N., Molozhava O., Garmanchuk L.   +4 more
doaj   +1 more source

Fast Solution-Phase and Liquid-Phase Peptide Syntheses (SolPSS and LPPS) Mediated by Biomimetic Cyclic Propylphosphonic Anhydride (T3P^®)

Molecules, 2023
The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P® (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a biomimetic ...
Alexia Mattellone, Dario Corbisiero, Paolo Cantelmi, Giulia Martelli, Chiara Palladino, Alessandra Tolomelli, Walter Cabri, Lucia Ferrazzano   +7 more
doaj   +1 more source

Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains

Molecules, 2022
An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields.
Parul Sahrawat, Paweł Kowalczyk, Dominik Koszelewski, Mateusz Szymczak, Karol Kramkowski, Aleksandra Wypych, Ryszard Ostaszewski   +6 more
doaj   +1 more source

Binding Modes of Peptidomimetics Designed to Inhibit STAT3 [PDF]

, 2012
STAT3 is a transcription factor that has been found to be constitutively activated in a number of human cancers. Dimerization of STAT3 via its SH2 domain and the subsequent translocation of the dimer to the nucleus leads to transcription of anti ...
A Kamb, AC Anderson, AC Pierce, AN Jain, Ankur Dhanik, B Kuhn, B Raveh, BK Shoichet, C Hetényi, CN Cavasotto, CN Cavasotto, D Bhasin, D Plewczynski, D Plewczynski, DB Kitchen, DE Levy, DR Coleman, E Kellenberger, EF Pettersen, G Jones, G Schneider, GC Terstappen, GL Warren, GM Morris, GM Morris, HJC Berendsen, HM Berman, I Kuntz, I Massova, I Park, IG Khalil, IW Kuntz, J Darnell, J Schust, J Wang, JA DiMasi, JA Erickson, JA Hartigan, JB Cross, JC Owicki, Jie Zheng, JM Reichert, John S. McMurray, JP Rogers, JS Isaccs, JS McMurray, JW Shay, K Onodera, L Xing, Lydia E. Kavraki, M Karplus, M Mangoni, M Rarey, M Stahl, MM Moasser, MW Chang, MW Chang, N Li, N Okimoto, O Trott, P Weber, PA Kollman, PK Mandal, PK Mandal, PK Mandal, R Abagyan, R Buettner, R García-Nieto, R Wang, RA Friesner, RC Wade, S Becker, S Kaushik, S Morgan, SJ Projan, SK Panigrahi, T Bowman, T Darden, X Li, X Mao, X Xu, Y Cheng, Y Hua   +82 more
core   +12 more sources