Results 21 to 30 of about 10,137 (233)
Nano-G<sub>s</sub> Protein Peptidomimetics: Rational Design of Gα C-Terminus-Derived Peptides Mimicking Key Components of G<sub>s</sub>-β<sub>2</sub>AR Interactions. [PDF]
Angew Chem Int Ed EnglG protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Tran PT +11 more
europepmc +2 more sources
Universal Peptidomimetics [PDF]
Journal of the American Chemical Society, 2010 This paper concerns peptidomimetic scaffolds that can present side chains in conformations resembling those of amino acids in secondary structures without incurring excessive entropic or enthalpic penalties. Compounds of this type are referred to here as minimalist mimics.
Eunhwa, Ko +5 more
openaire +2 more sources
Synthesis of Isopeptide Epoxide Peptidomimetics
, 2016 Two epoxide-containing peptidomimetics of the isopeptide, glutamyl-γ-glutamate, have been synthesized via a route that should be generally applicable to the synthesis of isopeptide analogues in which an oxirane replaces the scissile peptide bond. Enzymes
Matthew D. Alexander (1444090) +2 more
core +6 more sources
Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
iScience, 2021 Summary: Cancer stem cells (CSCs) are documented to play a key role in tumorigenesis and therapy resistance. Despite significant progress in clinical oncology, CSC reservoirs remain elusive and difficult to eliminate.
Angelique N. Masibag +9 more
doaj +1 more source
Biomolecules, 2023 This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary ...
Tarsila G. Castro +4 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2023 Heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) work together as a molecular chaperone complex to regulate the activity of a multitude of client protein kinases.
Surya Sukumaran +7 more
doaj +1 more source
Peptides and peptidomimetics as prototypes [PDF]
Current Opinion in Chemical Biology, 2008 Since the unraveling of the structure of the α-helix [1] and β-sheet [2] by smart modeling, the use of peptides and their mimetics has been a highly fruitful approach that continues to attract natural scientists. These molecules occupy a privileged place in chemical biology, being both readily accessible via chemical synthesis and directly relevant to ...
Helma, Wennemers, Ronald T, Raines
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2019 Synthetic peptidomimetics may be designed to mimic functions of antimicrobial peptides, including potentiation of antibiotics, yet possessing improved pharmacological properties.
Kristin R. Baker +8 more
doaj +1 more source
Peptides and Peptidomimetics as Immunomodulators [PDF]
Immunotherapy, 2014 Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the conformational aspects of peptides,
Ameya S, Gokhale +1 more
openaire +2 more sources
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.
PLoS ONE, 2014 A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic ...
Fouad Brahimi +4 more
doaj +1 more source