Results 21 to 30 of about 11,458 (225)

Synthesis of Isopeptide Epoxide Peptidomimetics

, 2016
Two epoxide-containing peptidomimetics of the isopeptide, glutamyl-γ-glutamate, have been synthesized via a route that should be generally applicable to the synthesis of isopeptide analogues in which an oxirane replaces the scissile peptide bond. Enzymes
Matthew D. Alexander (1444090), Debatosh Majumdar (2397340), James K. Coward (2298190)   +2 more
core   +6 more sources

Non-Canonical Amino Acids as Building Blocks for Peptidomimetics: Structure, Function, and Applications

Biomolecules, 2023
This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary ...
Tarsila G. Castro, Manuel Melle-Franco, Cristina E. A. Sousa, Artur Cavaco-Paulo, João C. Marcos   +4 more
doaj   +1 more source

Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics

Frontiers in Cellular and Infection Microbiology, 2019
Synthetic peptidomimetics may be designed to mimic functions of antimicrobial peptides, including potentiation of antibiotics, yet possessing improved pharmacological properties.
Kristin R. Baker, Kristin R. Baker, Bimal Jana, Bimal Jana, Anna Mette Hansen, Hanne Mørck Nielsen, Henrik Franzyk, Luca Guardabassi, Luca Guardabassi   +8 more
doaj   +1 more source

Rational design, synthesis and structural characterization of peptides and peptidomimetics to target Hsp90/Cdc37 interaction for treating hepatocellular carcinoma

Computational and Structural Biotechnology Journal, 2023
Heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) work together as a molecular chaperone complex to regulate the activity of a multitude of client protein kinases.
Surya Sukumaran, Mingdian Tan, Shulamit Fluss Ben-Uliel, Hui Zhang, Marta De Zotti, Mei-Sze Chua, Samuel K. So, Nir Qvit   +7 more
doaj   +1 more source

Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.

PLoS ONE, 2014
A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic ...
Fouad Brahimi, Eunhwa Ko, Andrey Malakhov, Kevin Burgess, H Uri Saragovi   +4 more
doaj   +1 more source

Development of peptidomimetic ligands of Pro-Leu-Gly-NH2 as allosteric modulators of the dopamine D2 receptor

Beilstein Journal of Organic Chemistry, 2013
A variety of stable, small-molecule peptidomimetic ligands have been developed to elucidate the mechanism by which the neuropeptide Pro-Leu-Gly-NH2 (PLG) modulates dopaminergic neurotransmission.
Swapna Bhagwanth, Ram K. Mishra, Rodney L. Johnson   +2 more
doaj   +1 more source

Cell-free Biosynthesis of Peptidomimetics

, 2023
A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein synthesis (CFPS) systems. A key feature of these peptidomimetic drugs is the use of
Lee, Kanghun, Lee, Joongoo, Jewett, Michael C., Kim, Inseon, Willi, Jessica A., Cho, Namjin   +5 more
core   +1 more source

Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds

Frontiers in Chemistry, 2018
An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics.
Lisa Moni, Fabio De Moliner, Silvia Garbarino, Jörn Saupe, Christian Mang, Andrea Basso   +5 more
doaj   +1 more source

Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool

Marine Drugs, 2021
Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins.
Yang Li, Wang Li, Zhengshuang Xu
doaj   +1 more source

A readily applicable strategy to convert peptides to peptoid-based therapeutics. [PDF]

PLoS ONE, 2013
Incorporation of unnatural amino acids and peptidomimetic residues into therapeutic peptides is highly efficacious and commonly employed, but generally requires laborious trial-and-error approaches.
Minyoung Park, Modi Wetzler, Theodore S Jardetzky, Annelise E Barron   +3 more
doaj   +1 more source