Results 21 to 30 of about 16,050 (209)
Designing Peptidomimetics [PDF]
Current Topics in Medicinal Chemistry, 2018 The concept of a peptidomimetic was coined about forty years ago. Since then, enormous effort and interest have been devoted to mimic the properties of peptides with small molecules or pseudopeptides. The present report aims to review different approaches described in the past to succeed in this goal.
openaire +4 more sources
Frontiers in Cellular and Infection Microbiology, 2019 Synthetic peptidomimetics may be designed to mimic functions of antimicrobial peptides, including potentiation of antibiotics, yet possessing improved pharmacological properties.
Kristin R. Baker +8 more
doaj +1 more source
Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing [PDF]
, 2018 Staphylococcus aureus is an important pathogen causing infections in humans and animals. Increasing problems with antimicrobial resistance has prompted the development of alternative treatment strategies, including antivirulence approaches targeting ...
Baldry, Mara +8 more
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Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.
PLoS ONE, 2014 A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic ...
Fouad Brahimi +4 more
doaj +1 more source
Uracil-Peptide-Pyrene Conjugates as Cu<sup>2+</sup>-Sensitive Probes Targeting DNA, RNA, and Biorelevant Model Membranes. [PDF]
ChembiochemWe introduce uracil–triazole–pyrene peptidomimetics whose tunable peptide linkers precisely control light emission, copper binding, and interactions with DNA and RNA. Fine structural adjustments unlock selective biomolecular recognition and striking metal‐ and membrane‐responsive fluorescence, paving the way for a new generation of multifunctional ...
Pavlović Saftić D +2 more
europepmc +2 more sources
Crystal structure of 4,4-dimethyl-2-(trifluoromethyl)-4,5-dihydro-1H-imidazole, C6H9F3N2 [PDF]
, 2019 C6H9F3N2, monoclinic, P21/n (no. 14), a = 10.6224(9) Å, b = 11.8639(9) Å, c = 13.3139(11) Å, β = 105.903(3)°, V = 1613.6(2) Å3, Z = 8, Rgt(F) = 0.0618, wRref(F2) = 0.1629, T = 102(2) K [1–3]
Lentz, Dieter +4 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2013 A variety of stable, small-molecule peptidomimetic ligands have been developed to elucidate the mechanism by which the neuropeptide Pro-Leu-Gly-NH2 (PLG) modulates dopaminergic neurotransmission.
Swapna Bhagwanth +2 more
doaj +1 more source
Connexin communication compartments and wound repair in epithelial tissue [PDF]
, 2018 Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they ...
Chanson, Marc +4 more
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Frontiers in Chemistry, 2018 An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics.
Lisa Moni +5 more
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A facile route for the synthesis of novel S-linked 1,3,5-triazine tethered peptidomimetics [PDF]
, 2014 An efficient one-pot synthesis of Nα-protected S-linked 1,3,5-triazine tethered peptidomimetics is described. The protocol involves a three-component condensation reaction employing Nα-protected amino alkyl isothiouronium salt, formaldehyde and amino ...
Basavaprabhu, . +3 more
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