Results 41 to 50 of about 11,458 (225)
The Use of Peptides in the Treatment of Fragile X Syndrome: Challenges and Opportunities
Frontiers in Psychiatry, 2021 Fragile X Syndrome (FXS) is the most frequent cause of inherited intellectual disabilities and autism spectrum disorders, characterized by cognitive deficits and autistic behaviors.
Alice Romagnoli, Daniele Di Marino
doaj +1 more source
Molecules, 2023 Herein, advanced intermediates were synthesized through Ugi four-component reactions of isocyanides, aldehydes, masked amino aldehyde, and carboxylic acids, including N-protected amino acids.
Naděžda Cankařová, Viktor Krchňák
doaj +1 more source
Peptides and peptidomimetics as prototypes [PDF]
Current Opinion in Chemical Biology, 2008 Since the unraveling of the structure of the α-helix [1] and β-sheet [2] by smart modeling, the use of peptides and their mimetics has been a highly fruitful approach that continues to attract natural scientists. These molecules occupy a privileged place in chemical biology, being both readily accessible via chemical synthesis and directly relevant to ...
Helma, Wennemers, Ronald T, Raines
openaire +2 more sources
Advanced Science, EarlyView.This work designs a peptide‐free polyelectrolyte with stable, switchable conformations and near‐infrared fluorescence in water. It harnesses a cooperative Fe3+‐triggered sheet‐to‐helix transition to generate nonlinear fluorescence quenching, enabling the ultrasensitive, real‐time visualization of Fe3+ ion distribution and metabolic trafficking at ...
Yeqiang Zhou +9 more
wiley +1 more source
Promising antibiofilm activity of peptidomimetics [PDF]
, 2018 Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss.
Gnoatto, Simone Cristina Baggio +3 more
core +3 more sources
Peptidomimetics to mimic protein-protein interactions [PDF]
, 2005 Quenched Molecular Dynamics (QMD) used to explore molecular conformations was developed to operate in Insight II platform for two simulation engines: CHARMm and Discover.
Xia, Zebin
core +3 more sources
Advanced Science, EarlyView.This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo +6 more
wiley +1 more source
Development of Bioactive Peptidomimetics
, 2023 In the past two decades, a lot of different peptidomimetics, such as β-peptides, oligoureas, azapeptides, peptoids, aromatic oligoamides, and others, have been developed.
Wang, Lei
core
Advanced Science, EarlyView.This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng +9 more
wiley +1 more source
STAR ProtocolsSummary: Circular dichroism (CD) spectrometry is a rapid technique for detecting protein secondary structure, particularly helicity. DMSO is used to ensure optimal solubility of peptides/peptidomimetics; however, its background absorbance hinders ...
William H. Deni, Tong Gao, Jinhua Wu
doaj +1 more source