Results 31 to 40 of about 11,685 (174)

Peptidomimetics : A New Era in Drug Discovery

Journal of Pharmaceutical Research
Peptides are made up from amino acid sequences which possess importance in various biological processes, making them attractive candidates for therapeutic development.
Shubham N Karle, Shailaja B Jadhav, Nikita K Kale   +2 more
doaj   +1 more source

Short Cationic Peptidomimetic Antimicrobials

Antibiotics, 2019
The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to
Rajesh Kuppusamy, Mark Willcox, David StC. Black, Naresh Kumar   +3 more
doaj   +1 more source

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

Beilstein Journal of Organic Chemistry, 2014
In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues.
Gijs Koopmanschap, Eelco Ruijter, Romano V.A. Orru   +2 more
doaj   +1 more source

The Use of Peptides in the Treatment of Fragile X Syndrome: Challenges and Opportunities

Frontiers in Psychiatry, 2021
Fragile X Syndrome (FXS) is the most frequent cause of inherited intellectual disabilities and autism spectrum disorders, characterized by cognitive deficits and autistic behaviors.
Alice Romagnoli, Daniele Di Marino
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets-Then, Now, and the Future. [PDF]

Med Res Rev
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Sleebs BE.
europepmc   +2 more sources

Receptor‐Triggered Peptide Self‐Assembly Enables Multivalent Recruitment of Endogenous Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
Receptor‐triggered supramolecular self‐assembly converts monovalent antibody‐recruiting molecules into multivalent platforms directly on cancer cell membranes. The resulting fibrillar assemblies present clustered haptens that efficiently recruit endogenous antibodies, enabling selective complement‐mediated immune killing of EGFR‐positive cancer cells ...
Yihui Wang, Xia Wu, Chenguang Zhao, Hong Han, Wensha Xie, Dan Yuan, Junfeng Shi   +6 more
wiley   +1 more source

Synthetic route for the tripeptide peptidomimetics.

, 2015
Synthetic route for the tripeptide peptidomimetics.
Stephanie Tay (777269), Róisín M. McMahon (777270), Wilko Duprez (485319), Martin J. Stoermer (777268), David P. Fairlie (180958), Prabhakar Bachu (777267), Jennifer L. Martin (80694)   +6 more
core   +1 more source

Regioselective Cyclic Iminium Formation of Ugi Advanced Intermediates: Rapid Access to 3,4-Dihydropyrazin-2(1H)-ones and Other Diverse Nitrogen-Containing Heterocycles

Molecules, 2023
Herein, advanced intermediates were synthesized through Ugi four-component reactions of isocyanides, aldehydes, masked amino aldehyde, and carboxylic acids, including N-protected amino acids.
Naděžda Cankařová, Viktor Krchňák
doaj   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

Protocol for reconstituting peptides/peptidomimetics from DMSO to aqueous buffers for circular dichroism analyses

STAR Protocols
Summary: Circular dichroism (CD) spectrometry is a rapid technique for detecting protein secondary structure, particularly helicity. DMSO is used to ensure optimal solubility of peptides/peptidomimetics; however, its background absorbance hinders ...
William H. Deni, Tong Gao, Jinhua Wu
doaj   +1 more source