Marine Drugs, 2021 Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins.
Yang Li, Wang Li, Zhengshuang Xu
doaj +1 more source
In vitro activities of novel 4-HPR derivatives on a panel of rhabdoid and other tumor cell lines [PDF]
, 2011 Background Rhabdoid tumors (RTs) are aggressive pediatric malignancies with poor prognosis. N-(4-hydroxy phenyl) retinamide (4-HPR or fenretinide) is a potential chemotherapeutic for RTs with activity correlated to its ability to down-modulate Cyclin D1.
Melissa E Smith +2 more
core +2 more sources
A readily applicable strategy to convert peptides to peptoid-based therapeutics. [PDF]
PLoS ONE, 2013 Incorporation of unnatural amino acids and peptidomimetic residues into therapeutic peptides is highly efficacious and commonly employed, but generally requires laborious trial-and-error approaches.
Minyoung Park +3 more
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Computational Studies on Structural, Excitation, and Charge-Transfer Properties of Ureidopeptidomimetics [PDF]
, 2016 Peptides with ureido group enclosing backbones are considered peptidomimetics and are known for their higher stabilities, biocompatibilities, antibiotic, inhibitor, and charge-transduction activities. These peptidomimetics have some unique applications,
Joy Sherin, . +2 more
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Impact of α-hydrazino acids embedded in short fluorescent peptides on peptide interaction with DNA and RNA [PDF]
, 2016 Series of novel hydrazino-based peptidomimetics and analogues comprising N-terminal lysine and C-terminal phenanthridinyl-L-alanine were prepared. Presented results demonstrate up till now unknown possibility to finely modulate peptide interaction with ...
Glavaš-Obrovac, Ljubica +5 more
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A simple approach for the synthesis of new classes of dithiocarbamate-linked peptidomimetics [PDF]
, 2009 An efficient protocol for the synthesis of a new series of dithiocarbamate-linked peptidomimetics is described. The in situ generated dithiocarbamic acid intermediate formed by the reaction of an amino acid ester and carbon disulfide in the presence of ...
Hemantha, H.P., Sureshbabu, V.V.
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Cyclic RGD peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands [PDF]
, 2012 The synthesis of eight bifunctional diketopiperazine (DKP) scaffolds is described; these were formally derived from 2,3-diaminopropionic acid and aspartic acid (DKP-1-DKP-7) or glutamic acid (DKP-8) and feature an amine and a carboxylic acid functional ...
Arosio D. +9 more
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Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics
Beilstein Journal of Organic Chemistry, 2014 In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues.
Gijs Koopmanschap +2 more
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The Use of Peptides in the Treatment of Fragile X Syndrome: Challenges and Opportunities
Frontiers in Psychiatry, 2021 Fragile X Syndrome (FXS) is the most frequent cause of inherited intellectual disabilities and autism spectrum disorders, characterized by cognitive deficits and autistic behaviors.
Alice Romagnoli, Daniele Di Marino
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Synthesis and Conformational Studies of Peptidomimetics Containing a New Bifunctional Diketopiperazine Scaffold Acting as a \u3b2-Hairpin Inducer [PDF]
, 2008 A practical synthesis of a new bifunctional diketopiperazine (DKP) scaffold 1, formally derived from the cyclization of L-aspartic acid and (S)-2,3-diaminopropionic acid, is reported.
Belvisi, L. +5 more
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