Results 11 to 20 of about 11,685 (174)
Peptidomimetics Therapeutics for Retinal Disease
Biomolecules, 2021 Ocular disorders originating in the retina can result in a partial or total loss of vision, making drug delivery to the retina of vital importance.
Dylan E. Parsons +6 more
doaj +2 more sources
Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development
Frontiers in Chemistry, 2021 Peptidomimetics play a fundamental role in drug design due to their preferential properties regarding natural peptides. In particular, compounds possessing nitrogen-containing heterocycles have been intensively studied in recent years.
Agnieszka Staśkiewicz +6 more
doaj +1 more source
Peptidomimetics as Potential Anti-Virulence Drugs Against Resistant Bacterial Pathogens
Frontiers in Microbiology, 2022 The uncontrollable spread of superbugs calls for new approaches in dealing with microbial-antibiotic resistance. Accordingly, the anti-virulence approach has arisen as an attractive unconventional strategy to face multidrug-resistant pathogens.
Osmel Fleitas Martínez +4 more
doaj +1 more source
Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
iScience, 2021 Summary: Cancer stem cells (CSCs) are documented to play a key role in tumorigenesis and therapy resistance. Despite significant progress in clinical oncology, CSC reservoirs remain elusive and difficult to eliminate.
Angelique N. Masibag +9 more
doaj +1 more source
Designing Peptidomimetics [PDF]
, 2018 The concept of a peptidomimetic was coined about forty years ago. Since then, an enormous effort and interest has been devoted to mimic the properties of peptides with small molecules or pseudopeptides.
Juan J. Perez +1 more
core +1 more source
Well-Tempered MetaDynamics based method to evaluate universal peptidomimetics [PDF]
, 2018 Peptidomimetics are a broad family of compounds designed to mimic the main structural features of peptides, avoiding their metabolic drawbacks. In particular, universal peptidomimetics use only peptide side-chain analogs to mimic different secondary ...
GANDINI, ENRICO +4 more
core +1 more source
Peptidomimetics in cancer targeting
Molecular Medicine, 2022 The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression.
Mohammad Mahmoudi Gomari +9 more
doaj +1 more source
Biomolecules, 2023 This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary ...
Tarsila G. Castro +4 more
doaj +1 more source
Synthesis of Isopeptide Epoxide Peptidomimetics
, 2016 Two epoxide-containing peptidomimetics of the isopeptide, glutamyl-γ-glutamate, have been synthesized via a route that should be generally applicable to the synthesis of isopeptide analogues in which an oxirane replaces the scissile peptide bond. Enzymes
Matthew D. Alexander (1444090) +2 more
core +6 more sources
Frontiers in Cellular and Infection Microbiology, 2019 Synthetic peptidomimetics may be designed to mimic functions of antimicrobial peptides, including potentiation of antibiotics, yet possessing improved pharmacological properties.
Kristin R. Baker +8 more
doaj +1 more source