Results 11 to 20 of about 11,458 (225)
Accounts of Chemical Research, 2008 Topic: Synthetic Molecules as Tools for Chemical Biology, Synthetic Proteins to Explore Biology.
Wu, Yun-Dong, Gellman, Sam
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THE INFLUENCE OF PHOTOSENSITIVE PEPTIDOMIMETICS ON WEIGHT INDICES OF IMMUNE ORGANS OF EXPERIMENTAL ANIMALS WITH TRANSPLANTABLE LEWIS LUNG CARCINOMA [PDF]
Biotechnologia Acta, 2022 The use of photodynamic therapy of drugs capable of selective accumulation in the tumor or in affected cells, in particular photosensitive peptidomimetics, increases its effectiveness in various treatment schemes. Aim. Determination of weight indices (
Volodkina D. +4 more
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Molecules, 2023 The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P® (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a biomimetic ...
Alexia Mattellone +7 more
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Molecules, 2022 An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields.
Parul Sahrawat +6 more
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Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
Pharmaceuticals, 2021 Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova +2 more
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Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development
Frontiers in Chemistry, 2021 Peptidomimetics play a fundamental role in drug design due to their preferential properties regarding natural peptides. In particular, compounds possessing nitrogen-containing heterocycles have been intensively studied in recent years.
Agnieszka Staśkiewicz +6 more
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Peptidomimetics as Potential Anti-Virulence Drugs Against Resistant Bacterial Pathogens
Frontiers in Microbiology, 2022 The uncontrollable spread of superbugs calls for new approaches in dealing with microbial-antibiotic resistance. Accordingly, the anti-virulence approach has arisen as an attractive unconventional strategy to face multidrug-resistant pathogens.
Osmel Fleitas Martínez +4 more
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Universal Peptidomimetics [PDF]
Journal of the American Chemical Society, 2010 This paper concerns peptidomimetic scaffolds that can present side chains in conformations resembling those of amino acids in secondary structures without incurring excessive entropic or enthalpic penalties. Compounds of this type are referred to here as minimalist mimics.
Eunhwa, Ko +5 more
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Design and Synthesis of Novel Peptidomimetics for Cancer Immunotherapy [PDF]
, 2020 Tumor cells benefit from some certain signals, which are referred to as “immune checkpoints”, to escape immune-mediated destruction. With that in mind, it is believed that the blockade of these points, such as programmed cell death Ligand-1 (PD-L1) and ...
Zeynep, Tuğay +11 more
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Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
iScience, 2021 Summary: Cancer stem cells (CSCs) are documented to play a key role in tumorigenesis and therapy resistance. Despite significant progress in clinical oncology, CSC reservoirs remain elusive and difficult to eliminate.
Angelique N. Masibag +9 more
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