Results 11 to 20 of about 10,137 (233)
Designing Peptidomimetics [PDF]
Current Topics in Medicinal Chemistry, 2018 The concept of a peptidomimetic was coined about forty years ago. Since then, enormous effort and interest have been devoted to mimic the properties of peptides with small molecules or pseudopeptides. The present report aims to review different approaches described in the past to succeed in this goal.
Juan J. Perez +1 more
openaire +5 more sources
Molecular Informatics, 2020 AbstractEndogenous peptides as part of physiological processes are targets of interest when it comes to finding desirable therapeutics which are able to modulate molecular interactions. The major limits presented by peptides when they are used as drugs have motivated the research of the synthesis of peptidomimetics obtained through chemical ...
Tomasella Cristina +4 more
openaire +4 more sources
Peptidomimetics Therapeutics for Retinal Disease
Biomolecules, 2021 Ocular disorders originating in the retina can result in a partial or total loss of vision, making drug delivery to the retina of vital importance.
Dylan E. Parsons +6 more
doaj +2 more sources
Peptidomimetics in cancer targeting
Molecular Medicine, 2022 The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression.
Mohammad Mahmoudi Gomari +9 more
doaj +3 more sources
Thiazoles in Peptides and Peptidomimetics [PDF]
, 2015 The natural occurrence of the thiazole ring in chemistry and biology has inspired its widespread use in synthetic peptidomimetics as structural templates, biological probes, and pharmaceuticals. Thiazole can be viewed as a dehydrated cyclized derivative of cysteine, incorporated into peptide sequences through chemical synthesis or ribosomal ...
Mak, Jeffrey Y. W. +2 more
openaire +4 more sources
Cell-free Biosynthesis of Peptidomimetics
Biotechnology and Bioprocess Engineering, 2023 A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein synthesis (CFPS) systems. A key feature of these peptidomimetic drugs is the use of non-canonical amino acid building blocks with diverse biochemical properties that expand functional
Lee, Kanghun +5 more
openaire +4 more sources
Antimicrobial Cyclic Peptidomimetics
Macromolecular Rapid Communications, EarlyView.Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley +3 more sources
Promising Antibiofilm Activity of Peptidomimetics [PDF]
Frontiers in Microbiology, 2018 Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss. Scientific efforts have been made over the past few decades, but so far there is no effective treatment targeting the bacteria in biofilms. Antimicrobial peptidomimetics have been proposed
Rafael Gomes Von Borowski +4 more
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Short Cationic Peptidomimetic Antimicrobials [PDF]
Antibiotics, 2019 The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to
Rajesh Kuppusamy +3 more
doaj +4 more sources
Accounts of Chemical Research, 2008 Topic: Synthetic Molecules as Tools for Chemical Biology, Synthetic Proteins to Explore Biology.
Wu, Yun-Dong, Gellman, Sam
+6 more sources