Results 1 to 10 of about 14,095 (224)

Adaptive evolution of Escherichia coli to an α-peptide/β-peptoid peptidomimetic induces stable resistance. [PDF]

PLoS ONE, 2013
Antimicrobial peptides (AMPs) and synthetic analogues thereof target conserved structures of bacterial cell envelopes and hence, development of resistance has been considered an unlikely event.
Line Hein-Kristensen, Henrik Franzyk, Anne Holch, Lone Gram   +3 more
doaj   +3 more sources

SARS-CoV-2 main protease inhibition through dimerization promotion by peptidomimetic inhibitors and disruption by ebselen [PDF]

eLife
The SARS-CoV-2 main protease (Mpro) is a key antiviral target that equilibrates between an active dimer and inactive monomer, making the dimerization interface a promising therapeutic vulnerability.
Chengxi Liu, Qinyu Jia, Chang Zhao, Zhong-Ping Yao   +3 more
doaj   +2 more sources

Exploring covalent inhibitors of SARS-CoV-2 main protease: from peptidomimetics to novel scaffolds [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Peptidomimetic inhibitors mimic natural peptide substrates, employing electrophilic warheads to covalently interact with the catalytic Cys145 of Mpro.
Noor Atatreh, Radwa E. Mahgoub, Mohammad A. Ghattas   +2 more
doaj   +2 more sources

Conjugation of Antibiotics to Peptidomimetics Enhances Antimicrobial Spectrum of Activity [PDF]

Antibiotics
Background/Objectives: Antimicrobial conjugates have attracted considerable interest in addressing the threat of antimicrobial resistance by minimising the likelihood of resistance onset.
Joshua Fleming, Nathan James Carey, Yao Cheng, Hao Luo, Tsz Tin Yu, Mark D. P. Willcox, David StC Black, Edgar H. H. Wong, Naresh Kumar   +8 more
doaj   +2 more sources

Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters

Frontiers in Chemistry, 2021
Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan, Anna Meschkov, Anna Meschkov, Ute Schepers, Ute Schepers, Stefan Bräse, Stefan Bräse   +6 more
doaj   +1 more source

The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid

Pharmaceuticals, 2023
Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens,
Valeria Cafaro, Andrea Bosso, Ilaria Di Nardo, Assunta D’Amato, Irene Izzo, Francesco De Riccardis, Marialuisa Siepi, Rosanna Culurciello, Nunzia D’Urzo, Emiliano Chiarot, Antonina Torre, Elio Pizzo, Marcello Merola, Eugenio Notomista   +13 more
doaj   +1 more source

Identification and Application of Two Promising Peptide Ligands for the Immunodetection of Imidacloprid Residue

Foods, 2022
As the most widely used neonicotinoid insecticide, it is of great significance to explore the immunoreagents and immunoassays for imidacloprid (IMI) residue.
Tianyang You, Yuan Ding, Yue Huang, Yang Lu, Minghua Wang, Xiude Hua   +5 more
doaj   +1 more source

Peptide–Protein Interactions: From Drug Design to Supramolecular Biomaterials

Molecules, 2021
The self-recognition and self-assembly of biomolecules are spontaneous processes that occur in Nature and allow the formation of ordered structures, at the nanoscale or even at the macroscale, under thermodynamic and kinetic equilibrium as a consequence ...
Andrea Caporale, Simone Adorinni, Doriano Lamba, Michele Saviano   +3 more
doaj   +1 more source

Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery

Biomolecules, 2022
Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj   +1 more source

Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

Frontiers in Chemistry, 2021
Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug targets because they can produce fewer on-target side effects, improved selectivity, and better biological specificity (e.g., biased signaling or probe dependence) than
Keith M. Olson, John R. Traynor, John R. Traynor, Andrew Alt, Andrew Alt   +4 more
doaj   +1 more source