Results 1 to 10 of about 19,091 (188)

Exploring covalent inhibitors of SARS-CoV-2 main protease: from peptidomimetics to novel scaffolds [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Peptidomimetic inhibitors mimic natural peptide substrates, employing electrophilic warheads to covalently interact with the catalytic Cys145 of Mpro.
Noor Atatreh, Radwa E. Mahgoub, Mohammad A. Ghattas   +2 more
doaj   +2 more sources

Adaptive evolution of Escherichia coli to an α-peptide/β-peptoid peptidomimetic induces stable resistance. [PDF]

PLoS ONE, 2013
Antimicrobial peptides (AMPs) and synthetic analogues thereof target conserved structures of bacterial cell envelopes and hence, development of resistance has been considered an unlikely event.
Line Hein-Kristensen, Henrik Franzyk, Anne Holch, Lone Gram   +3 more
doaj   +5 more sources

Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations [PDF]

Molecules, 2016
A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites.
Ziniu Zhou, William L. Scott, Martin J. O’Donnell   +2 more
doaj   +4 more sources

Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters

Frontiers in Chemistry, 2021
Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan, Anna Meschkov, Anna Meschkov, Ute Schepers, Ute Schepers, Stefan Bräse, Stefan Bräse   +6 more
doaj   +1 more source

The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid

Pharmaceuticals, 2023
Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens,
Valeria Cafaro, Andrea Bosso, Ilaria Di Nardo, Assunta D’Amato, Irene Izzo, Francesco De Riccardis, Marialuisa Siepi, Rosanna Culurciello, Nunzia D’Urzo, Emiliano Chiarot, Antonina Torre, Elio Pizzo, Marcello Merola, Eugenio Notomista   +13 more
doaj   +1 more source

Identification and Application of Two Promising Peptide Ligands for the Immunodetection of Imidacloprid Residue

Foods, 2022
As the most widely used neonicotinoid insecticide, it is of great significance to explore the immunoreagents and immunoassays for imidacloprid (IMI) residue.
Tianyang You, Yuan Ding, Yue Huang, Yang Lu, Minghua Wang, Xiude Hua   +5 more
doaj   +1 more source

Peptide–Protein Interactions: From Drug Design to Supramolecular Biomaterials

Molecules, 2021
The self-recognition and self-assembly of biomolecules are spontaneous processes that occur in Nature and allow the formation of ordered structures, at the nanoscale or even at the macroscale, under thermodynamic and kinetic equilibrium as a consequence ...
Andrea Caporale, Simone Adorinni, Doriano Lamba, Michele Saviano   +3 more
doaj   +1 more source

Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery

Biomolecules, 2022
Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj   +1 more source

Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

Frontiers in Chemistry, 2021
Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug targets because they can produce fewer on-target side effects, improved selectivity, and better biological specificity (e.g., biased signaling or probe dependence) than
Keith M. Olson, John R. Traynor, John R. Traynor, Andrew Alt, Andrew Alt   +4 more
doaj   +1 more source

Binding Modes of Peptidomimetics Designed to Inhibit STAT3 [PDF]

, 2012
STAT3 is a transcription factor that has been found to be constitutively activated in a number of human cancers. Dimerization of STAT3 via its SH2 domain and the subsequent translocation of the dimer to the nucleus leads to transcription of anti ...
A Kamb, AC Anderson, AC Pierce, AN Jain, Ankur Dhanik, B Kuhn, B Raveh, BK Shoichet, C Hetényi, CN Cavasotto, CN Cavasotto, D Bhasin, D Plewczynski, D Plewczynski, DB Kitchen, DE Levy, DR Coleman, E Kellenberger, EF Pettersen, G Jones, G Schneider, GC Terstappen, GL Warren, GM Morris, GM Morris, HJC Berendsen, HM Berman, I Kuntz, I Massova, I Park, IG Khalil, IW Kuntz, J Darnell, J Schust, J Wang, JA DiMasi, JA Erickson, JA Hartigan, JB Cross, JC Owicki, Jie Zheng, JM Reichert, John S. McMurray, JP Rogers, JS Isaccs, JS McMurray, JW Shay, K Onodera, L Xing, Lydia E. Kavraki, M Karplus, M Mangoni, M Rarey, M Stahl, MM Moasser, MW Chang, MW Chang, N Li, N Okimoto, O Trott, P Weber, PA Kollman, PK Mandal, PK Mandal, PK Mandal, R Abagyan, R Buettner, R García-Nieto, R Wang, RA Friesner, RC Wade, S Becker, S Kaushik, S Morgan, SJ Projan, SK Panigrahi, T Bowman, T Darden, X Li, X Mao, X Xu, Y Cheng, Y Hua   +82 more
core   +7 more sources