Results 21 to 30 of about 12,487 (241)
Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery
Biomolecules, 2022 Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
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Frontiers in Chemistry, 2021 Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug targets because they can produce fewer on-target side effects, improved selectivity, and better biological specificity (e.g., biased signaling or probe dependence) than
Keith M. Olson +4 more
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Molecules, 2014 Our previous studies showed that alteration of dipeptides Y-Fca-Ala-OMe (III) into Y-Ala-Fca-OMe (IV) (Y = Ac, Boc; Fca = 1'-aminoferrocene-1-carboxylic acid) significantly influenced their conformational space.
Monika Kovačević +6 more
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Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture
Viruses, 2021 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more than two million deaths worldwide since it was first detected in 2019.
Allison Bakovic +7 more
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Peptidomimetics in cancer targeting
Molecular Medicine, 2022 AbstractThe low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides due to their small size and easy production compared to proteins are highly regarded in designing cancer vaccines and oncogenic pathway ...
Mohammad Mahmoudi Gomari +9 more
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Frontiers in Cellular and Infection Microbiology, 2019 Synthetic peptidomimetics may be designed to mimic functions of antimicrobial peptides, including potentiation of antibiotics, yet possessing improved pharmacological properties.
Kristin R. Baker +8 more
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Peptides and peptidomimetics as prototypes [PDF]
Current Opinion in Chemical Biology, 2008 Since the unraveling of the structure of the α-helix [1] and β-sheet [2] by smart modeling, the use of peptides and their mimetics has been a highly fruitful approach that continues to attract natural scientists. These molecules occupy a privileged place in chemical biology, being both readily accessible via chemical synthesis and directly relevant to ...
Helma, Wennemers, Ronald T, Raines
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Designing Peptidomimetics [PDF]
Current Topics in Medicinal Chemistry, 2018 The concept of a peptidomimetic was coined about forty years ago. Since then, enormous effort and interest have been devoted to mimic the properties of peptides with small molecules or pseudopeptides. The present report aims to review different approaches described in the past to succeed in this goal.
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Peptides and Peptidomimetics as Immunomodulators [PDF]
Immunotherapy, 2014 Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the conformational aspects of peptides,
Ameya S, Gokhale +1 more
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Frontiers in Chemistry, 2019 Unnatural amino acids have tremendously expanded the folding possibilities of peptides and peptide mimics. While α,α-disubstituted and β-amino acids are widely studied, γ-derivatives have been less exploited.
Francesco Oliva +5 more
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