Results 21 to 30 of about 17,763 (235)
ACS Infectious Diseases, 2021 The peptidomimetic H-[NLys-tBuAla]6-NH2 (CEP-136), which exhibits low inherent antimicrobial activity against Gram-negative bacteria (MIC = 16-64 μM), was shown to significantly potentiate the antibacterial activity of several clinically important ...
Elnaz Harifi Mood +8 more
semanticscholar +1 more source
Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture
Viruses, 2021 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more than two million deaths worldwide since it was first detected in 2019.
Allison Bakovic +7 more
doaj +1 more source
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.
RSC Medicinal Chemistry, 2021 Tragically, the death toll from the COVID-19 pandemic continues to rise, and with variants being observed around the globe new therapeutics, particularly direct-acting antivirals that are easily administered, are desperately needed. Studies targeting the
Bing Bai +16 more
semanticscholar +1 more source
Copper chelating cyclic peptidomimetic inhibits Aβ fibrillogenesis.
RSC Medicinal Chemistry, 2022 Misfolding of the amyloid-β peptide (Aβ) and its subsequent aggregation into toxic oligomers is one of the leading causes of Alzheimer's disease (AD). As a therapeutic approach, cyclic peptides have been modified in many ways and developed as a potential
S. Kalita +6 more
semanticscholar +1 more source
Bioorganic & Medicinal Chemistry Letters, 2021 The COVID-19 pandemic caused by SARS-CoV-2 has created an unprecedented global health emergency. As of July 2021, only three antiviral therapies have been approved by the FDA for treating infected patients, highlighting the urgent need for more ...
semanticscholar +1 more source
Beilstein Journal of Organic Chemistry, 2023 Peptidomimetics with a substituted imidazo[1,2-a]pyridine fragment were synthesized by a tandem of Groebke–Blackburn–Bienaymé and Ugi reactions. The target products contain substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores ...
Oleksandr V. Kolomiiets +5 more
doaj +1 more source
QSAR Modelling of Peptidomimetic Derivatives towards HKU4-CoV 3CLpro Inhibitors against MERS-CoV
Chemistry, 2021 In this paper, we report the relationship between the anti-MERS-CoV activities of the HKU4 derived peptides for some peptidomimetic compounds and various descriptors using the quantitative structure activity relationships (QSAR) methods.
Imad Hammoudan +4 more
doaj +1 more source
A pH-sensitive liposome formulation of a peptidomimetic-Dox conjugate for targeting HER2 + cancer
International journal of pharmaceutics, 2021 Cancer treatment faces the challenge of selective delivery of the cytotoxic drug to the desired site of action to minimize undesired side effects.
Jafrin Jobayer Sonju +7 more
semanticscholar +1 more source
1,2,3-Triazoles as Biomimetics in Peptide Science
Molecules, 2021 Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo.
Naima Agouram +2 more
doaj +1 more source
Pharmaceuticals, 2023 Vascular endothelial growth factor receptor 2 (VEGFR2) mediates VEGFA signaling mainly through the PI3K/AKT/mTOR and PLCγ/ERK1/2 pathways. Here we unveil a peptidomimetic (VGB3) based on the interaction between VEGFB and VEGFR1 that unexpectedly binds ...
Mohadeseh Namjoo +8 more
doaj +1 more source