Results 1 to 10 of about 3,952 (212)
A Peptoid-Based Fluorescent Sensor for Cyanide Detection
Molecules, 2016 Peptoids, N-substituted glycine oligomers, are versatile peptidomimetics with diverse biomedical applications. However, strategies to the development of novel fluorescent peptoids as chemical sensors have not been extensively explored, yet.
Jeeyeon Lee, Bumhee Lim
exaly +4 more sources
Amphipathic peptoid transporters for protein and nanoparticle delivery [PDF]
RSC AdvancesThe development of efficient intracellular delivery vectors requires a precise balance between cellular uptake and minimal cytotoxicity. Here, we describe a series of cationic amphipathic peptoids designed to evaluate how sequence variation controls cell
Juhye Shin +7 more
doaj +2 more sources
Topology-Dependent Antifreeze Properties of Biomimetic Linear and Star-Shaped Peptoids [PDF]
BiomimeticsDeveloping safe and efficient cryoprotectants is critical for effective cryopreservation in biomedical applications. Inspired by natural antifreeze proteins (AFPs), a series of linear and star-shaped peptoids featuring isopropanol side chains to mimic ...
Lei Feng +7 more
doaj +2 more sources
Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs
Separations, 2021 Membranes for use in high gas exchange lung applications are riddled with fouling. The goal of this research is to create a membrane that can function in an artificial lung until the actual lung becomes available for the patient.
Nawaf Alshammari +2 more
doaj +1 more source
Cis-trans isomerization of peptoid residues in the collagen triple-helix
Nature Communications, 2023 Cis-peptide bonds are rare in proteins, and building blocks less favorable to the trans-conformer have been considered destabilizing. Although proline tolerates the cis-conformer modestly among all amino acids, for collagen, the most prevalent proline ...
Rongmao Qiu +7 more
doaj +1 more source
Peptoid microsphere coatings to improve performance in sandwich ELISA microarrays
Sensing and Bio-Sensing Research, 2021 Enzyme-linked immunosorbent assay (ELISA) microarray performance is limited by low assay sensitivity and dynamic range. Increasing the surface area for reagent binding can help to improve performance, but standard techniques such as roughening the ...
Jesse L. Roberts +2 more
doaj +1 more source
Sequence Changes Modulate Peptoid Self-Association in Water
Frontiers in Chemistry, 2020 Peptoids, N-substituted glycine oligomers, are a class of diverse and sequence-specific peptidomimetics with wide-ranging applications. Advancing the functional repertoire of peptoids to emulate native peptide and protein functions requires engineering ...
Amelia A. Fuller +8 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2022 The synthesis and conformational analysis of the first series of peptoid oligomers composed of consecutive N-(alkylamino)glycine units is investigated. We demonstrate that N-(methylamino)glycine homooligomers can be readily synthesized in solution using ...
Maxime Pypec +3 more
doaj +1 more source
Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters
Frontiers in Chemistry, 2021 Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan +6 more
doaj +1 more source
A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids
Frontiers in Chemistry, 2020 Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy +5 more
doaj +1 more source