Results 11 to 20 of about 3,952 (212)
, 2016 We report the isolation of N-aryl peptoid oligomers that adopt chiral folds, despite the absence of chiral centers. Peptoid monomers incorporating ortho-substituted N-aryl side chains are identified that exhibit axial chirality.
Christian Wolf (385271) +8 more
core +6 more sources
Synthesis and Evaluation of Peptoid-Based Compound Libraries as Inhibitors of Parasite Metallo-Aminopeptidases. [PDF]
ChemMedChemEvaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Aguado ME +16 more
europepmc +2 more sources
Exploring a Ugi-Mediated Polymerization-Induced Self-Assembly Approach to Peptoid Particles. [PDF]
Macromol Rapid CommunUgi‐mediated polymerization‐induced self‐assembly (U‐PISA) enables the one‐pot synthesis of PEG‐stabilized polypeptoid nanoparticles under mild aqueous conditions. By tuning PEG molar mass and feed composition, tunable spherical and worm‐like nano‐objects are obtained.
Nguyen TPT +8 more
europepmc +2 more sources
Pharmaceuticals, 2023 Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens,
Valeria Cafaro +13 more
doaj +1 more source
Peptoid-Functionalized Gold Nanoparticles for Zika Virus Envelope Protein Detection [PDF]
, 2021 Detection and identification of viral pathogens is essential in providing effective and rapid medical treatment. Well-established detection methods can be expensive, slow, and sometimes unable to provide the needed sensitivity and specificity.
Olsen, Meagan
core +3 more sources
Impact of Nanoparticle Size and Surface Chemistry on Peptoid Self-Assembly [PDF]
, 2022 Self-assembled organic nanomaterials can be generated by bottom-up assembly pathways where the structure is controlled by the organic sequence and altered using pH, temperature, and solvation.
Renyu, Zheng +13 more
core +2 more sources
Antimicrobial Peptide-Peptoid Hybrids with and without Membrane Disruption. [PDF]
, 2023 Among synthetic analogues of antimicrobial peptides (AMPs) under investigation to address antimicrobial resistance, peptoids (N-alkylated oligoglycines) have been reported to act both by membrane disruption and on intracellular targets. Here we gradually
Reusser, Jérémie +8 more
core +2 more sources
Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives
Molecules, 2010 Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences.
Rodney J. Ouellette, Adrian S. Culf
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases with irreversible damage of the brain and a continuous pathophysiological process.
Yuxin Guo +6 more
doaj +1 more source
Click mediated synthesis of functionalized glycolipids with peptide-peptoid linkages [PDF]
Journal of the Serbian Chemical Society, 2023 The present work describes the synthesis of a new class of glycolipids with systematic variations in the linkage region, as well as in the aglycon part using Cu(I) catalyzed click reaction.
Singhamahapatra Anadi +5 more
doaj +1 more source