Results 11 to 20 of about 1,730 (178)

Engineering Stealth Properties of Fluorescent Polymeric Nanoparticles by Short‐Chain Polysarcosine

Aggregate
The stealth properties of nanoparticles (NPs) constitute key parameters controlling colloidal stability and nonspecific interactions, which are critical for biological applications.
Tanushree Gupta, Quynh Anh Bui, Horgan Manirakiza, Lina El Hajji, Remi Pelletier, Nicolas Humbert, Abdel Wahab Mouhamad, Andreas Reisch, Arnaud Gautier, Andrey S. Klymchenko   +9 more
doaj   +2 more sources

Data-Driven Engineering of Thermostable Collagen-Mimetic Peptoid Triple Helices. [PDF]

Macromol Rapid Commun
Data‐driven active learning discovery of collagen‐mimetic peptoids capable of forming a thermostable collagen‐like triple helix using computational screening followed by experimental validation. ABSTRACT Collagen‐mimetic peptides (CMPs) are engineered molecules designed to replicate the triple‐helical structure of natural collagen.
Berlaga A, Zheng R, Zhang Z, Lee J, Gandhi D, Chen CL, Ferguson AL.   +6 more
europepmc   +2 more sources

The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid

Pharmaceuticals, 2023
Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens,
Valeria Cafaro, Andrea Bosso, Ilaria Di Nardo, Assunta D’Amato, Irene Izzo, Francesco De Riccardis, Marialuisa Siepi, Rosanna Culurciello, Nunzia D’Urzo, Emiliano Chiarot, Antonina Torre, Elio Pizzo, Marcello Merola, Eugenio Notomista   +13 more
doaj   +1 more source

A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids

Frontiers in Chemistry, 2020
Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy, Mai Shamir, Deborah E. Shalev, Deborah E. Shalev, Mattan Hurevich, Assaf Friedler   +5 more
doaj   +1 more source

Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood

Frontiers in Molecular Neuroscience, 2021
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases with irreversible damage of the brain and a continuous pathophysiological process.
Yuxin Guo, Yuxin Guo, Zhiyuan Hu, Zhiyuan Hu, Zhiyuan Hu, Zhiyuan Hu, Zihua Wang   +6 more
doaj   +1 more source

Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives

Molecules, 2010
Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences.
Rodney J. Ouellette, Adrian S. Culf
doaj   +1 more source

Click mediated synthesis of functionalized glycolipids with peptide-peptoid linkages [PDF]

Journal of the Serbian Chemical Society, 2023
The present work describes the synthesis of a new class of glycolipids with systematic variations in the linkage region, as well as in the aglycon part using Cu(I) catalyzed click reaction.
Singhamahapatra Anadi, Pattnaik Chinmayee, Kar Prasad Bishnu, Nayak Chandra Ganesh, Sahoo Narayan Laxmi, Sahoo Satyanarayan   +5 more
doaj   +1 more source

Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe, Fusobacterium nucleatum

Molecules, 2021
Peptoids (oligo N-substituted glycines) are peptide analogues, which can be designed to mimic host antimicrobial peptides, with the advantage that they are resistant to proteolytic degradation.
Jamie Toole, Hannah L. Bolt, John J. Marley, Sheila Patrick, Steven L. Cobb, Fionnuala T. Lundy   +5 more
doaj   +1 more source

Metalloporphyrin Dimers Bridged by a Peptoid Helix: Host-Guest Interaction and Chiral Recognition

Molecules, 2018
Co-facial porphyrins have been designed to construct porphyrin tweezers with versatile molecular recognition capabilities. In this study, we synthesized metalloporphyrin⁻peptoid conjugates (MPPCs) displaying two metalloporphyrins on a peptoid ...
Yen Jea Lee, Boyeong Kang, Jiwon Seo
doaj   +1 more source

Structure–Function Relationship within Cu-Peptoid Electrocatalysts for Water Oxidation

Inorganics, 2023
Water oxidation (WO) is the first step in the water-splitting process aiming at the production of hydrogen as a green renewable fuel. To successfully perform WO, potent strategies for overcoming the high energetic barrier and slow kinetics of this ...
Guilin Ruan, Natalia Fridman, Galia Maayan   +2 more
doaj   +1 more source