Results 11 to 20 of about 5,562 (217)

Self-Assembly of Minimal Peptoid Sequences [PDF]

ACS Macro Letters, 2020
Peptoids are biofunctional N-substituted glycine peptidomimics. Their self-assembly is of fundamental interest because they demonstrate alternatives to conventional peptide structures based on backbone chirality and beta-sheet hydrogen bonding. The search for self-assembling, water-soluble "minimal" sequences, be they peptide or peptidomimic, is a ...
Castelletto, Valeria, Seitsonen, Jani, Tewari, Kunal M., Hasan, Abshar, Edkins, Robert M., Ruokolainen, Janne, Pandey, Lalit M., Hamley, Ian W., Lau, King Hang Aaron   +9 more
openaire   +10 more sources

Synthesis of Boron-Containing Primary Amines [PDF]

Molecules, 2013
In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate ...
Sheng-Hsuan Chung, Ting-Ju Lin, Qian-Yu Hu, Chia-Hua Tsai, Po-Shen Pan   +4 more
doaj   +4 more sources

Data-Driven Engineering of Thermostable Collagen-Mimetic Peptoid Triple Helices. [PDF]

Macromol Rapid Commun
Data‐driven active learning discovery of collagen‐mimetic peptoids capable of forming a thermostable collagen‐like triple helix using computational screening followed by experimental validation. ABSTRACT Collagen‐mimetic peptides (CMPs) are engineered molecules designed to replicate the triple‐helical structure of natural collagen.
Berlaga A, Zheng R, Zhang Z, Lee J, Gandhi D, Chen CL, Ferguson AL.   +6 more
europepmc   +2 more sources

Sequence Changes Modulate Peptoid Self-Association in Water

Frontiers in Chemistry, 2020
Peptoids, N-substituted glycine oligomers, are a class of diverse and sequence-specific peptidomimetics with wide-ranging applications. Advancing the functional repertoire of peptoids to emulate native peptide and protein functions requires engineering ...
Amelia A. Fuller, Christian J. Jimenez, Ella K. Martinetto, Jose L. Moreno, Anna L. Calkins, Kalli M. Dowell, Jonathan Huber, Kyra N. McComas, Alberto Ortega   +8 more
doaj   +1 more source

First series of N-alkylamino peptoid homooligomers: solution phase synthesis and conformational investigation

Beilstein Journal of Organic Chemistry, 2022
The synthesis and conformational analysis of the first series of peptoid oligomers composed of consecutive N-(alkylamino)glycine units is investigated. We demonstrate that N-(methylamino)glycine homooligomers can be readily synthesized in solution using ...
Maxime Pypec, Laurent Jouffret, Claude Taillefumier, Olivier Roy   +3 more
doaj   +1 more source

Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters

Frontiers in Chemistry, 2021
Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan, Anna Meschkov, Anna Meschkov, Ute Schepers, Ute Schepers, Stefan Bräse, Stefan Bräse   +6 more
doaj   +1 more source

The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid

Pharmaceuticals, 2023
Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens,
Valeria Cafaro, Andrea Bosso, Ilaria Di Nardo, Assunta D’Amato, Irene Izzo, Francesco De Riccardis, Marialuisa Siepi, Rosanna Culurciello, Nunzia D’Urzo, Emiliano Chiarot, Antonina Torre, Elio Pizzo, Marcello Merola, Eugenio Notomista   +13 more
doaj   +1 more source

Peptomer Linkers Enable Kinetic Control over Co-Delivery of Multiple Chemotherapeutics. [PDF]

Adv Healthc Mater
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Watkins CM, Hallam SL, Austin MJ, Rosales AM.   +3 more
europepmc   +2 more sources

Chain-end modifications and sequence arrangements of antimicrobial peptoids for mediating activity and nano-assembly [PDF]

, 2020
Poly(N-substituted glycine) “peptoids” are an interesting class of peptidomimics that can resist proteolysis and mimic naturally found antimicrobial peptides (AMPs), which exhibit wide spectrum activity against bacteria.
Castelletto, Valeria, Hamley, Ian W., Hasan, Abshar, Lau, King Hang Aaron, Pandey, Lalit M., Ruokolainen, Janne, Saxena, Varun, Sefcik, Jan, Seitsonen, Jani, Zimbitas, Georgina   +9 more
core   +2 more sources

A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids

Frontiers in Chemistry, 2020
Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy, Mai Shamir, Deborah E. Shalev, Deborah E. Shalev, Mattan Hurevich, Assaf Friedler   +5 more
doaj   +1 more source