Results 31 to 40 of about 3,952 (212)
Membrane‐acting biomimetic peptoids against visceral leishmaniasis
FEBS Open Bio, 2023 Visceral leishmaniasis (VL) is among the most neglected tropical diseases in the world. Drug cell permeability is essential for killing the intracellular residing parasites responsible for VL, making cell‐permeating peptides a logical choice to address ...
Vivek Kumar +8 more
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Antioxidants, 2023 Copper is an essential metal ion that is involved in critical cellular processes, but which can also exhibit toxic effects through its ability to catalyze reactive oxygen species (ROS) formation. Dysregulation of copper homeostasis has been implicated in
Anastasia Esther Behar, Galia Maayan
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Pharmaceuticals, 2012 Cell penetrating peptoids (CPPos) are potent mimics of the corresponding cell penetrating peptides (CPPs). The synthesis of diverse oligomeric libraries that display a variety of backbone scaffolds and side-chain appendages are a very promising source of
Dominik K. Kölmel +6 more
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Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells. [PDF]
PLoS ONE, 2016 The in situ detection of caspase-3 activity has applications in the imaging and monitoring of multiple pathologies, notably cancer. A series of cell penetrating FRET-based fluorogenic substrates were designed and synthesised for the detection of caspase ...
Ana M Pérez-López +4 more
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Molecules, 2023 Nanotechnology has assumed a significant role over the last decade in the development of various technologies applied to health sciences. This becomes even more evident with its application in controlled drug delivery systems.
Thaissa Pasquali F. Rosalba +3 more
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Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides
Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi +8 more
wiley +2 more sources
Synthesis of Boron-Containing Primary Amines
Molecules, 2013 In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate ...
Sheng-Hsuan Chung +4 more
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Antifouling Peptoid Biointerfaces
, 2020 Recent advances in synthetic chemistry has led to the increasingly sophisticated design and preparation of biofunctional polymeric surfaces and materials. In this regard, synthetic poly-(N-substituted glycine) “peptoids” which mimic the structure and function of peptides play an important role, since they may attain functionalities similar to natural ...
Saxena, Varun +2 more
openaire +2 more sources
Peptoids for biomaterials science [PDF]
Biomater. Sci., 2014 Reports of peptoid structures and interfaces highlighting their potential as synthetically convenient, multifunctional, modular and precisely tunable biomaterials are reviewed.
openaire +4 more sources
Addressing MRSA infection and antibacterial resistance with peptoid polymers
Nature Communications, 2021 Antibiotic resistance is a major issue in medicine and new antimicrobials for treating resistant infection are needed. Here, the authors report on antibacterial peptoid polymers, prepared via NNCA ring-opening polymerization, demonstrating antibacterial ...
Jiayang Xie +15 more
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