Results 31 to 40 of about 5,562 (217)

Structure–Function Relationship within Cu-Peptoid Electrocatalysts for Water Oxidation

Inorganics, 2023
Water oxidation (WO) is the first step in the water-splitting process aiming at the production of hydrogen as a green renewable fuel. To successfully perform WO, potent strategies for overcoming the high energetic barrier and slow kinetics of this ...
Guilin Ruan, Natalia Fridman, Galia Maayan   +2 more
doaj   +1 more source

Antifouling Glycocalyx-Mimetic Peptoids [PDF]

Journal of the American Chemical Society, 2013
The glycocalyx of the cell is composed of highly hydrated saccharidic groups conjugated to protein and lipid cores. Although components of the glycocalyx are important in cell-cell interactions and other specific biological recognition events, a fundamental role of the glycocalyx is the inhibition of nonspecific interactions at the cell surface ...
Ham, Hyun Ok, Park, Sung Hyun, Kurutz, Josh W, Szleifer, Igal G, Messersmith, Phillip B   +4 more
openaire   +4 more sources

Ultra-Short Antimicrobial Peptoids Show Propensity for Membrane Activity Against Multi-Drug Resistant Mycobacterium tuberculosis

Frontiers in Microbiology, 2020
Tuberculosis (TB) results in both morbidity and mortality on a global scale. With drug resistance on the increase, there is an urgent need to develop novel anti-mycobacterials.
Jasmeet Singh Khara, Jasmeet Singh Khara, Biljana Mojsoska, Devika Mukherjee, Paul R. Langford, Brian D. Robertson, Håvard Jenssen, Pui Lai Rachel Ee, Sandra M. Newton   +8 more
doaj   +1 more source

Peptides blocking ApoE pathological function safely reduce pathology in TgSwDI/apoE2, 3 and 4 AD mice [PDF]

Alzheimers Dement
Abstract Background We previously demonstrated that a peptoid (LPFFA) prevents Aβ binding to human apoE producing cognitive rescue and reduced Aβ pathology on AD mouse models. We have now developed specific peptides that disrupt α‐helices essential for apoE conformation and pathological function; and tested, in cerebral amyloid angiopathy (CAA) TgSwDI ...
Goni F, Wang D, Suazo J, Lin J, Okeagu J, Gamallo‐Lana B, Mar A, Wisniewski T.   +7 more
europepmc   +2 more sources

Poly-Sarcosine and Poly(ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations [PDF]

, 2018
Nanoparticles coated with hydrophilic polymers often show a reduction in unspecific interactions with the biological environment, which improves their biocompatibility.
Barz, Matthias, Muhl, Christian, Schmid, Friederike, Schäfer, Timo, Settanni, Giovanni   +4 more
core   +3 more sources

A peptoid interleukin‐15 receptor antagonist suppresses inflammation and arthritis in mice

Clinical & Translational Immunology, 2022
Objective To discover a novel peptoid antagonist that targets the interleukin‐15 (IL‐15) receptor and to evaluate its therapeutic efficacy in the treatment of inflammation and arthritis. Methods A new compound (IFRA3, interleukin‐15 receptor antagonist 3)
Kwang Bog Cho, Satya Prakash Shukla, Maheshkumar Kannan, Haowen Zhang, Sundus Jabeen Amina, Shuang Zhou, Yanping Chen, Jeremiah F Molligan, Veena Taneja, Chandra Mohan, D Gomika Udugamasooriya, Bin Guo   +11 more
doaj   +1 more source

Cyclic β-Peptoids

Organic Letters, 2008
The first synthesis of functionalized -peptoid macrocycles is reported. X-ray crystallographic structure of tetramer 9 reveals a C2-symmetrical derivative with unexpected all-cis-amide bonds and spatial disposition of the appendages toward the two opposite faces of the ring. Quantum calculations suggest that 9 is locked in this layout.
Roy, Olivier, Faure, Sophie, Thery, Vincent, Didierjean, C., Taillefumier, Claude   +4 more
openaire   +2 more sources

Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds [PDF]

, 2015
β-Peptoids are peptidomimetics based on N-alkylated β-aminopropionic acid residues (or N-alkyl-β-alanines). This type of peptide mimic has previously been incorporated in biologically active ligands and has been hypothesized to be able to exhibit ...
Fristrup, Peter, Harris, Pernille, Laursen, Jonas Striegler, Olsen, Christian Adam   +3 more
core   +1 more source

Direct Selection of Functional De Novo Macrocycles for Activation of On‐Cellulo Insulin Receptor

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
A live‐cell screening platform, RaPID‐ExCells, integrates mRNA display‐derived macrocyclic peptide libraries with functional selection against native cell‐surface receptors. Application to the insulin receptor enabled de novo discovery of a macrocyclic agonist that activates endogenous signaling despite weak in vitro binding, highlighting the power of ...
Yun‐Hsuan Kuo, Emiko Mihara, Junichi Takagi, Hiroaki Suga   +3 more
wiley   +2 more sources

In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

Molecules, 2018
Antimicrobial peptides (AMPs) hold promise as the next generation of antimicrobial agents, but often suffer from rapid degradation in vivo. Modifying AMPs with non-proteinogenic residues such as peptoids (oligomers of N-alkylglycines) provides the ...
Ines Greco, Bernard D. Hummel, Jaspreet Vasir, Jeffrey L. Watts, Jason Koch, Johannes E. Hansen, Hanne Mørck Nielsen, Peter Damborg, Paul R. Hansen   +8 more
doaj   +1 more source