Results 31 to 40 of about 1,730 (178)
Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells. [PDF]
PLoS ONE, 2016 The in situ detection of caspase-3 activity has applications in the imaging and monitoring of multiple pathologies, notably cancer. A series of cell penetrating FRET-based fluorogenic substrates were designed and synthesised for the detection of caspase ...
Ana M Pérez-López +4 more
doaj +1 more source
Molecules, 2023 Nanotechnology has assumed a significant role over the last decade in the development of various technologies applied to health sciences. This becomes even more evident with its application in controlled drug delivery systems.
Thaissa Pasquali F. Rosalba +3 more
doaj +1 more source
Synthesis of Boron-Containing Primary Amines
Molecules, 2013 In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate ...
Sheng-Hsuan Chung +4 more
doaj +1 more source
Addressing MRSA infection and antibacterial resistance with peptoid polymers
Nature Communications, 2021 Antibiotic resistance is a major issue in medicine and new antimicrobials for treating resistant infection are needed. Here, the authors report on antibacterial peptoid polymers, prepared via NNCA ring-opening polymerization, demonstrating antibacterial ...
Jiayang Xie +15 more
doaj +1 more source
Antifouling Peptoid Biointerfaces
, 2020 Recent advances in synthetic chemistry has led to the increasingly sophisticated design and preparation of biofunctional polymeric surfaces and materials. In this regard, synthetic poly-(N-substituted glycine) “peptoids” which mimic the structure and function of peptides play an important role, since they may attain functionalities similar to natural ...
Saxena, Varun +2 more
openaire +2 more sources
Molecules, 2019 Methicillin-resistant Staphylococcus pseudintermedius (MRSP) constitutes an emerging health problem for companion animals in veterinary medicine. Therefore, discovery of novel antimicrobial agents for treatment of Staphylococcus-associated canine ...
Ines Greco +8 more
doaj +1 more source
Peptoids for biomaterials science [PDF]
Biomater. Sci., 2014 Reports of peptoid structures and interfaces highlighting their potential as synthetically convenient, multifunctional, modular and precisely tunable biomaterials are reviewed.
openaire +4 more sources
Direct Selection of Functional De Novo Macrocycles for Activation of On‐Cellulo Insulin Receptor
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.A live‐cell screening platform, RaPID‐ExCells, integrates mRNA display‐derived macrocyclic peptide libraries with functional selection against native cell‐surface receptors. Application to the insulin receptor enabled de novo discovery of a macrocyclic agonist that activates endogenous signaling despite weak in vitro binding, highlighting the power of ...
Yun‐Hsuan Kuo +3 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2012 Two syntheses of natural viridic acid, an unusual triply N-methylated peptide with two anthranilate units, are presented. The first one is based on peptide-coupling strategies and affords the optically active natural product in 20% overall yield over six
Ricardo A. W. Neves Filho +3 more
doaj +1 more source
Organic Letters, 2008 The first synthesis of functionalized -peptoid macrocycles is reported. X-ray crystallographic structure of tetramer 9 reveals a C2-symmetrical derivative with unexpected all-cis-amide bonds and spatial disposition of the appendages toward the two opposite faces of the ring. Quantum calculations suggest that 9 is locked in this layout.
Roy, Olivier +4 more
openaire +2 more sources