Results 1 to 10 of about 2,483,636 (309)
SynOpen, 2022 We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of ...
Mojtaba Ayoubi +5 more
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Adjuvant DNA vaccine pNMM promotes enhanced specific immunity and anti-tumor effects
Human Vaccines & Immunotherapeutics, 2023 DNA vaccines containing only antigenic components have limited efficacy and may fail to induce effective immune responses. Consequently, adjuvant molecules are often added to enhance immunogenicity.
Yu Wang +12 more
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Total wash elimination for solid phase peptide synthesis
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
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Peptide Vaccines in Melanoma: Chemical Approaches towards Improved Immunotherapeutic Efficacy
Pharmaceutics, 2023 Cancer of the skin is by far the most common of all cancers. Although the incidence of melanoma is relatively low among skin cancers, it can account for a high number of skin cancer deaths.
Beáta Biri-Kovács +3 more
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Communications Biology, 2021 Zhang et al. use mouse tumor models to show that the optimum treatment regime for Treg-induced radiation resistance is vaccine administration followed by radiation therapy.
Fayun Zhang +10 more
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Activation of the adipocyte CREB/CRTC pathway in obesity
Communications Biology, 2021 Yoon et al show that a high fat diet in mice activates the CREB/CRTC pathway in adipocytes by decreasing the expression of Salt Inducible Kinase 2 (SIK2), a Ser/Thr kinase that otherwise phosphorylates and sequesters CREB coactivators in the cytoplasm ...
Young-Sil Yoon +6 more
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Evaluation of a PACAP Peptide Analogue Labeled with (68)Ga Using Two Different Chelating Agents. [PDF]
, 2016 OBJECTIVE: The authors have conjugated chelating agents (DOTA and NODAGA) with a peptide (pituitary adenylate cyclase-activating peptide [PACAP] analogue) that has a high affinity for VPAC1 receptors expressed on cancer cells.
Chen, Chang-Po +6 more
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Introduction of d-Glutamate at a Critical Residue of Aβ42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity. [PDF]
, 2016 The amyloid beta peptide 42 (Aβ42) is an aggregation-prone peptide that plays a pivotal role in Alzheimer's disease. We report that a subtle perturbation to the peptide through a single chirality change at glutamate 22 leads to a pronounced delay in the ...
Dutta, Subrata +3 more
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Quantifying systemic molecular networks affected during high altitude de-acclimatization
Scientific Reports, 2023 High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on either understanding and ameliorating high altitude disease or finding better ...
Subhojit Paul +5 more
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Peptide-Gold Nanoparticle Conjugates as Artificial Carbonic Anhydrase Mimics [PDF]
, 2019 We herein describe the design and synthesis of a catalytically active peptide–gold nanoparticle conjugate (Pep-Au-NP) that binds Zn(II) within its peptide monolayer and develops carbonic anhydrase activity. Specifically, a modified variant of the β-sheet
Koksch, Beate, Mikolajczak, Dorian J.
core +1 more source