Results 21 to 30 of about 2,483,636 (309)

Dimensionality of Carbon Nanomaterials Determines the Binding and Dynamics of Amyloidogenic Peptides: Multiscale Theoretical Simulations [PDF]

, 2013
Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and ...
A Albanese, A de Leon, A Gajewicz, A Hung, A Hung, A Hung, A Hung, A Hung, AA Mostofi, AA Shvedova, Ad Leon, Adam J. Makarucha, AJ Makarucha, AK Chamberlain, Arash A. Mostofi, AV Ghule, B Hess, B Roux, C Cabaleiro-Lago, C Li, C-K Skylaris, CA MacRaild, CA MacRaild, CC Chiu, CC Chiu, CK Skylaris, CK Skylaris, CL Teoh, D Frishman, D Van Der Spoel, DJ Cole, DM Hatters, EE Oren, G Lever, G Zuo, G Zuo, G Zuo, GB McGaughey, H Li, HC Fischer, HJC Berendsen, Irene Yarovsky, J Antony, J Dziedzic, J Kayat, J Lee, James M. Briggs, JP Perdew, JP Segrest, LJ Liang, LK Vesterdal, LM Wilson, LP Lee, M Mahmoudi, M Mahmoudi, M van der Zande, M Zhang, M Zhu, MDW Griffin, MP Monopoli, N Todorova, N Todorova, N Todorova, NDM Hine, Nevena Todorova, Nicholas D. M. Hine, Q Hill, Q Sun, R Cukalevski, R de la Rica, R Mout, RS D'Rozario, S De Miranda Tomásio, S Ehrlich, S Linse, SA Andujar, SA Love, SM Tomasio, ST Yang, TE Cheatham, TR Walsh, VC Sanchez, VL Colvin, VZ Poenitzsch, W Humphrey, WH Noon, Z Fu, Z Li, Z Yang   +88 more
core   +9 more sources

Matrix stiffness affects endocytic uptake of MK2-inhibitor peptides. [PDF]

, 2013
In this study, the role of substrate stiffness on the endocytic uptake of a cell-penetrating peptide was investigated. The cell-penetrating peptide, an inhibitor of mitogen-activated protein kinase activated protein kinase II (MK2), enters a primary ...
Brugnano, Jamie L, Panitch, Alyssa
core   +6 more sources

Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy

Journal of Hematology & Oncology, 2018
Background The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer.
Erhao Zhang, Peiwei Yang, Jieyi Gu, Heming Wu, Xiaowei Chi, Chen Liu, Ying Wang, Jianpeng Xue, Weiyan Qi, Qingbo Sun, Shengnan Zhang, Jialiang Hu, Hanmei Xu   +12 more
doaj   +1 more source

N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19

Advances in Pharmacological and Pharmaceutical Sciences, 2022
The airway epithelial glycocalyx plays an important role in preventing severe acute respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial glycocalyx contributes to vascular permeability and tone, as well as modulating ...
Heidi N du Preez, Colleen Aldous, Hendrik G Kruger, Lin Johnson   +3 more
doaj   +1 more source

Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure [PDF]

, 2014
BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments.
Barton, P, Dries, DL, Felkin, LE, Lee, R, Rame, JE, Xu, B   +5 more
core   +1 more source

PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer

Breast Cancer Research, 2023
Background Radiotherapy is widely applied in breast cancer treatment, while radiotherapy resistance is inevitable. TGF-β1 has been considered to be an endogenous factor for the development of radiotherapy resistance.
Fayun Zhang, Zifeng Zheng, Luoyang Wang, Wenfeng Zeng, Wenjing Wei, Chunling Zhang, Ziran Zhao, Wei Liang   +7 more
doaj   +1 more source

The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation [PDF]

, 2009
Objective—The activation of nuclear factor-kB (NF-kB) is a crucial step in the arterial wall’s response to injury. The identification and characterization of the NF-kB essential modulator– binding domain (NBD) peptide, which can block the activation of
Carnuccio, R., De Stefano, D., Di Lauro, M.V., Di Meglio, P., Grassia, G., Ialenti, A., Ianaro, A., Kennedy, S., Maddaluno, M., Maffia, P., Musilli, C., Parenti, A., Parratt, C.A.   +12 more
core   +1 more source

Peptide Bioinformatics- Peptide Classification Using Peptide Machines [PDF]

, 2008
Peptides scanned from whole protein sequences are the core information for many peptide bioinformatics research such as functional site prediction, protein structure identification, and protein function recognition. In these applications, we normally need to assign a peptide to one of the given categories using a computer model.
openaire   +2 more sources

Preferred Configurations of Peptide–Peptide Interactions

The Journal of Physical Chemistry A, 2013
The natural and fundamental proclivities of interaction between a pair of peptide units are examined using high-level ab initio calculations. The NH···O H-bonded structure is found to be the most stable configuration of the N-methylacetamide (NMA) model dimer, but only slightly more so than a stacked arrangement.
Adhikari, U., Scheiner, Steve
openaire   +5 more sources

Antibacterial Peptides [PDF]

Antibiotics, 2020
As natural host defense compounds produced by numerous prokaryotic and eukaryotic life forms, antimicrobial peptides (AMPs) are now emerging as solid candidate chemotherapeutic drugs to fight against the various types of pathogenic Gram-positive and Gram-negative bacteria, especially those resistant to current antibiotics [...]
openaire   +4 more sources