Results 11 to 20 of about 1,445,844 (265)

Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy

Journal of Hematology & Oncology, 2018
Background The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer.
Erhao Zhang, Peiwei Yang, Jieyi Gu, Heming Wu, Xiaowei Chi, Chen Liu, Ying Wang, Jianpeng Xue, Weiyan Qi, Qingbo Sun, Shengnan Zhang, Jialiang Hu, Hanmei Xu   +12 more
doaj   +1 more source

CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity

Advanced Science, 2022
The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with
Hongxia Duan, Lin Jing, Jianquan Xiang, Chenhui Ju, Zhenzhen Wu, Jingyu Liu, Xinran Ma, Xuehui Chen, Zheng Liu, Jing Feng, Xiyun Yan   +10 more
doaj   +1 more source

C-peptide is a bioactive peptide [PDF]

Diabetologia, 2007
-ATPase.Nerveconductionvelocity.RedbloodcelldeformabilityAbbreviationsBB/Wor BioBreeding/WorcestereNOS endothelial nitric oxide synthaseICAM-1 intracellular adhesion molecule 1MAPK mitogen-activated protein kinaseNCV nerve conduction velocityDuring the past decade, reports from several laboratorieshave focused on the physiological effects of C-peptide ...
J, Wahren, K, Ekberg, H, Jörnvall
openaire   +2 more sources

Crystal structure of methyl 1-(2-(fluorosulfonyl)ethyl)-2-oxocyclopentanecarboxylate, C9H13FO5S

Zeitschrift für Kristallographie - New Crystal Structures, 2017
C9H13FO5S, triclinic, P1̅ (no. 2), a = 5.9390(3) Å, b = 8.1581(4) Å, c = 11.3823(8) Å, α = 89.498(3)°, β = 85.314(5)°, γ = 84.916(5)°, V = 547.48(5) Å3, Z = 2, Rgt(F) = 0.0303, wRref(F2) = 0.0811, T = 293 K.
Govender Kimberleigh B., Samipillai Marivel, Govender Thavendran, Kruger Hendrik G., Naicker Tricia   +4 more
doaj   +1 more source

Crystal structure of (E)-2-(4-cyanophenyl)ethenesulfonyl fluoride, C9H6FNO2S

Zeitschrift für Kristallographie - New Crystal Structures, 2019
C9H6FNO2S, triclinic, P1̄ (no. 2), a = 7.2786(2) Å, b = 8.1014(3) Å, c = 16.1084(5) Å, α = 76.320(1)°, β = 87.918(1)°, γ = 80.784(1)°, V = 911.00(5) Å3, Z = 4, Rgt(F) = 0.0298, wRref(F2) = 0.0857, T = 100(2) K.
Brasil Edikarlos, Samipillai Marivel, Govender Thavendran, Kruger Hendrik G., Naicker Tricia   +4 more
doaj   +1 more source

PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer

Breast Cancer Research, 2023
Background Radiotherapy is widely applied in breast cancer treatment, while radiotherapy resistance is inevitable. TGF-β1 has been considered to be an endogenous factor for the development of radiotherapy resistance.
Fayun Zhang, Zifeng Zheng, Luoyang Wang, Wenfeng Zeng, Wenjing Wei, Chunling Zhang, Ziran Zhao, Wei Liang   +7 more
doaj   +1 more source

Cyclic homodimer formation by singlet oxygen-mediated oxidation of carnosine

Frontiers in Chemistry
Although carnosine (β-Ala-L-His) is one of physiological protectants against in vivo damages caused by reactive oxygen species (ROS), its reactivity against singlet oxygen (1O2), an ROS, is still unclear at the molecular level.
Hiroko Kawakami, Hiroko Kawakami, Yuki Itakura, Tetsuya Yamamoto, Taku Yoshiya, Taku Yoshiya   +5 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors

Antibiotics, 2023
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy, Letisha Girdhari, Mbongeni Shungube, Arnoldus C. Gouws, Byron K. Peters, Kamal K. Rajbongshi, Sooraj Baijnath, Sipho Mdanda, Thandokuhle Ntombela, Thilona Arumugam, Linda A. Bester, Sanil D. Singh, Anil Chuturgoon, Per I. Arvidsson, Glenn E. M Maguire, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker   +17 more
doaj   +1 more source

Peptides, Antibodies, Peptide Antibodies and More [PDF]

International Journal of Molecular Sciences, 2019
The applications of peptides and antibodies to multiple targets have emerged as powerful tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are unique since they, in theory, can be directed to any desired target, which illustrates their versatile nature and broad spectrum of use as illustrated by numerous applications of ...
Nicole Trier, Paul Hansen, Gunnar Houen
openaire   +3 more sources