Results 21 to 30 of about 1,730 (178)

Ultra-Short Antimicrobial Peptoids Show Propensity for Membrane Activity Against Multi-Drug Resistant Mycobacterium tuberculosis

Frontiers in Microbiology, 2020
Tuberculosis (TB) results in both morbidity and mortality on a global scale. With drug resistance on the increase, there is an urgent need to develop novel anti-mycobacterials.
Jasmeet Singh Khara, Jasmeet Singh Khara, Biljana Mojsoska, Devika Mukherjee, Paul R. Langford, Brian D. Robertson, Håvard Jenssen, Pui Lai Rachel Ee, Sandra M. Newton   +8 more
doaj   +1 more source

Peptomer Linkers Enable Kinetic Control over Co-Delivery of Multiple Chemotherapeutics. [PDF]

Adv Healthc Mater
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Watkins CM, Hallam SL, Austin MJ, Rosales AM.   +3 more
europepmc   +2 more sources

Uprising Unconventional Nanobiomaterials: Peptoid Nanosheets as a Multi‐Modular Platform for Advanced Biological Studies [PDF]

Small
Biljana Mojsoska
exaly   +2 more sources

A peptoid interleukin‐15 receptor antagonist suppresses inflammation and arthritis in mice

Clinical & Translational Immunology, 2022
Objective To discover a novel peptoid antagonist that targets the interleukin‐15 (IL‐15) receptor and to evaluate its therapeutic efficacy in the treatment of inflammation and arthritis. Methods A new compound (IFRA3, interleukin‐15 receptor antagonist 3)
Kwang Bog Cho, Satya Prakash Shukla, Maheshkumar Kannan, Haowen Zhang, Sundus Jabeen Amina, Shuang Zhou, Yanping Chen, Jeremiah F Molligan, Veena Taneja, Chandra Mohan, D Gomika Udugamasooriya, Bin Guo   +11 more
doaj   +1 more source

In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

Molecules, 2018
Antimicrobial peptides (AMPs) hold promise as the next generation of antimicrobial agents, but often suffer from rapid degradation in vivo. Modifying AMPs with non-proteinogenic residues such as peptoids (oligomers of N-alkylglycines) provides the ...
Ines Greco, Bernard D. Hummel, Jaspreet Vasir, Jeffrey L. Watts, Jason Koch, Johannes E. Hansen, Hanne Mørck Nielsen, Peter Damborg, Paul R. Hansen   +8 more
doaj   +1 more source

Synthesis of Novel Steroid-Peptoid Hybrid Macrocycles by Multiple Multicomponent Macrocyclizations Including Bifunctional Building Blocks (MiBs)

Molecules, 2007
Two new groups of cholane-peptoid hybrid macrocycles were produced by implementing novel combinations of the MiB methodology. Steroid-based hybrid macrolactams including heterocycle and aryl moieties were obtained by utilizing cholanic dicarboxylic acids
Ludger A. Wessjohann, Daniel G. Rivera
doaj   +1 more source

Review: Structure-Activity Relationship of Antimicrobial Peptoids

Pharmaceutics, 2023
Due to their broad-spectrum activity against Gram-negative and Gram-positive bacteria, natural antimicrobial peptides (AMPs) and their synthetic analogs have emerged as prospective therapies for treating illnesses brought on by multi-drug resistant ...
Priscilla L. Nyembe, Thandokuhle Ntombela, Maya M. Makatini   +2 more
doaj   +1 more source

Membrane‐acting biomimetic peptoids against visceral leishmaniasis

FEBS Open Bio, 2023
Visceral leishmaniasis (VL) is among the most neglected tropical diseases in the world. Drug cell permeability is essential for killing the intracellular residing parasites responsible for VL, making cell‐permeating peptides a logical choice to address ...
Vivek Kumar, Jennifer S. Lin, Natalia Molchanova, John A. Fortkort, Carolin Reckmann, Stefan Bräse, Håvard Jenssen, Annelise E. Barron, Archana Chugh   +8 more
doaj   +1 more source

A Peptoid-Chelator Selective to Cu²⁺ That Can Extract Copper from Metallothionein-2 and Lead to the Production of ROS

Antioxidants, 2023
Copper is an essential metal ion that is involved in critical cellular processes, but which can also exhibit toxic effects through its ability to catalyze reactive oxygen species (ROS) formation. Dysregulation of copper homeostasis has been implicated in
Anastasia Esther Behar, Galia Maayan
doaj   +1 more source

Cell Penetrating Peptoids (CPPos): Synthesis of a Small Combinatorial Library by Using IRORI MiniKans

Pharmaceuticals, 2012
Cell penetrating peptoids (CPPos) are potent mimics of the corresponding cell penetrating peptides (CPPs). The synthesis of diverse oligomeric libraries that display a variety of backbone scaffolds and side-chain appendages are a very promising source of
Dominik K. Kölmel, Daniel Fürniss, Steven Susanto, Andrea Lauer, Clemens Grabher, Stefan Bräse, Ute Schepers   +6 more
doaj   +1 more source