Results 41 to 50 of about 5,562 (217)

Synthesis of Novel Steroid-Peptoid Hybrid Macrocycles by Multiple Multicomponent Macrocyclizations Including Bifunctional Building Blocks (MiBs)

Molecules, 2007
Two new groups of cholane-peptoid hybrid macrocycles were produced by implementing novel combinations of the MiB methodology. Steroid-based hybrid macrolactams including heterocycle and aryl moieties were obtained by utilizing cholanic dicarboxylic acids
Ludger A. Wessjohann, Daniel G. Rivera
doaj   +1 more source

Review: Structure-Activity Relationship of Antimicrobial Peptoids

Pharmaceutics, 2023
Due to their broad-spectrum activity against Gram-negative and Gram-positive bacteria, natural antimicrobial peptides (AMPs) and their synthetic analogs have emerged as prospective therapies for treating illnesses brought on by multi-drug resistant ...
Priscilla L. Nyembe, Thandokuhle Ntombela, Maya M. Makatini   +2 more
doaj   +1 more source

Membrane‐acting biomimetic peptoids against visceral leishmaniasis

FEBS Open Bio, 2023
Visceral leishmaniasis (VL) is among the most neglected tropical diseases in the world. Drug cell permeability is essential for killing the intracellular residing parasites responsible for VL, making cell‐permeating peptides a logical choice to address ...
Vivek Kumar, Jennifer S. Lin, Natalia Molchanova, John A. Fortkort, Carolin Reckmann, Stefan Bräse, Håvard Jenssen, Annelise E. Barron, Archana Chugh   +8 more
doaj   +1 more source

A Peptoid-Chelator Selective to Cu²⁺ That Can Extract Copper from Metallothionein-2 and Lead to the Production of ROS

Antioxidants, 2023
Copper is an essential metal ion that is involved in critical cellular processes, but which can also exhibit toxic effects through its ability to catalyze reactive oxygen species (ROS) formation. Dysregulation of copper homeostasis has been implicated in
Anastasia Esther Behar, Galia Maayan
doaj   +1 more source

Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study [PDF]

, 2016
We describe the qualitative and quantitative analysis of the complexation properties towards cations of a cyclic peptoid hexamer composed of alternating α- and β-peptoid monomers, which bear exclusively chiral (S)-phenylethyl side chains (spe) that have ...
A. A. Edwards, A.-S. Biesse-Martin, Armand, Arnaud-Neu, B. D. Alexander, B. V. Nielsen, Baskin, Baskin, Baskin, Bosque-Sendra, C. Taillefumier, Caumes, Conti, Culf, Culf, D. Mistry, Daily, De Cola, De Cola, De Santis, De Santis, Della Sala, Devarajan, Diamond, Dudek, Durán Merás, E. De Santis, Eberspaecher, G. Siligardi, Gorske, Goutelle, Han, Hinaje, Hioki, Hjelmgaard, Izzo, Javorfi, Kalugin, Kelly, Kirshenbaum, Knight, Knight, L. Waters, Lee, Maayan, Maayan, Maharani, Maulucci, Mishustin, Ovchinnikov, Pigot, R. Hussain, Roy, S. Faure, S. J. Holder, Schettini, Shannon, Shin, Siligardi, Siligardi, Stewart, Sui, Wu, Wu, Yoe, Yoo, Zabrodski, Zeng, Zsila   +68 more
core   +2 more sources

Cell Penetrating Peptoids (CPPos): Synthesis of a Small Combinatorial Library by Using IRORI MiniKans

Pharmaceuticals, 2012
Cell penetrating peptoids (CPPos) are potent mimics of the corresponding cell penetrating peptides (CPPs). The synthesis of diverse oligomeric libraries that display a variety of backbone scaffolds and side-chain appendages are a very promising source of
Dominik K. Kölmel, Daniel Fürniss, Steven Susanto, Andrea Lauer, Clemens Grabher, Stefan Bräse, Ute Schepers   +6 more
doaj   +1 more source

Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells. [PDF]

PLoS ONE, 2016
The in situ detection of caspase-3 activity has applications in the imaging and monitoring of multiple pathologies, notably cancer. A series of cell penetrating FRET-based fluorogenic substrates were designed and synthesised for the detection of caspase ...
Ana M Pérez-López, M Lourdes Soria-Gila, Emma R Marsden, Annamaria Lilienkampf, Mark Bradley   +4 more
doaj   +1 more source

Rational Design and Multicomponent Synthesis of Lipid–Peptoid Nanocomposites towards a Customized Drug Delivery System Assembly

Molecules, 2023
Nanotechnology has assumed a significant role over the last decade in the development of various technologies applied to health sciences. This becomes even more evident with its application in controlled drug delivery systems.
Thaissa Pasquali F. Rosalba, Guilherme D. R. Matos, Carlos Eduardo M. Salvador, Carlos Kleber Z. Andrade   +3 more
doaj   +1 more source

The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus [PDF]

, 2013
BACKGROUND: The increase in antibiotic resistant bacteria has led to renewed interest in development of alternative antimicrobial compounds such as antimicrobial peptides (AMPs), either naturally-occurring or synthetically-derived.
Cohn, Marianne T, Gottlieb, Caroline Trebbien, Gottschalk, Sanne, Gram, Lone, Hansen, Paul R., Hiasa, Hiroshi, Ifrah, Dan, Ingmer, Hanne, Lerche, Sandra, Thomsen, Line Elnif   +9 more
core   +1 more source

Peptoids for biomaterials science [PDF]

Biomater. Sci., 2014
Reports of peptoid structures and interfaces highlighting their potential as synthetically convenient, multifunctional, modular and precisely tunable biomaterials are reviewed.
openaire   +3 more sources