Results 61 to 70 of about 1,730 (178)
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
Antiviral Effect of Antimicrobial Peptoid TM9 and Murine Model of Respiratory Coronavirus Infection
PharmaceuticsNew antiviral agents are essential to improving treatment and control of SARS-CoV-2 infections that can lead to the disease COVID-19. Antimicrobial peptoids are sequence-specific oligo-N-substituted glycine peptidomimetics that emulate the structure and ...
Maxim Lebedev +8 more
doaj +1 more source
Functionalized Surface Coatings for Rigid Contact Lenses
Journal of Functional BiomaterialsThis research evolves into a comparative study of three different phenolic composites as coatings for rigid contact lenses, with a particular emphasis on enhancing their antifouling properties and hydrophobicity.
Roeya Refaei +8 more
doaj +1 more source
Advanced Sensor Research, Volume 5, Issue 3, March 2026.ABSTRACT Profluorescent nitroxides (PFNs) have established themselves as powerful tools for monitoring oxidative processes and subcellular redox dynamics by reactive oxygen species (ROS). Their characteristic “off–on” behavior arises from the efficient, proximity‐driven quenching of covalently bound fluorophores by paramagnetic nitroxide radicals ...
Haider N. Sultani +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding +5 more
wiley +1 more source
Protein Structure Determination by Racemic and Quasi‐Racemic X‐Ray Crystallography
ChemBioChem, Volume 27, Issue 4, 25 February 2026.Racemic mixtures of protein enantiomers facilitate formation of diffraction‐quality crystals in centrosymmetric space groups that have quantized phases which simplify structure solution. Quasi‐racemic mixtures of a protein and its mirror image isomorph similarly facilitate formation of highly ordered crystals.
Stephen B. H. Kent
wiley +1 more source
Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity.
PLoS ONE, 2014 Cationic, amphipathic host defense peptides represent a promising group of agents to be developed for anticancer applications. Poly-N-substituted glycines, or peptoids, are a class of biostable, peptidomimetic scaffold that can display a great diversity ...
Wei Huang +6 more
doaj +1 more source
Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
Nature Communications, 2018 Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt ...
Jeffrey A. Schneider +12 more
doaj +1 more source
BMC Microbiology, 2011 Background Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual ...
Gram Lone +3 more
doaj +1 more source