Results 61 to 70 of about 5,562 (217)
Dinuclear Lanthanide (III) coordination polymers in a domino reaction [PDF]
, 2015 A systematic study was performed to further optimise the catalytic room-temperature synthesis of trans-4,5- diaminocyclopent-2-enones from 2-furaldehyde and primary or secondary amines under a non-inert atmosphere. For this purpose, a series of dinuclear
Abdul-Sada, Alaa +5 more
core +2 more sources
2D Assemblies Based on a Tetraphenylethylene D,L‐Cyclic Peptide Scaffold
Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.A new scaffold based on four nanotube‐forming cyclic peptide units attached to a tetraphenylethene (TPE) core with pH‐dependent self‐assembly that provides light‐emitting 2D nanosheets with controlled thickness is described. Abstract Two dimensional (2D) materials and aggregation‐induced emission (AIE) fluorophores have recently gained attention due to
Alfonso Bayón‐Fernández +7 more
wiley +2 more sources
Peptoid special delivery [PDF]
Science-Business eXchange, 2008 Scientists at the University of Karlsruhe have designed peptoids that deliver therapeutics to intracellular targets without any toxic effects in vitro. The technique could produce carriers that deliver drugs exclusively to specific intracellular locations—if peptoids show as much promise in vivo.
openaire +1 more source
Exploiting protected maleimides to modify oligonucleotides, peptides and peptide nucleic acids [PDF]
, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Brun Cubero, Omar +3 more
core +2 more sources
In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents. [PDF]
PLoS ONE, 2016 Bacterial resistance to conventional antibiotics is a global threat that has spurred the development of antimicrobial peptides (AMPs) and their mimetics as novel anti-infective agents.
Ann M Czyzewski +7 more
doaj +1 more source
β-Peptoid Foldamers at Last [PDF]
Accounts of Chemical Research, 2015 For a long time, peptides were considered unsuitable for drug development due to their inherently poor pharmacokinetic properties and proteolytic susceptibility. However, this paradigm has changed significantly in the past decade with the approval of numerous antibodies and proteins as drugs.
Laursen, Jonas S +2 more
openaire +3 more sources
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
Cross Metathesis Assisted Solid-Phase Synthesis of Glycopeptoids [PDF]
, 2012 A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good ...
Grubbs, Robert H. +3 more
core +1 more source
Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids
Molecules, 2021 Outstanding affinity and specificity are the main characteristics of peptides, rendering them interesting compounds for basic and medicinal research. However, their biological applicability is limited due to fast proteolytic degradation.
Claudine Nicole Herlan +7 more
doaj +1 more source
Targeted Drug Delivery using Peptoid Based Nanospheres [PDF]
, 2016 While medicine has improved greatly in the last couple of decades, there are negative side effects that accompany many drugs. Undesirable side effects could be greatly reduced if non-systemic drug delivery systems were used because the medicine would ...
Smith, Kaylee J
core +2 more sources