Results 61 to 70 of about 3,952 (212)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Peptoid helicity modulation: precise control of peptoid secondary structures via position-specific placement of chiral monomers

, 2014
The degree of peptoid helicity can be effectively modulated by position-specific incorporation of alpha-chiral aromatic monomers. In this study, we report the structural role of each monomer position collected from 30 comprehensive model peptoid ...
Shin, Hye-Min, Kang, Chang-Muk, Seo, Ji Won, Yoon, Myung-Han   +3 more
core   +1 more source

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents. [PDF]

PLoS ONE, 2016
Bacterial resistance to conventional antibiotics is a global threat that has spurred the development of antimicrobial peptides (AMPs) and their mimetics as novel anti-infective agents.
Ann M Czyzewski, Håvard Jenssen, Christopher D Fjell, Matt Waldbrook, Nathaniel P Chongsiriwatana, Eddie Yuen, Robert E W Hancock, Annelise E Barron   +7 more
doaj   +1 more source

Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids

Molecules, 2021
Outstanding affinity and specificity are the main characteristics of peptides, rendering them interesting compounds for basic and medicinal research. However, their biological applicability is limited due to fast proteolytic degradation.
Claudine Nicole Herlan, Anna Sonnefeld, Thomas Gloge, Julian Brückel, Luisa Chiara Schlee, Claudia Muhle-Goll, Martin Nieger, Stefan Bräse   +7 more
doaj   +1 more source

A readily applicable strategy to convert peptides to peptoid-based therapeutics. [PDF]

PLoS ONE, 2013
Incorporation of unnatural amino acids and peptidomimetic residues into therapeutic peptides is highly efficacious and commonly employed, but generally requires laborious trial-and-error approaches.
Minyoung Park, Modi Wetzler, Theodore S Jardetzky, Annelise E Barron   +3 more
doaj   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

Scientific Reports, 2017
Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of ...
Shan Liu, Shinae Park, Grant Allington, Frances Prelli, Yanjie Sun, Mitchell Martá-Ariza, Henrieta Scholtzova, Goutam Biswas, Bernard Brown, Philip B. Verghese, Pankaj D. Mehta, Yong-Uk Kwon, Thomas Wisniewski   +12 more
doaj   +1 more source

Chemoselective Aldehyde and Imine Reduction by a Macrocyclic Triazole–Borane Complex Triggered by a Non‐innocent Proton–Hydride Interaction

European Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.
This work describes the study on a new recyclable reagent, based on a macrocyclic triazole–borane complex. It showed high chemoselectivity for aldehyde reduction and reductive amination over ketones. This selectivity is driven by a noncovalent hydride–proton interaction that stabilizes the transition state for aldehydes but is sterically inhibited in ...
Luca Di Marino, Artur Brotons Rufes, Rosaria Schettini, Giorgio Della Sala, Francesco De Riccardis, Chiara Costabile, Irene Izzo   +6 more
wiley   +1 more source

Peptoid-peptide hybrids that bind syk SH2 domains involved in signal transduction

, 2001
Peptoid-peptide hybrids are oligomeric peptidomimetics that contain one or more N-substituted glycine residues. In these hybrids, the side chains of one or several amino acids are shifted from the -carbon atom to the amide nitrogen atom.
Marcel J. E. Fischer (23981397), Wendy van De Wiel (23981394), Rob M. J. Liskamp (7270820), Martin Flüeck (23979267), John A. W. Kruijtzer (23981391), Rob Ruijtenbeek (59404), Frank A. M. Redegeld (23981400), Frans P. Nijkamp (23981403)   +7 more
core  

Helical Folding of Abiotic Chiral Poly(phosphodiester)s

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Design and structural analysis of a new class of phosphodiester foldamers are presented. These oligomers that fold into single helical architecture showed length and temperature stability dependence comparable to DNA duplexes. ABSTRACT Functions of biomolecules are intimately linked to their structures which result from the folding of a linear sequence
Ranajit Barman, Brice Kauffmann, Jean‐François Lutz, Victor Maurizot   +3 more
wiley   +1 more source