Results 51 to 60 of about 1,730 (178)
In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents. [PDF]
PLoS ONE, 2016 Bacterial resistance to conventional antibiotics is a global threat that has spurred the development of antimicrobial peptides (AMPs) and their mimetics as novel anti-infective agents.
Ann M Czyzewski +7 more
doaj +1 more source
A Convenient Strategy to Access Diverse Libraries of Amphiphilic Compounds Based on Glycopeptoids
Chirality, Volume 38, Issue 7, July 2026.A synthetic platform based on a convergent synthetic strategy enables rapid access to a diverse amphiphilic glycopeptoids library. These modular systems exhibit self‐assembly into nanoscale aggregates, highlighting their potential as customizable platforms for drug delivery, biomimetic materials, and membrane protein stabilization.
Ludovica Dei +9 more
wiley +1 more source
Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids
Molecules, 2021 Outstanding affinity and specificity are the main characteristics of peptides, rendering them interesting compounds for basic and medicinal research. However, their biological applicability is limited due to fast proteolytic degradation.
Claudine Nicole Herlan +7 more
doaj +1 more source
Characterization of Novel Antimicrobial Peptoids [PDF]
Antimicrobial Agents and Chemotherapy, 1999 ABSTRACT Peptoids differ from peptides in that peptoids are composed of N-substituted rather than alpha-carbon-substituted glycine units. In this paper we report the in vitro and in vivo antibacterial activities of several antibacterial peptoids discovered by screening combinatorial chemistry libraries for bacterial growth ...
B, Goodson +12 more
openaire +2 more sources
Journal of Biomedical Materials Research Part A, Volume 114, Issue 6, June 2026.ABSTRACT Burn wounds present significant clinical challenges due to high infection risk, delayed healing, and extensive tissue damage. The development of biomimetic skin substitutes capable of simultaneously supporting tissue regeneration and preventing infection remains a critical need in burn wound management. In this study, a novel ceragenin (CSA‐44)
Nawal Aljayyousi +9 more
wiley +1 more source
A readily applicable strategy to convert peptides to peptoid-based therapeutics. [PDF]
PLoS ONE, 2013 Incorporation of unnatural amino acids and peptidomimetic residues into therapeutic peptides is highly efficacious and commonly employed, but generally requires laborious trial-and-error approaches.
Minyoung Park +3 more
doaj +1 more source
β-Peptoid Foldamers at Last [PDF]
Accounts of Chemical Research, 2015 For a long time, peptides were considered unsuitable for drug development due to their inherently poor pharmacokinetic properties and proteolytic susceptibility. However, this paradigm has changed significantly in the past decade with the approval of numerous antibodies and proteins as drugs.
Laursen, Jonas S +2 more
openaire +3 more sources
Role of Histidine‐Containing Peptoids in Accelerating the Kinetics of Calcite Growth
Advanced Functional Materials, Volume 36, Issue 34, 27 April 2026.Amphiphilic histidine‐containing peptoids mimic carbonic anhydrase (CA) to accelerate calcite step growth. In the presence of Zn2+, they promote the deprotonation of HCO3−, the desolvation of Ca2+, and the reorganization of interfacial hydration layers, thereby reducing the activation barrier for calcite growth.
Mingyi Zhang +5 more
wiley +1 more source
Scientific Reports, 2017 Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of ...
Shan Liu +12 more
doaj +1 more source
Cancer Nexus, Volume 2, Issue 2, April 2026.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source