Results 11 to 20 of about 17,763 (235)

Peptidomimetics [PDF]

Accounts of Chemical Research, 2008
Topic: Synthetic Molecules as Tools for Chemical Biology, Synthetic Proteins to Explore Biology.
Wu, Yun-Dong, Gellman, Sam
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The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid

Pharmaceuticals, 2023
Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens,
Valeria Cafaro, Andrea Bosso, Ilaria Di Nardo, Assunta D’Amato, Irene Izzo, Francesco De Riccardis, Marialuisa Siepi, Rosanna Culurciello, Nunzia D’Urzo, Emiliano Chiarot, Antonina Torre, Elio Pizzo, Marcello Merola, Eugenio Notomista   +13 more
doaj   +1 more source

Identification and Application of Two Promising Peptide Ligands for the Immunodetection of Imidacloprid Residue

Foods, 2022
As the most widely used neonicotinoid insecticide, it is of great significance to explore the immunoreagents and immunoassays for imidacloprid (IMI) residue.
Tianyang You, Yuan Ding, Yue Huang, Yang Lu, Minghua Wang, Xiude Hua   +5 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Journal of Medicinal Chemistry, 2021
A novel series of peptidomimetic aldehydes was designed and synthesized to target 3C protease (3Cpro) of enterovirus 71 (EV71). Most of the compounds exhibited high antiviral activity, and among them, compound 18p demonstrated potent enzyme inhibitory ...
Wenhao Dai, D. Jochmans, Hang Xie, Hang Yang, Jian Li, H. Su, Di Chang, Jiang Wang, Jingjing Peng, Lili Zhu, Yong Nian, R. Hilgenfeld, Hualiang Jiang, Kaixian Chen, Lei-ke Zhang, Yechun Xu, J. Neyts, Hong Liu   +17 more
semanticscholar   +1 more source

Peptide–Protein Interactions: From Drug Design to Supramolecular Biomaterials

Molecules, 2021
The self-recognition and self-assembly of biomolecules are spontaneous processes that occur in Nature and allow the formation of ordered structures, at the nanoscale or even at the macroscale, under thermodynamic and kinetic equilibrium as a consequence ...
Andrea Caporale, Simone Adorinni, Doriano Lamba, Michele Saviano   +3 more
doaj   +1 more source

Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery

Biomolecules, 2022
Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj   +1 more source

Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

Frontiers in Chemistry, 2021
Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug targets because they can produce fewer on-target side effects, improved selectivity, and better biological specificity (e.g., biased signaling or probe dependence) than
Keith M. Olson, John R. Traynor, John R. Traynor, Andrew Alt, Andrew Alt   +4 more
doaj   +1 more source

Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

Communications Biology, 2022
The transmembrane serine protease 2 (TMPRSS2) primes the SARS-CoV-2 Spike (S) protein for host cell entry and represents a promising target for COVID-19 therapy.
Lukas Wettstein, P. Knaff, C. Kersten, P. Müller, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Maximilian Brückner, M. Hoffmann, S. Pöhlmann, T. Schirmeister, K. Landfester, J. Münch, V. Mailänder   +13 more
semanticscholar   +1 more source

Universal Peptidomimetics [PDF]

Journal of the American Chemical Society, 2010
This paper concerns peptidomimetic scaffolds that can present side chains in conformations resembling those of amino acids in secondary structures without incurring excessive entropic or enthalpic penalties. Compounds of this type are referred to here as minimalist mimics.
Eunhwa, Ko, Jing, Liu, Lisa M, Perez, Genliang, Lu, Amber, Schaefer, Kevin, Burgess   +5 more
openaire   +2 more sources

Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus

Comput. Biol. Medicine, 2020
This paper concerns study of the genome of the Wuhan Seafood Market isolate believed to represent the causative agent of the disease COVID-19. This is to find a short section or sections of viral protein sequence suitable for preliminary design proposal ...
B. Robson
semanticscholar   +1 more source