Results 11 to 20 of about 14,095 (224)

Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design. [PDF]

PLoS ONE, 2013
Peptidomimetics are classes of molecules that mimic structural and functional attributes of polypeptides. Peptidomimetic oligomers can frequently be synthesized using efficient solid phase synthesis procedures similar to peptide synthesis ...
Kevin Drew, P Douglas Renfrew, Timothy W Craven, Glenn L Butterfoss, Fang-Chieh Chou, Sergey Lyskov, Brooke N Bullock, Andrew Watkins, Jason W Labonte, Michael Pacella, Krishna Praneeth Kilambi, Andrew Leaver-Fay, Brian Kuhlman, Jeffrey J Gray, Philip Bradley, Kent Kirshenbaum, Paramjit S Arora, Rhiju Das, Richard Bonneau   +18 more
doaj   +3 more sources

Peptidomimetics [PDF]

Accounts of Chemical Research, 2008
Topic: Synthetic Molecules as Tools for Chemical Biology, Synthetic Proteins to Explore Biology.
Wu, Yun-Dong, Gellman, Sam
  +6 more sources

Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity

Drug Design, Development and Therapy, 2015
Tatjana Momic,1 Jehoshua Katzhendler,1 Ela Shai,2 Efrat Noy,3 Hanoch Senderowitz,3 Johannes A Eble,4 Cezary Marcinkiewicz,5 David Varon,2 Philip Lazarovici11School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of ...
Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P   +8 more
doaj   +1 more source

Universal Peptidomimetics [PDF]

Journal of the American Chemical Society, 2010
This paper concerns peptidomimetic scaffolds that can present side chains in conformations resembling those of amino acids in secondary structures without incurring excessive entropic or enthalpic penalties. Compounds of this type are referred to here as minimalist mimics.
Eunhwa, Ko, Jing, Liu, Lisa M, Perez, Genliang, Lu, Amber, Schaefer, Kevin, Burgess   +5 more
openaire   +2 more sources

Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture

Viruses, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more than two million deaths worldwide since it was first detected in 2019.
Allison Bakovic, Kenneth Risner, Nishank Bhalla, Farhang Alem, Theresa L. Chang, Warren K. Weston, Jane A. Harness, Aarthi Narayanan   +7 more
doaj   +1 more source

Peptidomimetic-Based Asymmetric Catalysts

, 2023
Despite the great advantages of peptidomimetic scaffolds, there are only a few examples of their application in the field of asymmetric catalysis. Peptidomimetic scaffolds offer numerous advantages related to their easy preparation, modular and tunable ...
Alicja Malgorzata Araszczuk, Rosaria Schettini, Ibrahim Khettar   +2 more
core   +1 more source

Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions

Beilstein Journal of Organic Chemistry, 2023
Peptidomimetics with a substituted imidazo[1,2-a]pyridine fragment were synthesized by a tandem of Groebke–Blackburn–Bienaymé and Ugi reactions. The target products contain substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores ...
Oleksandr V. Kolomiiets, Alexander V. Tsygankov, Maryna N. Kornet, Aleksander A. Brazhko, Vladimir I. Musatov, Valentyn A. Chebanov   +5 more
doaj   +1 more source

QSAR Modelling of Peptidomimetic Derivatives towards HKU4-CoV 3CL^pro Inhibitors against MERS-CoV

Chemistry, 2021
In this paper, we report the relationship between the anti-MERS-CoV activities of the HKU4 derived peptides for some peptidomimetic compounds and various descriptors using the quantitative structure activity relationships (QSAR) methods.
Imad Hammoudan, Soumaya Matchi, Mohamed Bakhouch, Salah Belaidi, Samir Chtita   +4 more
doaj   +1 more source

1,2,3-Triazoles as Biomimetics in Peptide Science

Molecules, 2021
Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo.
Naima Agouram, El Mestafa El Hadrami, Abdeslem Bentama   +2 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets-Then, Now, and the Future. [PDF]

Med Res Rev
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Sleebs BE.
europepmc   +2 more sources