Results 41 to 50 of about 12,487 (241)

Peptidomimetic Wet-Adhesive PEGtides with Synergistic and Multimodal Hydrogen Bonding

, 2022
The remarkable underwater adhesion of mussel foot proteins has long been an inspiration in the design of peptidomimetic materials. Although the synergistic wet adhesion of catechol and lysine has been recently highlighted, the critical role of the ...
Lim, Chanoong, Park, Jinwoo, Shin, Eeseul, Lee, Kyung Min, Lee, Joonhee, Park, Suebin, Lee, Dong Woog, Kim, Byeong-Su, Kim, Minseong, Kwak, Sang Kyu   +9 more
core   +2 more sources

A cyclic carbo-isosteric penta-depsipeptide: cyclo(Phe1–d-Ala2–Gly3–Phe4–APO5)

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, cyclo(Phe1–d-Ala2–Gly3–Phe4–APO5), C26H32N4O5, is the minor diastereoisomer of a cyclic penta-peptidomimetic analogue containing a novel 2-aminopropyl lactone (APO) motif, which displays the same number of atoms as the native amino ...
Stéphanie M. Guéret, Trixie Wagner
doaj   +1 more source

Peptidomimetic Catalysts as Chemical Probes of Weak Intermolecular Forces: An Insight into The N-H…Cl-C H-Bonding Interaction

, 2023
Despite the widespread use of amide bond isosteres, there is only a limited understanding of their H-bonding mimicry of amides. With experimental and computational approaches, we have explored the hydrogen bonding acceptor potential of the chlorine ...
Chihiro, Iio, Junko, Fujimoto, Nobuyuki, Mase, Kohei, Sato, Takuya, Chiba, Takuma, Nishizawa, Yuki, Kodama, Tetsuo, NARUMI   +7 more
core   +1 more source

Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors—A Comprehensive Reactivity and Selectivity Study [PDF]

, 2023
Covalent peptidomimetic protease inhibitors have gained a lot of attention in drug development in recent years. They are designed to covalently bind the catalytically active amino acids through electrophilic groups called warheads.
Müller, Patrick, Stefan Josef Hammerschmidt, Tanja Schirmeister, Rodríguez, Santiago, Patrick Müller, Kersten, Christian, Laura Agost-Beltrán, Zimmer, Collin, de la Hoz-Rodríguez, Sergio, Christian Kersten, De la Hoz Rodríguez, Sergio, Schirmeister, Tanja, Bernd Engels, Marvin Schwickert, Florenci V. Gonzàlez, Gonzàlez, Florenci V., Jan Laurenz Meidner, Collin Zimmer, Hammerschmidt, Stefan Josef, Kevin Schwickert, Schwickert, Kevin, Meyr, Jessica, González, Florenci, Jessica Meyr, Albin Lahu, Lahu, Albin, Diemer, Kira, Meta, Mergim, Santiago Rodríguez, Schwickert, Dr. Kevin, Engels, Bernd, Agost Beltrán, Laura, Meidner, Jan Laurenz, Frey, Ariane, Neumann, Wilhelm, Ariane Frey, Sergio de la Hoz-Rodríguez, Wilhelm Neumann, Schwickert, Marvin, Agost-Beltrán, Laura, Kira Diemer, Mergim Meta   +41 more
core   +1 more source

Targeting protein–protein interaction for immunomodulation: A sunflower trypsin inhibitor analog peptidomimetic suppresses RA progression in CIA model

Journal of Pharmacological Sciences, 2022
Protein–protein interactions (PPI) of co-stimulatory molecules CD2-CD58 are important in the early stage of an immune response, and increased expression of these co-stimulatory molecules is observed in the synovial region of joints in rheumatoid ...
Achyut Dahal, Pravin Parajuli, Sitanshu S. Singh, Leeza Shrestha, Jafrin Jobayer Sonju, Prajesh Shrestha, Ioulia Chatzistamou, Seetharama Jois   +7 more
doaj   +1 more source

Cross-resistance between peptidomimetic 1 and 2.

, 2013
Association between Minimum Inhibitory Concentration (MIC) for peptidomimetic 1 and peptidomimetic 2 against lineage no. 2 (black circles) and lineage no. 5 (white circles). E. coli ATCC 25922 MIC is highlighted with an asterisk (i.e.
Line Hein-Kristensen (454385), Lone Gram (142505), Henrik Franzyk (454386), Anne Holch (454387)   +3 more
core   +1 more source

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Frontiers in Pharmacology, 2020
The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders.
Nicholas Barlow, Philip E. Thompson
doaj   +1 more source

Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1

Molecules, 2022
Protein N-terminal methyltransferase 1 (NTMT1) recognizes a unique N-terminal X-P-K/R motif (X represents any amino acid other than D/E) and transfers 1–3 methyl groups to the N-terminal region of its substrates.
Guangping Dong, Iredia D. Iyamu, Jonah Z. Vilseck, Dongxing Chen, Rong Huang   +4 more
doaj   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Therapeutic peptides and peptidomimetics

Current Opinion in Biotechnology, 1997
Peptidomimetics are one set of probes used in the transition pathway of small molecule drug design. Cyclization of the peptide backbone and its modification with aromatic residues constitutes an effective approach to mimetic drug design and circumvents obstacles associated with delivery and formulation of peptides and peptidomimetics. In the past year,
T, Kieber-Emmons, R, Murali, M I, Greene
openaire   +2 more sources