Results 61 to 70 of about 14,095 (224)

Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Identification of highly selective type II kinase inhibitors is described. Two different chiral peptidomimetic scaffolds were introduced on the tail region of non-selective type II kinase inhibitor GNF-7 to enhance the selectivity.
Seo-Jung Han, Jae Eun Jung, Do Hee Oh, Minsup Kim, Jae-Min Kim, Kyung-Sook Chung, Hee-Soo Han, Jeong-Hun Lee, Kyung-Tae Lee, Hee Jin Jeong, In Ho Park, Eunkyeong Jeon, Jeon-Soo Shin, Dongkeun Hwang, Art E. Cho, Duck-Hyung Lee, Taebo Sim   +16 more
doaj   +1 more source

Peptides and Peptidomimetics as Immunomodulators [PDF]

Immunotherapy, 2014
Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the conformational aspects of peptides,
Ameya S, Gokhale, Seetharama, Satyanarayanajois   +1 more
openaire   +2 more sources

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

MIC (µg/mL) for wild-type E. coli and four peptidomimetic-adapted isolates against peptidomimetic 1 in standard MHB media and in MHB media supplemented with 25% human blood plasma.

, 2013
aAbility of plasma to interact synergistically with peptidomimetic 1.
Line Hein-Kristensen (454385), Lone Gram (142505), Henrik Franzyk (454386), Anne Holch (454387)   +3 more
core   +1 more source

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Chemical Synthesis and Functional Screening of an 800 000‐Member Library Using a Peptide‐Pairing Strategy

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Chemical peptide synthesis allows the generation of structurally highly diverse compounds suited for ligand development, but current methods in parallel peptide synthesis limit the achievable library size to a few thousand. A strategy is presented based on combinatorial pairing of short peptides via disulfide linkage that enables the generation and ...
Anne Zarda, Xingwang Deng, Edward Will, Thomas Emel, Maylin Romero, Christian Heinis   +5 more
wiley   +2 more sources

Synthesis of a Peptidomimetic Tricyclic Tetrahydrobenzo[ij]quinoline as a VLA-4 Antagonist

, 2016
Synthesis of a Peptidomimetic Tricyclic Tetrahydrobenzo[ij]quinoline as a VLA-4 ...
Wen-Bin Ho (3048585), Chris Broka (3048588)   +1 more
core   +1 more source

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions [PDF]

, 2015
We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin.
Arosio, Daniela, Parisini, Emilio, M. Figini, D. Arosio, M. Civera, Civera, Monica, A. Tomassetti, C. Colombo, Tomassetti, Antonella, Fanelli, Roberto, C. Casagrande, E. Parisini, Manzoni, Leonardo, Doro, Fabio, U. Piarulli, L. Manzoni, PIARULLI, UMBERTO, E. Luison, Alberti, Chiara, L. Belvisi, Colombo, Cinzia, Luison, Elena, F. Doro, Belvisi, Laura, Figini, Mariangela, C. Alberti, R. Fanelli, Casagrande, Cesare, R Fanelli, M Civera, U Piarulli, L Belvisi, D Arosio, C Colombo, F Doro, L Manzoni, M Figini, C Alberti, E Luison, A Tomassetti, E Parisini, C Casagrande   +41 more
core   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source