Results 81 to 90 of about 14,095 (224)
Molecules, 2020 We present the synthesis and structural study of a new peptidomimetic of morphiceptin, which can formally be considered as the result of the replacement of the central proline residue of this natural analgesic drug with a subunit of (1S,2R,3S,4S,5R)-2 ...
Raquel Soengas +5 more
doaj +1 more source
Peptidomimetic building blocks for the synthesis of sulfonamide peptoids
, 2000 There is a constant demand for novel building blocks for combinatorial chemistry applications. A one-pot synthesis of a novel class of peptidomimetic building blocks to be used for the preparation of sulfonamide peptoids, is presented here.
van Ameijde, J. +3 more
core +1 more source
Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li +15 more
wiley +2 more sources
Strategies for the Development of Conotoxins as New Therapeutic Leads
Marine Drugs, 2013 Peptide toxins typically bind to their target ion channels or receptors with high potency and selectivity, making them attractive leads for therapeutic development. In some cases the native peptide as it is found in the venom from which it originates can
Jonathan B. Baell +2 more
doaj +1 more source
, 2013 Grouping of genome-sequenced peptidomimetic-adapted isolates based on comparison to wild type (wt) MIC value (8 µg/mL).
Line Hein-Kristensen (454385) +3 more
core +1 more source
Protein Science, Volume 35, Issue 11, November 2026.Abstract Electrostatic interactions play a crucial role in protein structure, stability, and function. We present Bluues2, a significantly enhanced web server for calculating electrostatic properties of proteins using the Generalized Born model. The new version features improved accuracy through refined GB radius calculations using NanoShaper for ...
Damiano Piovesan +6 more
wiley +1 more source
Solid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease
, 2016 The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 protease are known to act as weak inhibitors of the enzyme and have been used
Nathalie Goudreau (1957837) +7 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2013 A variety of stable, small-molecule peptidomimetic ligands have been developed to elucidate the mechanism by which the neuropeptide Pro-Leu-Gly-NH2 (PLG) modulates dopaminergic neurotransmission.
Swapna Bhagwanth +2 more
doaj +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, Volume 183, Issue 22, Page 6607-6626, November 2026.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Synthesis of a novel tricyclic peptidomimetic Scaffold
, 2008 An efficient method to synthesize a novel rigid tricyclic peptidomimetic scaffold through ring-closure of amino-functionalized bicyclic 2-pyridones has been discovered.
Sellstedt, Magnus,, Almqvist, Fredrik,
core +2 more sources