Results 81 to 90 of about 17,763 (235)

Strategies for the Development of Conotoxins as New Therapeutic Leads

Marine Drugs, 2013
Peptide toxins typically bind to their target ion channels or receptors with high potency and selectivity, making them attractive leads for therapeutic development. In some cases the native peptide as it is found in the venom from which it originates can
Jonathan B. Baell, Ryan M. Brady, Raymond S. Norton   +2 more
doaj   +1 more source

Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper

Journal of the American Chemical Society, 2018
Hydrogen-bonding-driven three-dimensional (3D) assembly of a peptidomimetic zipper has been established for the first time by using an α/AApeptide zipper that assembles into a de novo lattice arrangement through two layers of hydrogen-bonded linker ...
P. Teng, Zheng Niu, Fengyu She, Mi Zhou, Peng Sang, Geoffrey M. Gray, G. Verma, L. Wojtas, A. van der Vaart, Shengqian Ma, Jianfeng Cai   +10 more
semanticscholar   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Molecular Cancer Therapeutics, 2018
Because of their roles in the evasion of apoptosis, inhibitor of apoptosis proteins (IAP) are considered attractive targets for anticancer therapy. Antagonists of these proteins have the potential to switch prosurvival signaling pathways in cancer cells ...
G. Ward, E. J. Lewis, J. Ahn, Christopher N. Johnson, J. Lyons, V. Martins, J. Munck, S. Rich, T. Smyth, N. Thompson, Pamela A. Williams, N. Wilsher, N. Wallis, G. Chessari   +13 more
semanticscholar   +1 more source

Therapeutic peptides and peptidomimetics

Current Opinion in Biotechnology, 1997
Peptidomimetics are one set of probes used in the transition pathway of small molecule drug design. Cyclization of the peptide backbone and its modification with aromatic residues constitutes an effective approach to mimetic drug design and circumvents obstacles associated with delivery and formulation of peptides and peptidomimetics. In the past year,
T, Kieber-Emmons, R, Murali, M I, Greene
openaire   +2 more sources

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

The Chemical Record, EarlyView.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros, Livia C. L. Valente, Thiago Barcellos, Daniela Hartwig, Laura Abenante, Eder J. Lenardão   +5 more
wiley   +1 more source

Development of peptidomimetic ligands of Pro-Leu-Gly-NH2 as allosteric modulators of the dopamine D2 receptor

Beilstein Journal of Organic Chemistry, 2013
A variety of stable, small-molecule peptidomimetic ligands have been developed to elucidate the mechanism by which the neuropeptide Pro-Leu-Gly-NH2 (PLG) modulates dopaminergic neurotransmission.
Swapna Bhagwanth, Ram K. Mishra, Rodney L. Johnson   +2 more
doaj   +1 more source

De novo Left-Handed Synthetic Peptidomimetic Foldamers

Angewandte Chemie, 2018
Development of peptidomimetic helical foldamers with a wide repertoire of functions is of significant interest. Herein, for the first time, we report the X-ray crystal structures of a series of homogeneous L-sulfono-γ-AA foldamers, and elucidate their ...
Fengyu She, P. Teng, Alfredo Peguero-Tejada, Minghui Wang, Ning Ma, Timothy Odom, Mi Zhou, Erald Gjonaj, L. Wojtas, A. van der Vaart, Jianfeng Cai   +10 more
semanticscholar   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic

ACS Chemical Neuroscience, 2018
Protein–protein interactions (PPI) offer unexploited opportunities for CNS drug discovery and neurochemical probe development. Here, we present ZL181, a novel peptidomimetic targeting the PPI interface of the voltage-gated Na+ channel Nav1.6 and its ...
Syed R Ali, Zhiqing Liu, M. Nenov, O. Folorunso, A. Singh, F. Scala, Haiying Chen, T. F. James, Musaad A. Alshammari, Neli I Panova-Elektronova, M. A. White, Jia Zhou, F. Laezza   +12 more
semanticscholar   +1 more source