Results 71 to 80 of about 14,095 (224)

Synthesis of a peptidomimetic analog of the binding domain of rapamycin

, 1997
Stereoselective synthesis of a peptidomimetic analog of the binding domain of rapamycin starting from N,N-dibenzyl-R-alaninal is ...
Azhar Hussain, Khaja, Chakraborty, Tushar K.   +1 more
core   +1 more source

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

A non-hydrolysable peptidomimetic for mitochondrial targeting

Peptidomimetics, molecules that mimic the activity of natural peptides with improved stability or bioavailability, have emerged as interesting materials with applications in biomedicine.
Torralba-Maldonado, Daniel, Pazo, Marta, Montenegro, Javier, Illa, Ona, Folgar-Cameán, Yeray, Royo, Miriam, Fulias-Guzmán, Patricia, Máximo-Moreno, Irene   +7 more
core   +1 more source

Design of Peptidomimetic Functionalized Cholesterol Based Lipid Nanoparticles for Efficient Delivery of Therapeutic Nucleic Acids

Molecules, 2019
Lipid nanoparticles (LNP) are the most potent carriers for the delivery of nucleic acid-based therapeutics. The first FDA approved a short interfering RNA (siRNA) drug that uses a cationic LNP system for the delivery of siRNA against human transthyretin (
Ehexige Ehexige, Tsogzolmaa Ganbold, Xiang Yu, Shuqin Han, Huricha Baigude   +4 more
doaj   +1 more source

Inhibitory Activity of Red Panda Islet Amyloid Polypeptide on Human IAPP Aggregation

Journal of Peptide Science, Volume 32, Issue 12, December 2026.
The figure shows the comparison of (a) human islet amyloid polypeptide (hIAPP) self‐assembling into a fibril structure and (b) a model of hIAPP self‐assembling in the presence of red panda islet amyloid polypeptide (IAPP). The figure was produced from PDB file 6Y1A using Swiss PDB viewer software.
Lauren Phillips, Elizabeth L. Moffet, Judah Mayfield, Eden L. Jonick, Luiza A. Nogaj, David A. Moffet   +5 more
wiley   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, Volume 179, Issue 4, Page 537-553, December 2026.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

List of best peptidomimetic inhibitors of IDE designed from LT10 peptide, along with their docking and interaction details.

, 2015
List of best peptidomimetic inhibitors of IDE designed from LT10 peptide, along with their docking and interaction details.
Sonali Gopichand Chavan (713710), Deepti Dileep Deobagkar (713711)   +1 more
core   +1 more source

Novel Furanoid α-Substitued α-Amino Acid as a Potent Turn Mimic in Peptide Synthesis

Molecules, 2006
A stereoselective approach has been developed to the new sugar amino acid and potential potent turn mimic 5-O-(tert-butyldimethylsilyl)-3-deoxy-1,2-O- isopropylidene-3-methoxycarbonylamino-α-D-xylofuranose 3-C-carboxylic acid (12), via the [3,3 ...
Jana Raschmanová, Jozef Gonda, Miroslava Martinková   +2 more
doaj   +1 more source

Halogenated Tryptophans Improve Integrin αVβ6 Affinity of Cyclic RGD Peptides and Provide Handles for Late‐Stage Derivatization

Chemistry – A European Journal, Volume 32, Issue 41, 3 November 2026.
Lighting up αVβ6: Halotryptophan engineering converts an RGD scaffold into a modular αVβ6 ligand platform, enabling picomolar affinity and late‐stage functionalization. The resulting probes combine high selectivity with fluorescence for FACS and tumor imaging.
Beate Nachtigall, Caroline Brinkmann, Jana Langosch, Anke Nieß, Norbert Sewald   +4 more
wiley   +1 more source

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi, Mariko Akiba, Marin Yokomine, Masatake Sugita, Koji Umezawa, Yuto Hirota, Yutaka Akiyama, Jumpei Morimoto, Shinsuke Sando   +8 more
wiley   +2 more sources