Results 71 to 80 of about 12,487 (241)
Self-Assembling Peptidomimetic Monolayer Nucleates Oriented CdS Nanocrystals
, 2016 Self-Assembling Peptidomimetic Monolayer Nucleates Oriented CdS ...
Haimanot Bekele (3007545) +2 more
core +1 more source
Chemistry – A European Journal, EarlyView.A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián +4 more
wiley +1 more source
An Artificial Antiparallel β-Sheet Containing a New Peptidomimetic Template
, 2016 An Artificial Antiparallel β-Sheet Containing a New Peptidomimetic ...
James S. Nowick (1272555) +3 more
core +1 more source
Chemistry – A European Journal, EarlyView.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
A non-hydrolysable peptidomimetic for mitochondrial targeting
Peptidomimetics, molecules that mimic the activity of natural peptides with improved stability or bioavailability, have emerged as interesting materials with applications in biomedicine.
Torralba-Maldonado, Daniel +7 more
core +1 more source
Molecules, 2019 Lipid nanoparticles (LNP) are the most potent carriers for the delivery of nucleic acid-based therapeutics. The first FDA approved a short interfering RNA (siRNA) drug that uses a cationic LNP system for the delivery of siRNA against human transthyretin (
Ehexige Ehexige +4 more
doaj +1 more source
Synthesis of an IGD peptidomimetic with motogenic activity
, 2005 Rational design and synthesis of an IGD peptidomimetic substrate with significant motogenic ...
Ellis, Ian R.; id_orcid +7 more
core +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Promising Antibiofilm Activity of Peptidomimetics [PDF]
Frontiers in Microbiology, 2018 Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss. Scientific efforts have been made over the past few decades, but so far there is no effective treatment targeting the bacteria in biofilms. Antimicrobial peptidomimetics have been proposed
Rafael Gomes Von Borowski +4 more
openaire +3 more sources
Novel Furanoid α-Substitued α-Amino Acid as a Potent Turn Mimic in Peptide Synthesis
Molecules, 2006 A stereoselective approach has been developed to the new sugar amino acid and potential potent turn mimic 5-O-(tert-butyldimethylsilyl)-3-deoxy-1,2-O- isopropylidene-3-methoxycarbonylamino-α-D-xylofuranose 3-C-carboxylic acid (12), via the [3,3 ...
Jana Raschmanová +2 more
doaj +1 more source