Results 91 to 100 of about 14,095 (224)
Therapeutic peptides and peptidomimetics
Current Opinion in Biotechnology, 1997 Peptidomimetics are one set of probes used in the transition pathway of small molecule drug design. Cyclization of the peptide backbone and its modification with aromatic residues constitutes an effective approach to mimetic drug design and circumvents obstacles associated with delivery and formulation of peptides and peptidomimetics. In the past year,
T, Kieber-Emmons, R, Murali, M I, Greene
openaire +2 more sources
Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
DEVELOPMENT AND SYNTHESIS OF A NON-SPECIFIC IMMUNOMODULATING PEPTIDOMIMETIC
The use of peptides is associated with certain challenges. Due to proteolytic instability and a short plasma half life, peptides require the development and application of specialized delivery systems, which often limits their use to parenteral ...
M. S. Timofeeva +3 more
core +1 more source
, 2012 International audienceA concise synthetic route has been developed for the preparation of a constrained peptidomimetic pyrazinone building block. From hydroxy-L-lysine, the desired pyrazinone is obtained in 43% overall yield (6 steps) via an efficient ...
Janvier, Solenn +5 more
core +1 more source
, 2016 Conjugation of cytotoxic agents to targeting carriers (e.g. antibodies or small molecules) capable of selectively binding to tumor-specific antigens, is emerging as a successful strategy to overcome the drawbacks of traditional chemotherapy.[1] Being ...
D. Arosio +6 more
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Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau +3 more
wiley +1 more source
, 2008 Supplementary Methods from In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against α4β1 ...
Kit S. Lam (169301) +4 more
core +1 more source
Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4). [PDF]
, 2012 The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade.
Fujii, Nobutaka +3 more
core +1 more source
Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano +3 more
wiley +1 more source
Peptidomimetic–functionalized carbon nanotubes with antitrypsin activity
, 2010 Journal URL: www.elsevier.com/locate/carbonWater-soluble functionalized carbon nanotubes (CNTs) have been prepared and further conjugated through a stable covalent bond with two peptidomimetics.
Siskos, Argiris +8 more
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