Results 111 to 120 of about 14,095 (224)

Heterocycles in Peptidomimetics and Pseudopeptides: Design and Synthesis

Pharmaceuticals, 2012
This minireview provides a brief outline of the peculiar aspects of the preparation of peptidomimetic and pseudopeptidic structures containing heterocycles. In particular novel tricyclic structures are investigated as potential drugs.
Ambra Guarnaccio, Maria Funicello, Lucia Chiummiento, Iole Cerminara, Paolo Lupattelli   +4 more
doaj   +1 more source

Directed diversity-oriented synthesis. Ring-fused 5- to 10-membered rings from a common peptidomimetic 2-pyridone precursor

, 2012
A variety of ring-fused 2-pyridone-based central fragments were prepared using a strategy inspired by diversity-oriented synthesis.
Sellstedt, Magnus,, Prasad, G Krishna,, Almqvist, Fredrik,, Krishnan, K Syam,   +3 more
core   +1 more source

A simple peptidomimetic that self-associates on the solid state to form a nanoporous architecture containing chiral π-channels

, 2010
The crystal structure of a simple peptidomimetic compound, derived from phenylalanine, shows the formation of a nanoporous architecture containing monodimensional p-channels with the aromatic rings as the exclusive components of the chiral channel ...
Bolte, Michael, Luis, Santiago V., Escorihuela, Jorge, Galindo, Francisco, Becerril, Jorge, Burguete, M. Isabel   +5 more
core   +1 more source

Positional isomers of biphenyl antimicrobial peptidomimetic amphiphiles

, 2021
Small-molecule antimicrobial peptidomimetic amphiphiles represent a promising class of novel antimicrobials with the potential for widespread therapeutic application.
Andrew J Tague (20252577), Thomas V Riley (20215083), Paul A Keller (20253159), Papanin Putsathit (3213891), Stephen G Pyne (20250669)   +4 more
core   +1 more source

Transport of Peptidomimetic Drugs by the Intestinal Di/tri-peptide Transporter, PepT1

, 2002
The apical membrane of small intestinal enterocytes possess an uptake system for di- and tripeptides. The physiological function of the system is to transport small peptides resulting from digestion of dietary protein.
Birger Brodin, Nielsen, Carsten Uhd, Sven Frøkjaer, Frøkjaer, Sven, Brodin, Birger, Carsten Uhd Nielsen, Steffansen, Bente, Bente Steffansen   +7 more
core   +1 more source

Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates for tumor targeting

, 2016
Integrins are a large family of heterodimeric transmembrane glycoprotein receptors, composed by two non-covalently-associated subunits (α and β). Integrins αVβ3 and αVβ5 are overexpressed on blood vessels in human tumors but not on vessels in normal ...
D. Arosio, C. Albanese, L. Pignataro, M. Caruso, A. Marsiglio, L. Belvisi, B. Valsasina, D. Donati, F. Sola, F. Gasparri, C. Gennari, U. Piarulli, S. Troiani, A. Dal Corso   +13 more
core   +1 more source

Computer-aided design of amino acid-based therapeutics: a review

Drug Design, Development and Therapy, 2018
Tayebeh Farhadi,1 Seyed MohammadReza Hashemian1,2 1Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Clinical ...
Farhadi T, Hashemian SM
doaj  

β-turn peptidomimetic cyclic compounds

, 2001
Proteolytically stable small molecule -turn peptidomimetic compounds have been identified as agonists or antagonists of neurotrophin receptors, such as TrkA. A compound of particular interest binds the immunoglobulin-like C2 region of the extracellular
Saragovi, Horacio Uri, Burgess, Kevin
core  

Swimming into peptidomimetic chemical space using pepMMsMIMIC

, 2011
pepMMsMIMIC is a novel web-oriented peptidomimetic compound virtual screening tool based on a multi-conformers three-dimensional (3D)-similarity search strategy.
Joel Masciocchi, MORO, STEFANO, Matteo Floris, Stefano Moro, MASCIOCCHI JOEL, FANTON MARCO, J. Masciocchi, FLORIS MATTEO, M. Floris, Marco Fanton, M. Fanton, S. Moro, FLORIS, Matteo, Moro, S., Fanton, M, Masciocchi, J   +15 more
core   +1 more source

Expanding the scope and utility of the pyrrolinone peptidomimetic scaffold: Structural, biological and methodological advances

, 2005
The 3,5,5-pyrrolin-4-one peptidomimetic scaffold was designed and developed in the laboratories of Professor Amos B. Smith, III and Professor Ralph Hirschmann, as a novel nonpeptide peptidomimetic for the β-strand conformation of peptides and proteins ...
Charnley, Adam Kenneth
core