Results 111 to 120 of about 12,487 (241)
, 2021 To design novel inhibitors of the SARS-CoV-2 main protease (Mpro), we investigated the binding mode of the recently reported α-ketoamide inhibitors of this enzyme.
Al Awadh, Mohammed A +8 more
core
Protein and Peptide Inhibitors of Mineralization: A Systematic Review of In Vitro Studies
Journal of Peptide Science, Volume 32, Issue 7, July 2026.In vitro evidence from crystallization assays demonstrates that peptides inhibit mineral nucleation and crystal growth through sequence‐dependent interactions (acidic residues and phosphorylation) with mineral surfaces. In cell cultures, these molecules reduce calcium deposition and ALP activity and modulate the expression of biomineralization‐related ...
Alberto Mimila‐Cortes +7 more
wiley +1 more source
Peptidomimetic–functionalized carbon nanotubes with antitrypsin activity
, 2010 Journal URL: www.elsevier.com/locate/carbonWater-soluble functionalized carbon nanotubes (CNTs) have been prepared and further conjugated through a stable covalent bond with two peptidomimetics.
Siskos, Argiris +8 more
core
Heterocycles in Peptidomimetics and Pseudopeptides: Design and Synthesis
Pharmaceuticals, 2012 This minireview provides a brief outline of the peculiar aspects of the preparation of peptidomimetic and pseudopeptidic structures containing heterocycles. In particular novel tricyclic structures are investigated as potential drugs.
Ambra Guarnaccio +4 more
doaj +1 more source
Nickel Photocatalytic Access to β‐Arylated β‐Amino Acids
Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.Converting naturally abundant amino acids to non‐canonical derivatives in one step under mild conditions allows for improved pharmaceutical properties. Now, this is achieved for β‐arylated β‐amino acids, which are available in good yields directly from aspartic acid, and have the potential to become platform chemicals for drug discovery.
Tim S. Stamp +3 more
wiley +1 more source
Solid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease
, 2016 The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 protease are known to act as weak inhibitors of the enzyme and have been used
Nathalie Goudreau (1957837) +7 more
core +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer +6 more
wiley +1 more source
Molecules, 2016 A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites.
Ziniu Zhou +2 more
doaj +1 more source
Design and Synthesis of Statine-Based Cell-Permeable Peptidomimetic Inhibitors of Human β-Secretase
, 2016 We describe the development of statine-based peptidomimetic inhibitors of human β-secretase (BACE). The conversion of the peptide inhibitor 1 into cell-permeable peptidomimetic inhibitors of BACE was achieved through an iterative strategy of conceptually
Roy K. Hom (431264) +13 more
core +2 more sources
Solid-Phase Synthesis and Circular Dichroism Study of β-ABpeptoids
Molecules, 2019 The development of peptidomimetic foldamers that can form well-defined folded structures is highly desirable yet challenging. We previously reported on α-ABpeptoids, oligomers of N-alkylated β2-homoalanines and found that due to the presence ...
Ganesh A. Sable +2 more
doaj +1 more source