Results 101 to 110 of about 17,763 (235)
Bactericidal Peptidomimetic Polyurethanes with Remarkable Selectivity against Escherichia coli.
ACS Biomaterials Science & Engineering, 2017 The increasing incidence of drug-resistant strains of bacteria necessitates the development of new classes of antimicrobials. Host defense peptides, also known as antimicrobial peptides, are promising in this regard but have several drawbacks. Herein, we
Steven Mankoci +4 more
semanticscholar +1 more source
In Silico Structure‐Guided Design of Peptide Candidates Targeting γ‐Secretase Subunit Assembly
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 8, Page 1518-1528, August 2026.ABSTRACT The γ‐secretase complex is a membrane‐embedded protease essential for intramembrane cleavage of substrates such as Notch receptors and the amyloid precursor protein (APP), processes central to cancer progression and Alzheimer's disease (AD) pathology.
Selcen Arı Yuka +2 more
wiley +1 more source
Antimicrobial Cyclic Peptidomimetics
Macromolecular Rapid CommunicationsABSTRACTAntimicrobial resistance is a critical global healthcare issue that urgently needs the development of new antimicrobial agents. Herein, we developed new and discrete cationic amphipathic cyclic peptidomimetics as potential antimicrobial agents to combat multidrug‐resistant bacteria.
Hao Luo, Edgar H. H. Wong
openaire +2 more sources
British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh +19 more
wiley +1 more source
Heterocycles in Peptidomimetics and Pseudopeptides: Design and Synthesis
Pharmaceuticals, 2012 This minireview provides a brief outline of the peculiar aspects of the preparation of peptidomimetic and pseudopeptidic structures containing heterocycles. In particular novel tricyclic structures are investigated as potential drugs.
Ambra Guarnaccio +4 more
doaj +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
Chemistry, 2017 This work reports the synthesis of three multimeric RGD peptidomimetic‐paclitaxel conjugates featuring a number of αVβ3 integrin ligands ranging from 2 to 4. These constructs were assembled by conjugation of the integrin αVβ3 ligand cyclo[DKP‐RGD]‐CH2NH2
André Raposo Moreira Dias +7 more
semanticscholar +1 more source
Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview
Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati +4 more
wiley +1 more source
Editorial: Expansion of the Genetic Code: Unnatural Amino Acids and their Applications
Frontiers in Chemistry, 2022 Subhendu Sekhar Bag +2 more
doaj +1 more source
Molecules, 2016 A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites.
Ziniu Zhou +2 more
doaj +1 more source