Results 101 to 110 of about 14,095 (224)
GelsSupramolecular gels were developed by taking advantage of an assembly of small dipeptides containing pyrrolo-pyrazole scaffolds. The dipeptides were prepared through a robust and ecofriendly synthetic approach from the commercially available starting ...
Enrica Chiesa +6 more
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Peptidomimetic compounds and antibody-drug conjugates thereof
, 2014 This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of ...
Gunzner-Toste, J +9 more
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Stereodivergent Synthesis of 5-Aminopipecolic Acids and Application in the Preparation of a Cyclic RGD Peptidomimetic as a nanomolar αVβ3 Integrin Ligand [PDF]
, 2018 A stereodivergent strategy was devised to obtain enantiopure cis and trans 5-aminopipecolic acids (5-APAs) in suitably protected forms to be employed in peptide synthesis as conformationally constrained α- and δ-amino acids.
Ernesto G. Occhiato +24 more
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Synthesis of a [1,4]dioxane-2,5-dione based-peptidomimetic scaffold [PDF]
, 2006 Copyright © ARKAT USA, Inc The document attached has been archived with permission from the publisher.(2S,3S)-3-[N-Cbz-L-Leucinyl]amino-2-hydroxy-4-phenylbutanoic acid 5 dimerised on treatment with EDCI and HOBT to give the symmetrical [1,4]dioxane-2,5 ...
Harvey, A., Abell, A.
core
Antimicrobial Cyclic Peptidomimetics
Macromolecular Rapid CommunicationsABSTRACT Antimicrobial resistance is a critical global healthcare issue that urgently needs the development of new antimicrobial agents. Herein, we developed new and discrete cationic amphipathic cyclic peptidomimetics as potential antimicrobial agents to combat multidrug‐resistant bacteria. These cyclic oligomers
Hao Luo, Edgar H. H. Wong
openaire +3 more sources
Representative conformations after clustering.
, 2012 For each peptidomimetic, 5 conformations in complex with the SH2 domain (in gray) of STAT3 are shown. The 5 conformations are the representatives of the 5 clusters obtained after k-means clustering of the 1000 conformations that were derived from 10 ns ...
Lydia E. Kavraki (111882) +2 more
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, 2016 We have developed a novel protecting-group-free strategy for the synthesis of peptidomimetic conjugates. The high degrees of stereocontrol and chemoselectivity achieved in this chemistry hinge upon unusual preferences of the amphoteric amino aldehydes ...
Andrei K. Yudin (1470634) +1 more
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Short Cationic Peptidomimetic Antimicrobials
Antibiotics, 2019 The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to
Rajesh Kuppusamy +3 more
doaj +1 more source
, 2002 2,3-Diazabicyclo[2.2.1]heptane 1 is used for the first time as a peptidomimetic scaffold in the synthesis of a conformationally constrained analogue 6 of azaproline (or azapipecolic acid) containing ...
Kunwar, Ajit C. +3 more
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Editorial: Expansion of the Genetic Code: Unnatural Amino Acids and their Applications
Frontiers in Chemistry, 2022 Subhendu Sekhar Bag +2 more
doaj +1 more source